Protein Alignment ATP13A4 and SPoCk

DIOPT Version :10

• Sequence 1: XP_047305019.1
• Gene: ATP13A4 / 84239
• HGNCID: 25422
• Length: 1239
• Species: Homo sapiens
• Sequence 2: NP_001262220.1
• Gene: SPoCk / 40495
• FlyBaseID: FBgn0052451
• Length: 1062
• Species: Drosophila melanogaster
• Alignment Length: 1061
• Identity: 249/1061 - (23%)
• Similarity: 434/1061 - (40%)
• Gaps: 205/1061 - (19%)

Human   211 SGLTREEQEIRRLICGPN-TIDVEVTPIWKLLIKEVLNPFYIFQLFSVCLWFSEDYKEYAFAIII 274
            :||...|.:.|..|.|.| .:.|...|.||..|::..||..:..|.|..:  |...|::..|:.|
  Fly   129 TGLKWTEAKYRAKIIGHNELLLVAEDPTWKKYIEQFRNPLILLLLGSALV--SVIMKQFDDAVSI 191

Human   275 MSIISISLTVYDLRE-QSVK----LHHLV--ESHNSITVSVCGRKAGVQELESRVLVPGDLLIL- 331
            ...|.|.:||..::| :|.|    |..||  |.|       |.|:..:....:|.|||||::.|
  Fly   192 TIAILIVVTVAFIQEYRSEKSLEELKKLVPPECH-------CLREGRLDTFLARELVPGDIVHLN 249

Human   332 TGNKVLMPCDAVLIEG-SCVVDEGMLTGESIPVTKTPLPKMDSSVPWKTQSEADYK--RHVLFCG 393
            .|::|  |.|..|.|. ...:||...|||:.|..|.      :.|.....:..|:.  :::.|.|
  Fly   250 VGDRV--PADVRLFEAVDLSIDESSFTGETEPARKI------TDVLLNNTNVKDHSNMKNIAFMG 306

Human   394 TEVIQAKAACSGTVRAVVLQTGFNTAKGDLVRSIL---YPKPVNFQLYRDAIRFLLCLVGTATIG 455
            |.|     .| |..:.:|:.||..:..|::.:.:.   .|| ...|...|.:...|.......||
  Fly   307 TLV-----RC-GNGKGIVVSTGERSEFGEVFKMMQAEEAPK-TPLQKSMDILGAQLSFYSFLIIG 364

Human   456 MIYTLCVYVLSGEPPEEVVRKALDVITIAVPPALPAALTTGIIYAQRRLKKRGIFCISPQRINVC 520
            :|  :.:..|.|:|..|:...::.:...|:|..||..:|..:.....|:.||.........:...
  Fly   365 VI--MLLGWLQGKPLSEMFNISVSLAVAAIPEGLPIVVTVTLALGVMRMAKRNSIVKKLPTVETL 427

Human   521 GQLNLVCFDKTGTLTRDGLDLWGVVSCD----------RNGFQEVH-------SFASGQALPWGP 568
            |.:|::|.|||||||::.:....:::.|          .|...|:|       ..|.....   .
  Fly   428 GCVNVICSDKTGTLTKNEMTATIIITSDGYMADVTGAGYNDQGEIHIRHCNNVEMAKTNIT---N 489

Human   569 LCAAMASCHSLILLDGTIQGDPLDLKMFEATTWEMAFSGDDFHIKGVPAHAMVVKPCRTASQVPV 633
            |....|.|::..:.:||:.|.|.:                         .|:|....:.......
  Fly   490 LLEIGAVCNNAYIQNGTLLGQPTE-------------------------GALVAVAMKNGMYATA 529

Human   634 EGIAILHQFPFSSALQRMTV-IVQEMGGDR--LAFMKGAPERVASFCQ-----PETVP------T 684
            |....:.::||||..:.|.| .:.:...::  :.|.|||.|.:...|.     .:|||      .
  Fly   530 ENYVRIQEYPFSSEQKMMAVKCIHKYNNNKEEIFFAKGALETLLPQCTKYQFGTQTVPLTKQNEA 594

