Protein Alignment ATP13A4 and CG6230

DIOPT Version :10

• Sequence 1: XP_047305019.1
• Gene: ATP13A4 / 84239
• HGNCID: 25422
• Length: 1239
• Species: Homo sapiens
• Sequence 2: NP_609490.1
• Gene: CG6230 / 34546
• FlyBaseID: FBgn0027582
• Length: 1225
• Species: Drosophila melanogaster
• Alignment Length: 1248
• Identity: 335/1248 - (26%)
• Similarity: 548/1248 - (43%)
• Gaps: 277/1248 - (22%)

Human    88 ILPLVFYWRPAWHVWAHCVPCSLQEADT----VLL----RTTDEFQIYSWKKVIWI------YLS 138
            :||.|..:..|:::|.:..  ..||.||    |:.    .|||  .|.:|..|.:|      :|.
  Fly    58 VLPFVPLYLSAFYLWINVT--GGQENDTTNNDVITADNQTTTD--NITTWNDVGFIGVLAIAFLH 118

Human   139 ALNSAFGLTPDHPLMTDEEYIINRAIRKPD------------------LKVRCIKV--------- 176
            .|...|.....|.|    .::..|.::.|.                  :.:|..|:
  Fly   119 ILTLLFCYWSVHVL----AFLTCRRVKLPGANVLAKVVPTPNNGNSKIVPIRSSKLEDGSTQYYF 179

Human   177 --QKIRYVWNYLEGQFQKI-----GSLEDWLSSAKIHQKFGSGLTREEQEIRRL--ICGPNTIDV 232
              ||.:||||.....|:.:     |.|..:.||        .||..|| :|:|.  ..|.|.:::
  Fly   180 VFQKTKYVWNEDRKTFRAVEFPVNGLLSTYSSS--------RGLETEE-DIKRATQTYGNNEMEM 235

Human   233 EVTPIWKLLIKEVLNPFYIFQLFSVCLWFSEDYKEYAFAIIIMSIISISLTVYDLREQSVKLHHL 297
            .|....:|.|:....||::||:|||.||..:||..|:...:.| :|:...|:  :::|...:..:
  Fly   236 VVPEFHELFIERATAPFFVFQVFSVGLWCMDDYWYYSLFTLFM-LIAFECTI--VKQQLRNMSEI 297

Human   298 VESHNSITVSVCGRKAGVQELESRVLVPGDLLILT--GNKVLMPCDAVLIEGSCVVDEGMLTGES 360
            .:..|...:....|:...:.|.|..|:||||:.:|  .|..::|||.|::.|||:|||.||||||
  Fly   298 RKMGNKPYLIYAFRQNKWRHLGSDELLPGDLVSITRSQNDNIVPCDLVILRGSCIVDESMLTGES 362

Human   361 IPVTKTPLPKMDSSVPWKTQSEADYKRHVLFCGTEVIQAKAACSGTVRA-------VVLQTGFNT 418
            :|:.|..|..:| ::..:..:|.|.|..|||.||:|:|..|....::||       .|::|||||
  Fly   363 VPLMKESLESLD-NLDVEMDAEGDGKLFVLFGGTKVVQHTAPTKESLRAPDGGCIGYVIRTGFNT 426

Human   419 AKGDLVRSILYPKPVNFQLYRDAIRFLLCLVGTATIGMIYTLCVYVLSGEPPE----EVVRKALD 479
            ::|.|:|:||:......:...:...|:..|:..|.....|   |:|...|.||    ::..:...
  Fly   427 SQGKLLRTILFGANRATENNVETFAFIAFLMVFAVAAASY---VWVKGSEDPERNRYKLFLECTL 488

Human   480 VITIAVPPALPAALTTGIIYAQRRLKKRGIFCISPQRINVCGQLNLVCFDKTGTLTRDGLDLWGV 544
            ::|..:||.||..||..:..:..:|.|..:||..|.||...|::.:.|||||||||.|.|.:.|:
  Fly   489 ILTSIIPPDLPIELTLAVNTSLIQLTKLFVFCTEPFRIPFAGKVQICCFDKTGTLTTDNLMVEGI 553

Human   545 VSCDRNGFQEVHSFASGQALPWGPLCAAMASCHSLILLDGTIQGDPLDLKMFEATTWEMAFSGDD 609
            .....||.......|.|..:      ..:|.||||.|||..:.||||:.....|..|.:.
  Fly   554 AGLAPNGACVPIEKAEGNTV------QVLACCHSLALLDDGLVGDPLEKATLAAVDWTLT----- 607

