DRSC/TRiP Functional Genomics Resources

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Protein Alignment PSD2 and SEC7

DIOPT Version :10

Sequence 1:NP_115665.1 Gene:PSD2 / 84249 HGNCID:19092 Length:771 Species:Homo sapiens
Sequence 2:NP_010454.3 Gene:SEC7 / 851748 SGDID:S000002577 Length:2009 Species:Saccharomyces cerevisiae


Alignment Length:537 Identity:116/537 - (21%)
Similarity:208/537 - (38%) Gaps:107/537 - (19%)


- Green bases have known domain annotations that are detailed below.


Human   220 SPLRRSISSSRSENVLSRLSLMAMPNGFHEDGPQGPGGDEDDDEEDTDKLLNSASDPSLKDGLSD 284
            |..|:...||.|.:|  |.|:|...:.|...       .||::..........|.||:..:.|..
Yeast   771 SSARQESRSSLSNDV--RSSIMTSNDDFKPT-------YEDEESRSLSSQNIDADDPTQFENLKL 826

Human   285 SDSELSSSEGL---EPGSADP--LANGCQGVSEAAHRLARRLYHLEGFQRCDVARQLGKNNEFSR 344
            ..:.||....:   :|..|.|  :..|.. ..::...:|:.|...||.....|...||:.::.:.
Yeast   827 RKTALSECIAIFNNKPKKAIPVLIKKGFL-KDDSPISIAKWLLETEGLDMAAVGDYLGEGDDKNI 890

Human   345 LVAGEYLSFFDFSGLTLDGALRTFLKAFPLMGETQERERVLTHFSRRYCQCNPDDSTSEDGIHTL 409
            .:...::..|||:|:::..|||:||::|.|.||.|:.:|.:..|:.|:...||...:..|..:.|
Yeast   891 AIMHAFVDEFDFTGMSIVDALRSFLQSFRLPGEGQKIDRFMLKFAERFVDQNPGVFSKADTAYVL 955

Human   410 TCALMLLNTDLHGHNIGKKMSCQQFIANLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDED--- 471
            :.:|::||||||...|..|||.|:|:.|.:.:::|:|..:|.|:.|:|.|.|.:::...::.   
Yeast   956 SYSLIMLNTDLHSSQIKNKMSLQEFLENNEGIDNGRDLPRDFLEGLFNEIANNEIKLISEQHQAM 1020

Human   472 ---------------------ELRKSLSELVDDKFGTGTKKVTRILDGGNPFLDVPQALSATTYK 515
                                 :|.:.....|..:..:.|:.|.:.|:......||..|.|...:.
Yeast  1021 LSGDTNLVQQQQSAFNFFNSRDLTREAYNQVSKEISSKTELVFKNLNKNKGGPDVYYAASHVEHV 1085

Human   516 HGVLTRKTHADMDGKRTPRGRRGWKKFYAVLKGTILYLQKDEYRPDKALSEGDLKNAIRVHHALA 580
            ..:....                |..|.|.|  |..:...|:........|| ||.:|::  |..
Yeast  1086 KSIFETL----------------WMSFLAAL--TPPFKDYDDIDTTNKCLEG-LKISIKI--AST 1129

Human   581 TRASD-----------YSKKSNV--LKLKTADWRVFLFQAPSKEE------------MLSWILRI 620
            .|.:|           :....|:  :|:|..:..|.|.:....|.            ::|.:.|:
Yeast  1130 FRINDARTSFVGALVQFCNLQNLEEIKVKNVNAMVILLEVALSEGNYLEGSWKDILLVVSQMERL 1194

Human   621 NLVAAIFSAPAFPAAVSSMKKFCRPLLPSCTTRLCQEEQLRSHENKL------RQLTAELAEHRC 679
            .|::........|....:  :...|.:        ..|..||:....      :....|||:.:.
Yeast  1195 QLISKGIDRDTVPDVAQA--RVANPRV--------SYESSRSNNTSFFDVWGKKATPTELAQEKH 1249

Human   680 H------PVERGIKSKE 690
            |      .:.:.|.|.|
Yeast  1250 HNQTLSPEISKFISSSE 1266

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PSD2NP_115665.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..67
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 107..136
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 207..230 3/9 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 244..307 12/67 (18%)
Sec7 297..464 CDD:238100 54/168 (32%)
PH_EFA6 510..633 CDD:270107 24/147 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 739..771
SEC7NP_010454.3 PLN03076 272..1935 CDD:215560 116/537 (22%)
Blue background indicates that the domain is not in the aligned region.

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