Protein Alignment TRAF7 and mec-15

DIOPT Version :10

• Sequence 1: NP_115647.2
• Gene: TRAF7 / 84231
• HGNCID: 20456
• Length: 670
• Species: Homo sapiens
• Sequence 2: NP_496207.1
• Gene: mec-15 / 174587
• WormBaseID: WBGene00003177
• Length: 406
• Species: Caenorhabditis elegans
• Alignment Length: 371
• Identity: 80/371 - (21%)
• Similarity: 134/371 - (36%)
• Gaps: 120/371 - (32%)

Human   337 FDVLDENQSKLSEDLMEFRRDASMLND-------------------ELSHINARLNMGILGSYDP 382
            |..|.:.| .::|..:..||..::|||                   ||.|          ..|:|
 Worm    21 FTYLPQRQ-LITEIPLVCRRFNTILNDDKFWSRRIRTEQKVRLPDCELKH----------PEYEP 74

Human   383 QQIFKCKGTFVGH-QGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446
            ::.|     :..| |...|                    :.|:|.|..    |..||...|.::.
 Worm    75 KKSF-----YAMHRQRDRW--------------------RAWETQTVI----TAPGHSATVDSVM 110

Human   447 I------QGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKAIKVWDI 505
            :      |.|  .|||.|.||.:|.|:|.:  |......||                     |.:
 Worm   111 LFENNNKQFC--LSGSRDRTIRLWSIENAR--NGEDTEQNP---------------------WTV 150

Human   506 VGTELKLKKELTGLNHWV--RALVAAQSYLYSGSY-QTIKIWDI------RTLDCIHVLQTSGGS 561
            .       |:.|..:.|:  .|..:..:..|:.|: .|:|.|.|      :.|:.::|  .|...
 Worm   151 A-------KDDTAHSGWIWNMAQESTSTNFYTTSWDSTVKSWHITDNGALQNLNSVNV--GSAAQ 206

Human   562 VYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLR 626
            ..|.:...:.:||.|:...:.|.|..:.:.|.....|...|.||||    ...|:|::..||.:.
 Worm   207 CISCSGNENEVVCTTFAKRVAVIDSRTFQVVADHKLHKRAVIALAV----QGDKIFTSGEDRLMM 267

Human   627 VWSMDNMICTQTLLRHQGSVTA----LAVSRGRLFSGAVDSTVKVW 668
            :  :|....::.:| .:.|.||    |::...:|.:...|..||::
 Worm   268 M--VDRRNFSKPVL-FEYSPTAYKSCLSLQCNQLLTSTSDGKVKLY 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRAF7	NP_115647.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..97
		mRING-HC-C3HC3D_TRAF7	124..168	CDD:438306
		Sina	208..>269	CDD:460824
		DD_cGKI	282..322	CDD:473057
		PRK03918	283..>373	CDD:235175	12/54 (22%)
		WD40	<387..668	CDD:441893	65/300 (22%)
		WD 1. /evidence=ECO:0000255	394..433		6/39 (15%)
		WD 2. /evidence=ECO:0000255	437..474		14/42 (33%)
		WD40 repeat	443..477	CDD:293791	12/39 (31%)
		WD 3. /evidence=ECO:0000255	477..513		3/35 (9%)
		WD40 repeat	482..517	CDD:293791	2/34 (6%)
		WD 4. /evidence=ECO:0000255	515..554		10/47 (21%)
		WD40 repeat	527..556	CDD:293791	8/35 (23%)
		WD 5. /evidence=ECO:0000255	557..594		8/36 (22%)
		WD40 repeat	562..596	CDD:293791	7/33 (21%)
		WD 6. /evidence=ECO:0000255	597..638		11/40 (28%)
		WD40 repeat	604..639	CDD:293791	9/34 (26%)
		WD 7. /evidence=ECO:0000255	641..669		8/32 (25%)
		WD40 repeat	646..668	CDD:293791	7/25 (28%)
mec-15	NP_496207.1	F-box_SF	9..57	CDD:459239	9/36 (25%)
		WD40	88..322	CDD:475233	63/288 (22%)
		WD40 repeat	106..154	CDD:293791	17/79 (22%)
		WD40 repeat	162..197	CDD:293791	7/34 (21%)
		WD40 repeat	204..241	CDD:293791	7/36 (19%)
		WD40 repeat	247..286	CDD:293791	12/45 (27%)
		WD40 repeat	290..310	CDD:293791	5/19 (26%)