Protein Alignment ATP13A4 and anne

DIOPT Version :10

• Sequence 1: XP_047305019.1
• Gene: ATP13A4 / 84239
• HGNCID: 25422
• Length: 1239
• Species: Homo sapiens
• Sequence 2: NP_001096849.1
• Gene: anne / 317815
• FlyBaseID: FBgn0052000
• Length: 1451
• Species: Drosophila melanogaster
• Alignment Length: 1322
• Identity: 465/1322 - (35%)
• Similarity: 700/1322 - (52%)
• Gaps: 223/1322 - (16%)

Human    54 LLNEGEENEMEIFGYRTQGCRKSLCLAGSIFSFGILPLVFYWRPAWHVWAHCVPCSLQEADTVLL 118
            |||..:|::|::.|||....|...|.|....:.|:|.||.:|....:::|.|..|||:||:.||:
  Fly   153 LLNPDQEDQMKVCGYRRSLMRTGFCWACIFLTGGLLRLVLHWWRHLYLYATCSQCSLEEAEQVLV 217

Human   119 RTTDEFQ----IYSWKKVIWIYLSALNSAFGLTPDHPLMTDEEYIINR----------------- 162
              |:::|    :|..|::..:..|.|.:         |:..|:..|.|
  Fly   218 --TEDYQGKHKMYHVKQIQVLTSSNLKT---------LLEKEQQSIERTHIECDHVENVLQLSVH 271

Human   163 ---AIRKPDLKVRCIKVQKIRYVWNYLEGQFQKIGSLEDWLSSAKIHQKFGSGLTREEQEIRRLI 224
               |..|....:|..:.:::.|.||....:||:|..|:..:..:..||:  .||...||..||::
  Fly   272 FTSAQFKKCSSIRIFRCKQLVYAWNNNTNRFQRINGLDLNIPCSYYHQQ--RGLPVHEQISRRIV 334

Human   225 CGPNTIDVEVTPIWKLLIKEVLNPFYIFQLFSVCLWFSEDYKEYAFAIIIMSIISISLTVYDLRE 289
            .|.|.|.|.:.....||..|||||||:||||||.|||:.||..||..|::||:..|:::|...::
  Fly   335 FGDNEITVPLRDFKTLLFLEVLNPFYVFQLFSVILWFTYDYYYYACVILLMSVFGITVSVLQTKK 399

Human   290 QSVKLHHLVESHNSITVSVCGRKAGVQELESRVLVPGDLLILTGNKVLMPCDAVLIEGSCVVDEG 354
            ....|...|  :|:....|...|...:||.:|.:||||::.:..:...:.|||:||.|:|::||.
  Fly   400 NQDVLQKTV--YNTGNAWVVDHKGLSKELPTRAIVPGDIIEIPSSGCTLHCDAILISGNCILDES 462

Human   355 MLTGESIPVTKTPLPKMDSSVPWKTQSEADYKRHVLFCGTEVIQAKAACSGTVRAVVLQTGFNTA 419
            ||||||:||||||||.....:..||    ::.||.|||||:|||.:...|..|.|.|:.||..||
  Fly   463 MLTGESVPVTKTPLPSKRDMIFDKT----EHARHTLFCGTKVIQTRYIGSKKVLAFVINTGNITA 523

Human   420 KGDLVRSILYPKPVNFQLYRDAIRFLLCLVGTATIGMIYTLCVYVLSGEPPEEVVRKALDVITIA 484
            ||:|:||||||.||:::..:|:.:|:..|...|.:|.||||...:|.|..|.::..::||:|||.
  Fly   524 KGELIRSILYPPPVDYKFEQDSYKFIQFLAIIACVGFIYTLVTKILRGTDPVKIAVESLDLITIV 588

Human   485 VPPALPAALTTGIIYAQRRLKKRGIFCISPQRINVCGQLNLVCFDKTGTLTRDGLDLWGVV-SCD 548
            ||||||||:|.|..|||:|||...||||||:.|||.|.:|..|||||||||.||||:|||| ...
  Fly   589 VPPALPAAMTVGRFYAQKRLKTSEIFCISPRSINVAGSINCCCFDKTGTLTEDGLDMWGVVPKSS 653

Human   549 RNGFQEVHSFASGQALPWGPLCAAMASCHSLILLDGTIQGDPLDLKMFEATTWEMAFSGD--DFH 611
            .|.||  ....|...||:......|.:|||:.:|:|.:.||||||||||:|.||:..|.:  |..
  Fly   654 TNQFQ--IPLKSVDRLPFDHFLFGMVTCHSITILNGRMMGDPLDLKMFESTGWELEDSNNIPDTE 716

Human   612 IKGVPAHAMVVKP-------CRTAS--------QVPVE------GIA---------ILHQFPFSS 646
            ..|:....::.:|       ..|.|        |..|:      ||:         |:.:|||:|
  Fly   717 KYGILYPTILRQPRGGLSGMAETESGSKNEIKRQSSVDDLLATVGISPSQKNFDHGIVREFPFTS 781

