DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TRAF7 and sel-10

DIOPT Version :10

Sequence 1:NP_115647.2 Gene:TRAF7 / 84231 HGNCID:20456 Length:670 Species:Homo sapiens
Sequence 2:NP_506421.1 Gene:sel-10 / 179878 WormBaseID:WBGene00004767 Length:587 Species:Caenorhabditis elegans


Alignment Length:481 Identity:119/481 - (24%)
Similarity:188/481 - (39%) Gaps:117/481 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   243 LRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFE----------------GLKEFL 291
            ||..:|.|.:. :.:.|...:.|...:.|...|:. |:..:..                |::||.
 Worm   111 LRAIIEPHFQR-DFLSCLPVELGMKILHNLTGYDL-LKVAQVSKNWKLISEIDKIWKSLGVEEFK 173

Human   292 QQTD--DRFHEMHVALAQKDQEIA------------------FLR-SMLGKLSEKIDQLEKSLEL 335
            ...|  ||     |..|.:...||                  ||: ...|.:.|:  ..:||..|
 Worm   174 HHPDPTDR-----VTGAWQGTAIAAGVTIPDHIQPCDLNVHRFLKLQKFGDIFER--AADKSRYL 231

Human   336 KFDVLDENQSKLSEDLMEFRRDASMLNDELSHINARLNMG----ILGSYDPQQIFKC--KG---- 390
            :.|.:::|.:  :..:|    .:::|.....|:...:.:.    :.||.|......|  ||    
 Worm   232 RADKIEKNWN--ANPIM----GSAVLRGHEDHVITCMQIHDDVLVTGSDDNTLKVWCIDKGEVMY 290

Human   391 TFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSG 455
            |.|||.|.||...:...|..:.|||:|:|:|||.| .......||:||...|..:.:.|..|.:|
 Worm   291 TLVGHTGGVWTSQISQCGRYIVSGSTDRTVKVWST-VDGSLLHTLQGHTSTVRCMAMAGSILVTG 354

Human   456 SADCTIIVWDIQNLQKVNTIRAHDNPV-CTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGL 519
            |.|.|:.|||:::.:.:.|:..|...| |       |.|.|:.                      
 Worm   355 SRDTTLRVWDVESGRHLATLHGHHAAVRC-------VQFDGTT---------------------- 390

Human   520 NHWVRALVAAQSYLYSGSYQ-TIKIWDIRTLDCIHVLQTSGGSVYSIAV-TNHHIVC-GTYENLI 581
                         :.||.|. |:|||:..|..||..|......|||:.. :...||| |:.:..|
 Worm   391 -------------VVSGGYDFTVKIWNAHTGRCIRTLTGHNNRVYSLLFESERSIVCSGSLDTSI 442

Human   582 HVWDI---ESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQ 643
            .|||.   |.:|.|..|.||......:.:..    ..:.|.:.|..:|||.:....|...|..|:
 Worm   443 RVWDFTRPEGQECVALLQGHTSLTSGMQLRG----NILVSCNADSHVRVWDIHEGTCVHMLSGHR 503

Human   644 GSVTALA-VSRGRLFSGAVDSTVKVW 668
            .::|:|. ..|..:.:.:.|.|||:|
 Worm   504 SAITSLQWFGRNMVATSSDDGTVKLW 529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TRAF7NP_115647.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 49..97
mRING-HC-C3HC3D_TRAF7 124..168 CDD:438306
Sina 208..>269 CDD:460824 6/25 (24%)
DD_cGKI 282..322 CDD:473057 13/76 (17%)
PRK03918 283..>373 CDD:235175 22/126 (17%)
WD40 <387..668 CDD:441893 84/294 (29%)
WD 1. /evidence=ECO:0000255 394..433 15/38 (39%)
WD 2. /evidence=ECO:0000255 437..474 12/36 (33%)
WD40 repeat 443..477 CDD:293791 10/33 (30%)
WD 3. /evidence=ECO:0000255 477..513 6/36 (17%)
WD40 repeat 482..517 CDD:293791 5/35 (14%)
WD 4. /evidence=ECO:0000255 515..554 10/39 (26%)
WD40 repeat 527..556 CDD:293791 10/29 (34%)
WD 5. /evidence=ECO:0000255 557..594 14/41 (34%)
WD40 repeat 562..596 CDD:293791 14/38 (37%)
WD 6. /evidence=ECO:0000255 597..638 8/40 (20%)
WD40 repeat 604..639 CDD:293791 6/34 (18%)
WD 7. /evidence=ECO:0000255 641..669 9/29 (31%)
WD40 repeat 646..668 CDD:293791 7/22 (32%)
sel-10NP_506421.1 F-box_SF 107..165 CDD:459239 9/55 (16%)
WD40 248..530 CDD:238121 90/329 (27%)
WD40 repeat 259..294 CDD:293791 7/34 (21%)
WD40 repeat 300..336 CDD:293791 13/36 (36%)
WD40 repeat 341..375 CDD:293791 11/33 (33%)
WD40 repeat 382..415 CDD:293791 14/74 (19%)
WD40 repeat 421..460 CDD:293791 14/38 (37%)
WD40 repeat 468..500 CDD:293791 6/35 (17%)
WD40 495..>572 CDD:475233 11/35 (31%)
WD40 repeat 506..529 CDD:293791 7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.