Human   685 SFVSELQIYTTQGFRVIALAYKKLENDHHATTLTRETVESDLIFLGLLILENRLKEETKPVLEEL 749
            .|::|......:|.||:|||              :.....|||:.||:.:.:..:...:..:|.|
  Fly   595 EFLAEAYEIGRKGLRVLALA--------------KGRSMQDLIYCGLVGITDPPRPLVRESIEML 645

Human   750 ISARIRTVMITGDNLQTAITV--ARKSGMVSESQKVILIEANETTG-----SSSASISWTLVEEK 807
            :.:.:|..|:|||..:||:.:  :|:...|...    .|.|..|.|     |:||..|...:|..
  Fly   646 MQSGVRVKMVTGDAQETALAIDPSRRLQAVPTH----AIPAWPTAGGVPLCSASACCSTNCLENA 706

Human   808 KHIMY----GNQD------NYINIRDEVSDKGREGSYHFALTGKSFHVISQHFSSLLPKILINGT 862
            ...:|    ..|.      |.|.| |.:        :|..|:|:....:::|   .|.|:..|.:
  Fly   707 MKEIYLTALAQQGLPLVTANLIGI-DTI--------HHQTLSGQEMDQMNEH---QLDKVANNVS 759

Human   863 IFARMSPGQKSSLVEEFQKLDYFVGMCGDGANDCGALKMAHVGISLSEQEASV---ASPFTSKTP 924
            :|.|:||..|..:|:..|:....|||.|||.||..|||.|.:||::.:....|   |:.......
  Fly   760 VFYRVSPRHKLEIVKSLQRSGNIVGMTGDGVNDGVALKKADIGIAMGKNGTDVCKEAADMILVND 824

Human   925 NIECVPHLIKEGRAAL--VTSFCMFKYMALYSMIQYVGVLLLYWETNSLSNYQFLFQDLAITTLI 987
            :...:...|:||:...  :.:|..|:.....:.:..:.:..|....|.|:..|.|:.::.:....
  Fly   825 DFHTIIAAIEEGKGIFYNIRNFVRFQLSTSIAALALIALATLMDIANPLNAMQILWINIIMDGPP 889

Human   988 GVTMNLNGAYPKLVPFRPAGRLISPPLLL-SVIFNILLSLAMHIAGFILV-QRQPWYSVEIHSAC 1050
            ..::.:......::..:|  |.:..|::. ||:.|:|||.::.:.|.:.| ||:
  Fly   890 AQSLGVEPVDHDVLKQKP--RNVKQPMITKSVVVNVLLSASIIVLGTLWVFQRE----------- 941

Human  1051 TVQNESISELTMSPTAPEKMESNSTFTSFENTTVWF--LGTINCIT-VALVFSKGKPFRQPTYTN 1112
                  :::.|:..|   |.::..|||.|    |:|  ...::|.: ...||:.|      ..||
  Fly   942 ------MADGTLGKT---KRDTTMTFTCF----VFFDMFNALSCRSQTKSVFTIG------LTTN 987

Human  1113 YIFVLVLIIQ-LGVCLFILFADIPELYRRLDLLCTPVLWRASIVIMLSLNFIVSLVAEEAVIENR 1176
            .:|:|.:... :|..|.:.|..:..:::...|  ||          ..:.|:|||.:...|:...
  Fly   988 RMFLLAVAFSIIGQMLVVYFPPLQMVFQTEAL--TP----------YDIFFLVSLTSSVLVVSEI 1040

Human  1177 ALWM---MIKRCFGYQSKSQY 1194
            ..|.   |.::.:..:|:..:
  Fly  1041 KKWFERTMERKMYSTRSELDF 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP13A4	XP_047305019.1	P5-ATPase	59..184	CDD:463565
		P-type_ATPase_cation	216..1058	CDD:319842	216/911 (24%)
SPoCk	NP_001262220.1	P-type_ATPase_SPCA	139..1042	CDD:319779	243/1030 (24%)