Protein Alignment SGIP1 and SYP1

DIOPT Version :10

• Sequence 1: XP_016857994.1
• Gene: SGIP1 / 84251
• HGNCID: 25412
• Length: 850
• Species: Homo sapiens
• Sequence 2: NP_009959.2
• Gene: SYP1 / 850396
• SGDID: S000000626
• Length: 870
• Species: Saccharomyces cerevisiae
• Alignment Length: 882
• Identity: 185/882 - (20%)
• Similarity: 297/882 - (33%)
• Gaps: 247/882 - (28%)

Human    17 KKEKDTDSTGSPDRDGIQPSPHEPPYNSKAECAREGGKKVSKKSNGAPNGF--YAEIDWERYNSP 79
            ::.||..|..|.:...|:   |....|..:....|..::..::|   |..|  :..||:.|.::.
Yeast   141 RESKDLHSKLSKNAASIE---HYSKNNENSSHLEEARRQWDQQS---PYLFELFETIDYNRLDTL 199

Human    80 -------ELDEEGYSIRPE---EPGSTKGKHFYSSSESEEEEESHKKFNIKIKPLQSKDILKN-- 132
                   :.....|.:...   |...||...|...||.:...:...::|.::.. .||:::.|
Yeast   200 KNCMLRFQTSFSDYLLNTTKECETVMTKFLAFEPQSEIDRFAKDASQYNFQLSS-SSKEVVPNNA 263

Human   133 --AATVDELKASIGNIALSPSPVRKSPRRSP-----GAIKRNLSSEEVARPRR---------STP 181
              |:.......|:.|.|.:....:|||::..     |.|...|:|...:....         ||.
Yeast   264 SPASATGARPVSVSNGAANTEREKKSPQKDKRKSAFGNIGHRLASASSSLTHNDLMNNEFSDSTN 328

Human   182 TPELISKKPPDDTTALAPLFGPPLESAFDEQKTEVLLDQPEIWGSGQPINPSMESPKLTRPFPTG 246
            ...|.|||   .:..|....|    |.|...||:....|..  .|...|..|:          |.
Yeast   329 NSSLKSKK---SSHTLRSKVG----SIFGRNKTKNKRQQQS--SSNSHIQASI----------TE 374

Human   247 TPPPLPPKNVPATPPRTGSPLTIGPGNDQSATEVKIEKLPSINDLDSIFGPVLSPKSVAVNAEEK 311
            ||                         :.|:|.|      |.....||:.....| :.:.:....
Yeast   375 TP-------------------------NNSSTRV------SSTATSSIYQKQRRP-TYSSSKSNN 407

Human   312 WV--HFSDTSPEHVTPELTPREKVVSPPATPDNPADSPAPGPLGPPGPTGPPG--PPGPPRNVLS 372
            |.  ..|||.|  :.|..||  |.|..|.|.|.           ||..|..|.  ||
Yeast   408 WTPGEASDTPP--LPPHATP--KNVDAPVTADT-----------PPAQTFTPSEVPP-------- 449

Human   373 PLNLEEVQKKVAEQTFIKDDYLETISSPKDFGLGQRATPPPPPPPTYRTVVSSPGPGSGPGPGTT 437
                                                :||....|||.:...||..|.:.|
Yeast   450 ------------------------------------STPQQSSPPTAKEPDSSNLPKTVP----- 473

Human   438 SGASSPARPATPLVPCRSTTPPPPPPRPP--SRPKLPPGKPGVGDVSRPFSPPIHSSSP--PPIA 498
               .|.::|  ||.|...|.|.|..|..|  |.|.........|.|.   |.|:|..:|  ||
Yeast   474 ---ISISQP--PLQPQSKTKPLPVEPASPSISLPTATVDNQPSGQVD---SRPLHIRAPALPP-- 528

Human   499 PLARAESTSSISSTNSLSAATTPTVVSEDDVFYDKLPSFERRCETPAENEQPSLVWFDRGKFYLT 563
              :|.::                .:.:.|...||.||:..... ||..:...|:.. :|....|:
Yeast   529 --SRKQN----------------FIHNRDSQLYDSLPNHGSGA-TPTSSSLSSIPQ-ERPVSTLS 573

Human   564 FE--GSSRGPSPLTMGAQDTL----------------PVAAAFTETVNAYFKGADPSKCIVKITG 610
            .:  |..|..:|...|:..:|                .:.|:..|.:||.||  |......::.|
Yeast   574 SQITGELRELNPQATGSSTSLVGQSLFQHSSLDTSQFGLNASIAEVLNASFK--DGMLQNSQLIG 636

Human   611 EMVLSFPAGITRHFANNPSPAALTFRVINFSRLEHVLPNPQLLCCDNTQNDANTKEFWVNMPNLM 675
            |:.|::   :.....|:|.|..:..|:.|.::.|.|:.|...:      .....:||.|| |:.:
Yeast   637 EIALNY---LPNSVMNSPLPIGINLRINNGAKFEKVILNQAFI------ERVAPEEFKVN-PSFI 691

Human   676 THLKKVSEQKPQATYYNVDMLKYQVSAQGIQSTPLNLAVNWRCEPSSTDLRIDYKYN---TDAMT 737
            ..             ..:..:||.:..   ...|:.:...||.|.....:.:..|.:   .|.::
Yeast   692 DS-------------RTLGAIKYSIKE---PIAPIVIHPVWRFESHQASVVLTVKMSPSLPDEIS 740

Human   738 TAVALNNVQFLVPIDGGVTKLQAVLPPAVWNAEQQRILWKIPDISQKSENGGVGSLLARFQLSEG 802
            ..|..:.|.| |.|||.........|...::.|::||.|:..:....:.||....|:||| :::|
Yeast   741 QIVIEDLVVF-VNIDGANATSALSKPQGSFSKEKKRITWRFKEPVVLTRNGEGQRLIARF-ITDG 803

Human   803 PSKPSP--LVVQFT-SEGSTLSGCDIELVGAGYRFSL 836
            .:..|.  ::.:|| ||...::   :...|||...:|
Yeast   804 LAHESAKGVITKFTISETDNVA---LPHSGAGSGITL 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SGIP1	XP_016857994.1	SGIP1_MHD	583..849	CDD:271172	59/260 (23%)
SYP1	NP_009959.2	F-BAR_Syp1p_like	16..250	CDD:153334	22/114 (19%)
		PHA03307	251..>530	CDD:223039	88/406 (22%)
		Atrophin-1	<393..>580	CDD:460830	61/281 (22%)
		muHD	610..867	CDD:463046	59/261 (23%)