Human   610 FHIKGVPAHAMVVKPCRTASQVP----VEGIAILHQFPFSSALQRMTVI----------VQEMGG 660
                            :..|.:|    .:.:.|:.::.|||||:||:|:          |:.:|.
  Fly   608 ----------------KMDSVIPKRPQFKPLKIIQRYHFSSALKRMSVLAGHLIPYSNEVKHIGA 656

Human   661 DRLAFMKGAPERVASFCQPETVPTSFVSELQIYTTQGFRVIALAYKKLE--NDHHATTLTRETVE 723
                 :|||||.:....:  .||..:......|..:|.||:||..|.|.  .......:.||.||
  Fly   657 -----VKGAPEVIQKMLR--EVPADYEKVYLEYARRGARVLALGIKDLGTLGAQRVREMKREEVE 714

Human   724 SDLIFLGLLILENRLKEETKPVLEELISARIRTVMITGDNLQTAITVARKSGMVSESQKVILIEA 788
            .||.|.|.||:...:|.::|.|::|||.:..:.||||||:..||..|||:  :....:|:|::..
  Fly   715 CDLTFAGFLIISCPMKPDSKSVIKELIQSSHKVVMITGDSPLTACHVARE--LRFTRKKLIILTP 777

Human   789 NETTGSSSASISWTLVEEKKHIMYGNQDNYINIRDEVSDKGRE------GSYHFALTGKSFHVIS 847
            .|....:  :.||..::       |:|...::.:     .|.:      .::...:||:....:.
  Fly   778 PEEDRKN--NWSWVSID-------GDQSYELDTK-----PGSKKLSHLLATHDLCITGEGLQYLQ 828

Human   848 ----QHFSSLLPKILINGTIFARMSPGQKSSLVEEFQKLDYFVGMCGDGANDCGALKMAHVGISL 908
                |:...|||:|    |:.||.:|.||..::.:.::|.|...|||||.||.||||.|:||:||
  Fly   829 QNQPQYMRQLLPQI----TVCARFAPKQKELVITQLKQLGYCTLMCGDGTNDVGALKHANVGVSL 889

Human   909 ----------SEQE--------------------------------------------------- 912
                      :|:|
  Fly   890 LTSAPVKRKRTEEEQQQAAANAAAIAAQAQANANQQLTTRERALRRRQEHLNQTQARLQNALRDM 954

Human   913 ----------ASVASPFTSKTPNIECVPHLIKEGRAALVTSFCMFKYMALYSMIQYVGVLLLYWE 967
                      ||:|:|||||:.:|.||.|:||:||..|||:..|||.:||.::||.....:||.:
  Fly   955 EEQTMVKLGDASIAAPFTSKSSSIMCVNHIIKQGRCTLVTTLQMFKILALNALIQAYCQSVLYID 1019

Human   968 TNSLSNYQFLFQDLAITT-LIGVTMNLNGAYPKLVPFRPAGRLISPPLLLS--VIFNILLSLAMH 1029
            ....|:.|...|.:.|.. .:.:|        :..|.:...::...|.:.:  .|..||...|:|
  Fly  1020 GIKFSDTQATMQGIFIAACFLFIT--------RAKPLKTLSKVAPLPNIFNFYTISTILSQFAVH 1076

Human  1030 IAGFILVQRQPWYSVEIHSACTVQNESISELTMSPTAPEKMESNSTFTSFENTTVWFLG-TINCI 1093
            ....       :|.....:......|...:|.:...|.||.:.:....|   :||:.:. ::...
  Fly  1077 FGTL-------YYLTSQANILAPPREGKVKLYIDMDAEEKTKYDPNIVS---STVYIICLSLQVA 1131

Human  1094 TVALVFSKGKPFRQPTYTNYIFV--------LVLIIQLGVCLFILFADIPELYRRLDLLCTPVLW 1150
            |:|:.: ||.||.:...:|.:.:        ||:::..|:.        |||....:::..|..:
  Fly  1132 TIAVNY-KGYPFMESLRSNRMLMYAIGASAALVILLSTGLA--------PELTEFFEIIDFPTDF 1187

Human  1151 RASIVIMLSLNFI 1163
            |.:::.:|.|:.:
  Fly  1188 RKTLLGVLVLDIV 1200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP13A4	XP_047305019.1	P5-ATPase	59..184	CDD:463565	30/138 (22%)
		P-type_ATPase_cation	216..1058	CDD:319842	272/956 (28%)
CG6230	NP_609490.1	P-type_ATPase_cation	220..1152	CDD:319843	284/1011 (28%)