Protein Alignment TRAF7 and Traf4

DIOPT Version :10

• Sequence 1: NP_115647.2
• Gene: TRAF7 / 84231
• HGNCID: 20456
• Length: 670
• Species: Homo sapiens
• Sequence 2: NP_477416.1
• Gene: Traf4 / 33638
• FlyBaseID: FBgn0026319
• Length: 486
• Species: Drosophila melanogaster
• Alignment Length: 450
• Identity: 99/450 - (22%)
• Similarity: 148/450 - (32%)
• Gaps: 199/450 - (44%)

Human    58 RTPSSSSTLAYSPRDEEDSMPPISTPR-------------RSDSAISVRSLHSESSMSL---RST 106
            |.....|||| ||      :||.:.||             ||.|: :|.|.||.|..|.   .:.
  Fly    22 RNSKDCSTLA-SP------VPPPTPPRNKTTSGSGNCATSRSSSS-TVSSSHSSSHSSPTPGNNN 78

Human   107 FSLPEEEEE------PEP------LVF------------------------------------AE 123
            .::|..|.|      |:|      |||                                    |:
  Fly    79 NNMPITELEQIIYPGPDPKHIMGSLVFCIHHKQGCKWSDELRKLKGHLNACKHDATQCPNKCGAQ 143

Human   124 QPSVKL-------C------CQLCCSVF-------------KDPVI--TTCGHTFCR-------- 152
            .|.:.:       |      |:.|.|.|             ::||.  ..||....|
  Fly   144 IPRIMMTDHLQYTCTMRRTRCEFCQSEFSGAGLEEHNGSCGQEPVYCEAKCGQRILRGRMTLHKS 208

Human   153 -RCALKSEKCPVDNVKLTVVVNNIAVAEQIGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKL 216
             .||.:..:|                        .||:..           |..|      |:.|
  Fly   209 KDCAKRLRRC------------------------AHCQRE-----------FSAD------TLPL 232

Human   217 SARKDHEGSCDYRPVRCPNNPSCPPLLRMNLEAHLK-ECEH--IKCPHSKYGCTFIGNQDTYETH 278
                 |...|...|:.||......|:.|..|||||: ||:.  :.|...:.||.|.|.:...|.|
  Fly   233 -----HAAQCPRAPLACPQRCDAGPIPRGELEAHLRDECQSLAVSCSFKEAGCRFKGPRQMLEAH 292

Human   279 LETCRFEGLKEFLQQTDDRFHEMHVALAQKD-QEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDE 342
            ||:.....|            .:.|||:.:. |:|..|:|.:.|||     :..:..|.:.:.|.
  Fly   293 LESNAAAHL------------SLMVALSSRQGQQIQMLKSAVSKLS-----INYTGTLLWKITDW 340

Human   343 NQSKLSE----DLME------------FRRDASM-LN----DELSHINARLNMGILGSYD 381
            : :|::|    |.:|            ::..||| ||    .|.:|::..:.: :.|.||
  Fly   341 S-AKMAEARGKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIKV-LPGEYD 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRAF7	NP_115647.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..97		16/51 (31%)
		mRING-HC-C3HC3D_TRAF7	124..168	CDD:438306	14/80 (18%)
		Sina	208..>269	CDD:460824	19/63 (30%)
		DD_cGKI	282..322	CDD:473057	8/40 (20%)
		PRK03918	283..>373	CDD:235175	24/111 (22%)
		WD40	<387..668	CDD:441893
		WD 1. /evidence=ECO:0000255	394..433
		WD 2. /evidence=ECO:0000255	437..474
		WD40 repeat	443..477	CDD:293791
		WD 3. /evidence=ECO:0000255	477..513
		WD40 repeat	482..517	CDD:293791
		WD 4. /evidence=ECO:0000255	515..554
		WD40 repeat	527..556	CDD:293791
		WD 5. /evidence=ECO:0000255	557..594
		WD40 repeat	562..596	CDD:293791
		WD 6. /evidence=ECO:0000255	597..638
		WD40 repeat	604..639	CDD:293791
		WD 7. /evidence=ECO:0000255	641..669
		WD40 repeat	646..668	CDD:293791
Traf4	NP_477416.1	PLN03086	<109..206	CDD:178635	12/96 (13%)
		zf-TRAF	233..292	CDD:280357	20/58 (34%)
		MATH_TRAF4	331..479	CDD:239750	15/69 (22%)