DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TRAF7 and elgi

DIOPT Version :10

Sequence 1:NP_115647.2 Gene:TRAF7 / 84231 HGNCID:20456 Length:670 Species:Homo sapiens
Sequence 2:NP_648816.1 Gene:elgi / 39735 FlyBaseID:FBgn0283649 Length:315 Species:Drosophila melanogaster


Alignment Length:258 Identity:57/258 - (22%)
Similarity:89/258 - (34%) Gaps:79/258 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   121 FAEQPSVKLCCQLCCSVFKDPV-ITTCGHTFCRRC----ALKSEKCPVDNVKLTV--------VV 172
            |..:...:|.|.:|..|.:||: ...|.|.|||.|    ..:...||||...||.        ::
  Fly     8 FQGEVDEELTCPICSGVLEDPLQAVMCEHAFCRGCINEWLTRQPTCPVDRNSLTTANLRAVPRIL 72

Human   173 NNIAVAEQIGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNP 237
            .|:     :..|.|.|.:.               |.||...:||.|...|...|.:.|.|     
  Fly    73 RNL-----LSRLSITCDNA---------------PYGCTAVLKLDAYNSHLDECIHNPKR----- 112

Human   238 SCPPLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMH 302
               |.          .||.        ||.|...:|..:.|  .|               ..|:.
  Fly   113 ---PF----------PCEK--------GCGFDIPKDELKDH--NC---------------VRELR 139

Human   303 VALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLNDEL 365
            ..:.::.:::..|:|.|......|::|::.|:|..|.:  ...::|...|....| .|..||:
  Fly   140 TLIVKQTEKMGELKSELTDQQLTINELKRELQLFKDFM--RAMRVSNPAMRAIAD-QMERDEV 199

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TRAF7NP_115647.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 49..97
mRING-HC-C3HC3D_TRAF7 124..168 CDD:438306 16/48 (33%)
Sina 208..>269 CDD:460824 14/60 (23%)
DD_cGKI 282..322 CDD:473057 5/39 (13%)
PRK03918 283..>373 CDD:235175 15/83 (18%)
WD40 <387..668 CDD:441893
WD 1. /evidence=ECO:0000255 394..433
WD 2. /evidence=ECO:0000255 437..474
WD40 repeat 443..477 CDD:293791
WD 3. /evidence=ECO:0000255 477..513
WD40 repeat 482..517 CDD:293791
WD 4. /evidence=ECO:0000255 515..554
WD40 repeat 527..556 CDD:293791
WD 5. /evidence=ECO:0000255 557..594
WD40 repeat 562..596 CDD:293791
WD 6. /evidence=ECO:0000255 597..638
WD40 repeat 604..639 CDD:293791
WD 7. /evidence=ECO:0000255 641..669
WD40 repeat 646..668 CDD:293791
elgiNP_648816.1 mRING-HC-C3HC3D_Nrdp1 15..57 CDD:438296 15/41 (37%)
USP8_interact 137..315 CDD:430333 15/66 (23%)
Blue background indicates that the domain is not in the aligned region.

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