Protein Alignment TRAF7 and SCAP

DIOPT Version :10

• Sequence 1: NP_115647.2
• Gene: TRAF7 / 84231
• HGNCID: 20456
• Length: 670
• Species: Homo sapiens
• Sequence 2: NP_788277.1
• Gene: SCAP / 35529
• FlyBaseID: FBgn0033052
• Length: 1276
• Species: Drosophila melanogaster
• Alignment Length: 353
• Identity: 86/353 - (24%)
• Similarity: 137/353 - (38%)
• Gaps: 114/353 - (32%)

Human   286 GLKEFLQQTDDRFHEMHVALAQKDQEIAFL-----RSMLGKLSEKID--QLE-----KSLELKFD 338
            ||.:...|.|          |:::|.|..:     |.::.:|:.::|  :||     |.::..|
  Fly   972 GLLKCAYQED----------AKRNQGITHIHLNGDRVIVARLNGRLDFYRLETYYKGKQIDWGF- 1025

Human   339 VLDENQSKLSEDLMEFRRDASMLNDELSHINARLNMGILGSYDPQQIFKC--------------- 388
                        ...:||         :|:... :.|.||....||  :|
  Fly  1026 ------------TSAYRR---------THVRTG-STGSLGLMLQQQ--RCQQEASQKTTKEEMKI 1066

Human   389 --KGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYK-CQKTLEGHDGIVLALCIQ-- 448
              :|..:.||.|:.|:.|  :.|::|:||.|.|:||:  |.... .:.||.||.|.|..|.:.
  Fly  1067 TLEGVRLAHQQPITCMQV--VNDMVFTGSQDHTLKVY--CLNKSDVEYTLHGHCGPVTCLFVDRW 1127

Human   449 -----GCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPV-CTLVSSHNVLFSGSLKAIKVWDIVG 507
                 |    |||.|..:.|||:.....:..|:|||..| |...:...|:..|:.:.|.||:...
  Fly  1128 QPGTGG----SGSQDGLLCVWDLFTGACMYNIQAHDGAVSCLACAPSYVISLGTDERICVWERFQ 1188

Human   508 TELKLKKELTGL---NHWVRALVAAQSYLYSGSYQTIKIWDIRT--------LD------CIHVL 555
            ..|     ||.:   |.:...|:...|.|.:....::.:||:||        ||      |..::
  Fly  1189 GNL-----LTTINISNAYSSLLMLTPSLLVTSKMGSLIVWDVRTGQPAREVKLDFANLQLCPKIM 1248

Human   556 QTSGGSVYSIAVTNHHIVCGTYENLIHV 583
            ..:..||          || .|.|.|.|
  Fly  1249 MLACDSV----------VC-DYGNEIRV 1265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRAF7	NP_115647.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..97
		mRING-HC-C3HC3D_TRAF7	124..168	CDD:438306
		Sina	208..>269	CDD:460824
		DD_cGKI	282..322	CDD:473057	8/40 (20%)
		PRK03918	283..>373	CDD:235175	17/98 (17%)
		WD40	<387..668	CDD:441893	64/240 (27%)
		WD 1. /evidence=ECO:0000255	394..433		14/39 (36%)
		WD 2. /evidence=ECO:0000255	437..474		13/43 (30%)
		WD40 repeat	443..477	CDD:293791	10/40 (25%)
		WD 3. /evidence=ECO:0000255	477..513		11/36 (31%)
		WD40 repeat	482..517	CDD:293791	8/35 (23%)
		WD 4. /evidence=ECO:0000255	515..554		13/55 (24%)
		WD40 repeat	527..556	CDD:293791	9/42 (21%)
		WD 5. /evidence=ECO:0000255	557..594		8/27 (30%)
		WD40 repeat	562..596	CDD:293791	7/22 (32%)
		WD 6. /evidence=ECO:0000255	597..638
		WD40 repeat	604..639	CDD:293791
		WD 7. /evidence=ECO:0000255	641..669
		WD40 repeat	646..668	CDD:293791
SCAP	NP_788277.1	Sterol-sensing	390..543	CDD:463544
		WD40	878..1185	CDD:475233	63/255 (25%)
		WD40 repeat	887..942	CDD:293791
		WD40 repeat	945..983	CDD:293791	4/20 (20%)
		WD40 repeat	989..1070	CDD:293791	16/105 (15%)
		WD40 repeat	1079..1114	CDD:293791	13/38 (34%)
		WD40 repeat	1120..1157	CDD:293791	10/40 (25%)
		WD40 repeat	1162..1196	CDD:293791	10/38 (26%)
		WD40 repeat	1201..1233	CDD:293791	7/31 (23%)