Protein Alignment TRAF7 and MET30

DIOPT Version :10

• Sequence 1: NP_115647.2
• Gene: TRAF7 / 84231
• HGNCID: 20456
• Length: 670
• Species: Homo sapiens
• Sequence 2: NP_012218.1
• Gene: MET30 / 854765
• SGDID: S000001308
• Length: 640
• Species: Saccharomyces cerevisiae
• Alignment Length: 550
• Identity: 121/550 - (22%)
• Similarity: 191/550 - (34%)
• Gaps: 192/550 - (34%)

Human   295 DDRFHEMHVALAQKD----------------QEIAFLRSMLGKLSEKIDQLEKSL---------- 333
            |.:|...|.|..::|                ||.:.:..::.|.|...|::.|.:
Yeast   101 DIQFSPTHTACYKQDLKRTQEINANIAKLPLQEQSDIHHIISKYSNSNDKIRKLILDGILSTSCF 165

Human   334 ------------ELKFDVLDENQSKLSEDLMEF-------------RRDASMLNDE--------- 364
                        .:|.|.:.....:||..::.:             |:...:.:|:
Yeast   166 PQLSYISSLVTHMIKIDFISILPQELSLKILSYLDCQSLCNATRVCRKWQKLADDDRVWYHMCEQ 230

Human   365 --------------LSHI-NARLNMGILGSYDPQQI---------------FKCKGT-------- 391
                          |.|: .||:.....||.....|               ||.:..
Yeast   231 HIDRKCPNCGWGLPLLHMKRARIQQNSTGSSSNADIQTQTTRPWKVIYRERFKVESNWRKGHCRI 295

Human   392 --FVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYS 454
              |.||...|  |.:.....|||:||.|.||.:||..|. |..:.|.||...|..|.....||.:
Yeast   296 QEFKGHMDGV--LTLQFNYRLLFTGSYDSTIGIWDLFTG-KLIRRLSGHSDGVKTLYFDDRKLIT 357

Human   455 GSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSL-KAIKVWDIVGTELKLKKELTG 518
            ||.|.||.||:....:.::|.|.|.:.|.::.|...|:.|||. |.:|||.:   |.:....|.|
Yeast   358 GSLDKTIRVWNYITGECISTYRGHSDSVLSVDSYQKVIVSGSADKTVKVWHV---ESRTCYTLRG 419

Human   519 LNHWVRALVAAQSYLYSGSYQ--------TIKIWDIRTLDCIHVLQ------------------- 556
            ...||..:     .|:..|:.        ||::|||||..|:.|.:
Yeast   420 HTEWVNCV-----KLHPKSFSCFSCSDDTTIRMWDIRTNSCLKVFRGHVGQVQKIIPLTIKDVEN 479

Human   557 -----TSGGSV--------------------------YSIAVTNHHIVCGTYENLIHVWDIESKE 590
                 ||.||.                          .:|....|.:.|| .:|.|.:||:::.:
Yeast   480 LATDNTSDGSSPQDDPTMTDGADESDTPSNEQETVLDENIPYPTHLLSCG-LDNTIKLWDVKTGK 543

Human   591 QVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMIC-----------------TQT 638
            .:||..|||..|:.:|.    |..::.|.|:|.|::||.:.:..|                 ||:
Yeast   544 CIRTQFGHVEGVWDIAA----DNFRIISGSHDGSIKVWDLQSGKCMHTFNGRRLQRETQHTQTQS 604

Human   639 LLRHQGSVTALAVSRGRLFSGAVDSTVKVW 668
            |......:..:.:.....|||.....||::
Yeast   605 LGDKVAPIACVCIGDSECFSGDEFGCVKMY 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRAF7	NP_115647.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..97
		mRING-HC-C3HC3D_TRAF7	124..168	CDD:438306
		Sina	208..>269	CDD:460824
		DD_cGKI	282..322	CDD:473057	7/42 (17%)
		PRK03918	283..>373	CDD:235175	21/152 (14%)
		WD40	<387..668	CDD:441893	96/366 (26%)
		WD 1. /evidence=ECO:0000255	394..433		16/38 (42%)
		WD 2. /evidence=ECO:0000255	437..474		13/36 (36%)
		WD40 repeat	443..477	CDD:293791	11/33 (33%)
		WD 3. /evidence=ECO:0000255	477..513		12/36 (33%)
		WD40 repeat	482..517	CDD:293791	11/35 (31%)
		WD 4. /evidence=ECO:0000255	515..554		14/46 (30%)
		WD40 repeat	527..556	CDD:293791	11/36 (31%)
		WD 5. /evidence=ECO:0000255	557..594		12/62 (19%)
		WD40 repeat	562..596	CDD:293791	10/59 (17%)
		WD 6. /evidence=ECO:0000255	597..638		14/57 (25%)
		WD40 repeat	604..639	CDD:293791	11/51 (22%)
		WD 7. /evidence=ECO:0000255	641..669		5/27 (19%)
		WD40 repeat	646..668	CDD:293791	5/21 (24%)
MET30	NP_012218.1	F-box_SpPof1-like	183..228	CDD:438918	4/44 (9%)
		WD40	295..590	CDD:238121	87/310 (28%)
		WD40 repeat	305..340	CDD:293791	15/37 (41%)
		WD40 repeat	346..380	CDD:293791	11/33 (33%)
		WD40 repeat	385..418	CDD:293791	11/35 (31%)
		WD40 repeat	425..460	CDD:293791	11/39 (28%)
		WD40 repeat	488..549	CDD:293791	12/61 (20%)