Protein Alignment FBXW9 and CG6724

DIOPT Version :10

• Sequence 1: NP_115677.2
• Gene: FBXW9 / 84261
• HGNCID: 28136
• Length: 458
• Species: Homo sapiens
• Sequence 2: NP_609452.1
• Gene: CG6724 / 34488
• FlyBaseID: FBgn0032298
• Length: 420
• Species: Drosophila melanogaster
• Alignment Length: 385
• Identity: 82/385 - (21%)
• Similarity: 146/385 - (37%)
• Gaps: 129/385 - (33%)

Human    71 VSAVSEPGLLSLPPELLLEICSYLDARLVL------HVLSRVCHALRDLVSDHVTWRLRALRRVR 129
            ||||...|      :.:|..|  .|..|.|      |:|:         :|.|.
  Fly   109 VSAVKARG------KWILSGC--YDNTLNLWTNKGKHILT---------ISGHT----------- 145

Human   130 APYPVVEEKNFDWPAACIALEQHLSR--------------WAEDGRWVEYFCLAEGHVASVDSVL 180
            ||...|     ||    |:|::...|              |......||...:.:||...||||.
  Fly   146 APIKAV-----DW----ISLDEETGRFVSTSQDQTAMLWQWNVGSNSVECVSVCKGHERGVDSVS 201

Human   181 LLQGGSLCLSGSRDRNVNLWD-------------LRQLGTESNQVLIKTLGTKRNSTHEGWVWSL 232
            :...|....:||.|..:.:|.             :::.|..:.::.::  |.:.:.:...|:.:.
  Fly   202 VSPDGLRFATGSWDTMLKVWSAELDDAVEGSSKRMKESGVRTPKITLQ--GHRESVSAVQWMDAT 264

Human   233 AAQDHRVCSGSWDSTVKLWDMAADGQQFGEIKASSAVLCLSY--LPDILVTGTYDKKVTIYDPRA 295
            .     :.:||||.|:|:||::.:|.: .||..:.::...||  |..:::|.:.||.:.:||||.
  Fly   265 T-----LLTGSWDHTLKVWDLSLEGIK-TEISTNKSIFDASYSKLNRLILTASADKNLRLYDPRT 323

Human   296 GP-ALLKHQQL-HSRPVLTLL---ADDRHIISGSEDHTLVVVDRRANSVLQRLQLDSYLLCMSYQ 355
            .. :::::..| |:..|.|::   .::...:||:.|:...:.|                 |.|.:
  Fly   324 NQGSVVRNTYLGHNAWVQTVMWSTTEEFLFVSGAYDNQNKLWD-----------------CRSPK 371

Human   356 EPQLWAGDNQGLLHVFANRNGCFQLIRSFDVGHSFPITGIQYSVGALYTTS--TDKTIRV 413
            .|                   .:.|:     ||...:..|.:| ...|..|  .|.|:||
  Fly   372 AP-------------------LYDLL-----GHGEKVLDIDWS-NPKYIVSGGVDNTVRV 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FBXW9	NP_115677.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..64
		F-box_SF	<89..120	CDD:459239	8/36 (22%)
		WD40	<170..457	CDD:441893	57/266 (21%)
		WD 1. /evidence=ECO:0000255	171..210		12/51 (24%)
		WD40 repeat	177..222	CDD:293791	10/57 (18%)
		WD 2. /evidence=ECO:0000255	220..261		10/40 (25%)
		WD40 repeat	227..262	CDD:293791	10/34 (29%)
		WD 3. /evidence=ECO:0000255	264..301		10/39 (26%)
		WD40 repeat	270..301	CDD:293791	10/33 (30%)
		WD40 repeat	305..344	CDD:293791	8/42 (19%)
		WD 4. /evidence=ECO:0000255	305..342		8/40 (20%)
		WD 5. /evidence=ECO:0000255	344..381		3/36 (8%)
		WD40 repeat	350..385	CDD:293791	4/34 (12%)
		WD 6. /evidence=ECO:0000255	387..424		10/29 (34%)
		WD40 repeat	392..413	CDD:293791	6/22 (27%)
		WD 7. /evidence=ECO:0000255	427..458
CG6724	NP_609452.1	NLE	10..75	CDD:462380
		WD40	<105..406	CDD:441893	80/383 (21%)
		WD40 repeat	198..250	CDD:293791	9/53 (17%)
		WD40 repeat	255..288	CDD:293791	10/38 (26%)
		WD40 repeat	296..333	CDD:293791	10/36 (28%)
		WD40 repeat	340..378	CDD:293791	9/73 (12%)