Human   647 ALQRMTVIVQEMGGDRL--AFMKGAPERVASFCQPETVPTSFVSELQIYTTQGFRVIALAYKKLE 709
            |||||:|:.:.: .|::  .:.||:||.:...|:|:::|.::..:|..:..:|:|:||:|:|.|.
  Fly   782 ALQRMSVVTRCL-SDQVFNVYCKGSPEMLKKLCKPQSLPDNYSQQLSEFAKKGYRIIAIAFKALS 845

Human   710 NDHHAT---TLTRETVESDLIFLGLLILENRLKEETKPVLEELISARIRTVMITGDNLQTAITVA 771
            :..:.|   .|:||.||:::.|||.:|||||||.:|..|:..|.:|:|||:||||||:.|||:||
  Fly   846 HKMNYTKVQRLSREEVENNMEFLGFVILENRLKPDTTKVINALNAAKIRTIMITGDNILTAISVA 910

Human   772 RKSGMVSESQKVILIEA------------------------------------------------ 788
            |..|:||.||.||.:.|
  Fly   911 RDCGIVSPSQSVITVHADPIGDSANIQTNTGTECNFDNSSDKHYKLHYTLDLGSKTSRAYLFKSC 975

Human   789 -------------------------------NETTGS---SSASISWTLVEEKKHIMYGNQDNYI 819
                                           ||:|.|   |....|.:|...|....:.:.|..:
  Fly   976 FNSNLFDPETPEFTAQVGKTIFHMESTNSLVNESTSSYAESGLPTSDSLASVKTIDTWTHNDAEL 1040

Human   820 NIRDEVSDKGREGSYHFALTGKSFHVISQHFSSLLPKILINGTIFARMSPGQKSSLVEEFQKLDY 884
            .|:....:..|.....||:.||::.::..:|...:..:|..|:|:|||||.||.:||.|.|.|||
  Fly  1041 GIKHTPDESWRRQECIFAMDGKTWQIVKDYFPEEMEILLTRGSIYARMSPDQKQALVIELQNLDY 1105

Human   885 FVGMCGDGANDCGALKMAHVGISLSEQEASVASPFTSKTPNIECVPHLIKEGRAALVTSFCMFKY 949
            .|.|||||||||||||:||.||||||.|||:||||||:.|.|..|..:||||||||||||.:|||
  Fly  1106 CVAMCGDGANDCGALKVAHAGISLSETEASIASPFTSRNPTISAVLKVIKEGRAALVTSFGIFKY 1170

Human   950 MALYSMIQYVGVLLLYWETNSLSNYQFLFQDLAITTL----IGVTMNLNGAYPKLVPFRPAGRLI 1010
            ||.||::|::.|::||...::|::.|:|:.||.:.::    .|.|.:.:|   .||...|...||
  Fly  1171 MAAYSLVQFISVMILYSIDSNLTDKQYLYVDLGLISIFAFFFGKTESFDG---MLVEQVPLSSLI 1232

Human  1011 SPPLLLSVIFNILLSLAMHIAGFILVQRQPWYSV-----EIHSACTVQNESISELTMSPTAPEKM 1070
            |...|.|::.::.:..|..:..::.:.:|||:..     |.|..|
  Fly  1233 SSTPLASLLLHLTVVTAFQVTCWVHLHQQPWFKAFEPADEDHLGC-------------------- 1277

Human  1071 ESNSTFTSFENTTVWFLGTINCITVALVFSKGKPFRQPTYTNYIFVLVLIIQLGVCLFILFADIP 1135
                    |||.|::.:.:...|.:|.|||||.|:|:|.::|:...|..|:.|.:.::::.....
  Fly  1278 --------FENYTMFCISSFQYIILAFVFSKGAPYRKPLWSNWPLCLAFIVNLCIIVYLVLYPSD 1334

Human  1136 ELYRRLDLLCTPVL-WRASIVIMLSLNFIVSLVAEEAVIENRALWMMIKRCFGYQ---------S 1190
            .:.....|:..|.: :|..::...:.:||..:..|..::|    :::.|:   ||         |
  Fly  1335 WVASFFQLIVPPTMRFRYVMLAYGAASFICHIFVESFLVE----YLVFKK---YQVKREKNWVTS 1392

Human  1191 KSQYRIWQRDLANDPSWPPLNQ 1212
            |.:|...:.|::|..:|||:.:
  Fly  1393 KQKYMRLEHDISNIKNWPPITE 1414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP13A4	XP_047305019.1	P5-ATPase	59..184	CDD:463565	36/148 (24%)
		P-type_ATPase_cation	216..1058	CDD:319842	380/970 (39%)
anne	NP_001096849.1	P5-ATPase	158..296	CDD:463565	36/148 (24%)
		P-type_ATPase_cation	326..1281	CDD:319842	382/994 (38%)