Protein Alignment ATP13A4 and Atpalpha

DIOPT Version :10

• Sequence 1: XP_047305019.1
• Gene: ATP13A4 / 84239
• HGNCID: 25422
• Length: 1239
• Species: Homo sapiens
• Sequence 2: NP_732572.1
• Gene: Atpalpha / 48971
• FlyBaseID: FBgn0002921
• Length: 1041
• Species: Drosophila melanogaster
• Alignment Length: 992
• Identity: 215/992 - (21%)
• Similarity: 379/992 - (38%)
• Gaps: 258/992 - (26%)

Human   147 TPDHPLMTDEEYIINRAIRKPDLKVRCIKVQKIRYVWNYLEGQFQKIGSLEDWLSSAKIHQKFGS 211
            |.|.....|.:|   ::.||...||.  |.:.:..:...|:..|.|| |.|:.....:.|.:.|.
  Fly    23 TDDDNRTADGQY---KSRRKMPAKVN--KKENLDDLKQELDIDFHKI-SPEELYQRFQTHPENGL 81

Human   212 GLTREEQEIRRLICGPNTI-DVEVTPIWKLLIKEVLNPFYIFQLFSVCLWFSEDYKEYAFAI--- 272
            ...:.::.:.|  .|||.: ..:.||.|....|.      :|..|::.||........|::|
  Fly    82 SHAKAKENLER--DGPNALTPPKQTPEWVKFCKN------LFGGFAMLLWIGAILCFVAYSIQAS 138

Human   273 -------------IIMSIISISLTVYDLREQSVKLHHLVESHNSI-----TVSVCGRKAGVQELE 319
                         |::|.:.|...::...::| |...::||..::     ||...|.|.   .|.
  Fly   139 TSEEPADDNLYLGIVLSAVVIVTGIFSYYQES-KSSKIMESFKNMVPQFATVIREGEKL---TLR 199

Human   320 SRVLVPGDLL-ILTGNKVLMPCDAVLIEG-SCVVDEGMLTGESIPVTKTPLPKMDSSVPWKTQSE 382
            :..||.||:: :..|:::  |.|..:||. :..||...|||||.|.::.  .:.....|.:|
  Fly   200 AEDLVLGDVVEVKFGDRI--PADIRIIEARNFKVDNSSLTGESEPQSRG--AEFTHENPLET--- 257

Human   383 ADYKRHVLFCGTEVIQAKAACSGTVRAVVLQTGFNTAKGDLVRSILYPKPVNFQLYRDAIRFLLC 447
                :::.|..|..::      ||.:.||:..|.:|..|.:.............:.::...|:..
  Fly   258 ----KNLAFFSTNAVE------GTAKGVVISCGDHTVMGRIAGLASGLDTGETPIAKEIHHFIHL 312

Human   448 LVGTAT-IGMIYTLCVYVLSGEPPEEVVRKALDVITIAVPPALPAALTTGIIYAQRRLKKRGIFC 511
            :.|.|. :|:.:.:..::| |....:.|...:.:|...||..|.|.:|..:....:|:..:....
  Fly   313 ITGVAVFLGVTFFVIAFIL-GYHWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLV 376

Human   512 ISPQRINVCGQLNLVCFDKTGTLTRDGL---DLW--------------GVVSCDRN--GFQEVH- 556
            .:.:.:...|..:.:|.|||||||::.:   .:|              ..|..||.  ||:.:.
  Fly   377 KNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIIEADTTEDQSGVQYDRTSPGFKALSR 441

Human   557 --------SFASGQ-ALPWGPLCAAMASCHSLILLDGTIQGDPLDLKMFEATTWEMAFSGDDFHI 612
                    .|..|| .:|               :|...:.||..:..:.:.  .|:|. ||..:|
  Fly   442 IATLCNRAEFKGGQDGVP---------------ILKKEVSGDASEAALLKC--MELAL-GDVMNI 488

Human   613 KGVPAHAMVVKPCRTASQVPVEGIAILHQFPFSSALQRMTVI--VQEMGGDR-LAFMKGAPERVA 674
            :         |..:..::|           ||:|..:....|  .::....| |..|||||||:.
  Fly   489 R---------KRNKKIAEV-----------PFNSTNKYQVSIHETEDTNDPRYLLVMKGAPERIL 533

Human   675 SFCQ-----------PETVPTSFVSELQIYTTQGFRVIALAYKKLENDHHATTLTRETVE----- 723
            ..|.           .|.:..:|.:........|.||:......|.:|.:.......|.:
  Fly   534 ERCSTIFINGKEKVLDEEMKEAFNNAYMELGGLGERVLGFCDFMLPSDKYPNGFKFNTDDINFPI 598

Human   724 SDLIFLGLLILENRLKEETKPVLEELISARIRTVMITGDNLQTAITVARKSGMVSESQKVILIEA 788
            .:|.|:||:.:.:..:......:.:..||.|:.:|:|||:..||..:|:..|::|        |.
  Fly   599 DNLRFVGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKSVGIIS--------EG 655

Human   789 NETTGSSSASISWTLV-----EEKKHIMYGNQDNYINIRDEVSDKGREGSYHFALTGKSFHVISQ 848
            |||....:..::..:.     |.|..:::|.:     :||..||:
  Fly   656 NETVEDIAQRLNIPVSEVNPREAKAAVVHGAE-----LRDVSSDQ-------------------- 695

Human   849 HFSSLLPKILINGT--IFARMSPGQKSSLVEEFQKLDYFVGMCGDGANDCGALKMAHVGISL--- 908
                 |.:||...|  :|||.||.||..:||..|::...|.:.|||.||..|||.|.:|:::
  Fly   696 -----LDEILRYHTEIVFARTSPQQKLIIVEGCQRMGAIVAVTGDGVNDSPALKKADIGVAMGIA 755

Human   909 ----SEQEASVASPFTSKTPNIECVPHLIKEGRAALVTSFCMFKYMALYSMIQYVGVLLLYWETN 969
                |:|.|.:.               |:.:..|::||
  Fly   756 GSDVSKQAADMI---------------LLDDNFASIVT--------------------------- 778

Human   970 SLSNYQFLFQDLAITTLIGVTMNLNGAYPKLVPFRPAGRLISPPLLLSVIFNIL----------- 1023
            .:...:.:|.:|..:....:|.|:    |::.||. |..|...||.|..: .||
  Fly   779 GVEEGRLIFDNLKKSIAYTLTSNI----PEISPFL-AFILCDIPLPLGTV-TILCIDLGTDMVPA 837

Human  1024 LSLAMHIAGFILVQRQP 1040
            :|||...|...:::|.|
  Fly   838 ISLAYEHAEADIMKRPP 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP13A4	XP_047305019.1	P5-ATPase	59..184	CDD:463565	9/36 (25%)
		P-type_ATPase_cation	216..1058	CDD:319842	198/923 (21%)
Atpalpha	NP_732572.1	ATPase-IIC_X-K	45..1041	CDD:273445	207/967 (21%)