DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ALA3 and CG33298

DIOPT Version :9

Sequence 1:	NP_176191.1	Gene:	ALA3 / 842275	AraportID:	AT1G59820	Length:	1213	Species:	Arabidopsis thaliana
Sequence 2:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster

Alignment Length:	1383	Identity:	427/1383 - (30%)
Similarity:	659/1383 - (47%)	Gaps:	283/1383 - (20%)

- Green bases have known domain annotations that are detailed below.

plant     8 SVDSSAT----HQRTPSRTVTLGHI-QPQAP--------------------TYRTVYCN------ 41
            |..:|||    |.|..||:.::..: :.:||                    :||||..|
  Fly   175 SAPTSATGGRGHSRQASRSESIYTLRRTEAPPWWKRLTLCNYNTGDKFEERSYRTVVPNHTVPPK 239

plant    42 ----DRESNQPVRFKGNSISTTKYNVFTFLPKGLFEQFRRIANIYFLGISCLSMTP-ISPVSPIT 101
                |..:.|   |.||.|.||||.:.:|:||.|.|||.|:||:||:.|..|:..| ||......
  Fly   240 TPKRDHPNGQ---FVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEV 301

plant   102 NVAPLSMVLLVSLIKEAFEDWKRFQNDMSINNSTVEIL--QDQQWVSIPWRKLQVGDIVKIKKDG 164
            .:.|:..||.|:.:|:.|||.:|..:|..|||:|..:.  :.:::..:.|::|:|||||.:..:.
  Fly   302 AMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGDIVHLSNNE 366

plant   165 FFPADILFMSSTNSDGICYVETANLDGETNLKIR---KALERTWDYLVPEKAYEFKGEIQCEQPN 226
            ..|||||.:.:::..|:||::|.:||||||||.|   :..|......||.|   |...::.:.|.
  Fly   367 TVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSK---FVSRVEADAPT 428

plant   227 NSLYTFTGNLV-VQKQTLPLSPDQLLLRGCSLRNTEYIVGAVVFTGHETKVMMNAMNAPSKRSTL 290
            ..||.|.|.|: ...:.:|:|.:.||||...|:||:||.|.||:.|||||.|:|......|||.:
  Fly   429 TKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQV 493

plant   291 EKKLDKLIITIFCVLVTMCLIGAIGC----SIVTDREDKYLGLHNSDWEYRNGL---MIGFFTFF 348
            |::::..:|....:|:.:|::|||||    |..|.....||.        .|.|   |...:.|:
  Fly   494 EQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFPVPYLP--------PNKLTANMESMWIFW 550

plant   349 TLVTLFSSIIPISLYVSIEMIKFIQSTQFINRDLNMYHAETNTPASARTSNLNEELGQVEYIFSD 413
            |.:.:...:||:||||:||:.|.:| ...|:.:::::.||||.....|..|:.|||||:::||:|
  Fly   551 TYIVILQVMIPLSLYVTIELCKILQ-VFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTD 614

plant   414 KTGTLTRNLMEFFKCSIGGVSYGCGVTEIEKGIAQRHGLKVQEEQRSTGAIREKGFNFDDPRLMR 478
            ||||||.|.|.|.:|.:.|..|....:|:|| |..:.|..      :...|.....|.|..:|.:
  Fly   615 KTGTLTENKMIFRRCVVNGSDYNHPPSELEK-IYSKPGAP------APPLIPNDNLNSDMAQLTQ 672

plant   479 GAWRNEPNPDLCKELFRCLAICHTVL----PEGD------------------------------- 508
            |.:.. |:....:|....||||:||:    |..|
  Fly   673 GTYLT-PHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLA 736

plant   509 ----------------------------------------------------------------- 508

  Fly   737 SSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSS 801

plant   509 ---------ESP------------------------EKI-------------------------- 514
                     |||                        .||
  Fly   802 AESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKTGTI 866

plant   515 --------VYQAASPDEAALVTAAKNFGFFFYRRTPTMVYVRESHVEKMGKIQDVAYEILNVLEF 571
                    :|:|.||||.|||.||.::......|:|..:.|   .:...|..::  ||||.||.|
  Fly   867 YRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILV---SMPMAGATRE--YEILKVLPF 926

plant   572 NSTRKRQSVVCR-FPDGRLVLYCKGADNVIFERLA----NGMDDV-RKVTREHLEHFGSSGLRTL 630
            :|:||..|:|.| .....:|||.||||:.|...|.    |..:.: |:.|::.|:.:...|||.|
  Fly   927 DSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYAREGLRIL 991

plant   631 CLAYKDLNPETYDSWNEKFIQAKSALRDREKKLDEVAELIEKDLILIGSTAIEDKLQEGVPTCIE 695
            .:|.:.||...|..|..:..:.:.:|.:||::|.:....:|.:|.|:|:|.|||:||:|||..|.
  Fly   992 VMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIA 1056

plant   696 TLSRAGIKIWVLTGDKMETAINIAYACNLINNEMKQFVISSETDAIREAEERGDQVEIARVIKEE 760
            :|..|||.:|||||||.||||||||:..|...:|:...:::.:   |:|.|......:..:..::
  Fly  1057 SLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARS---RDAAETAINFYLTDMENDK 1118

plant   761 VKREL--KKSLEEAQHSLHTVAGPKLSLVIDGKCLMYALDPSLRVML--LSLSLNCTSVVCCRVS 821
            ....|  .:||.:.|.          :||:|||.|.:.|||..:::|  |.||..|.||:|||.:
  Fly  1119 TTSTLGYGQSLRKKQR----------ALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRST 1173

plant   822 PLQKAQVTSLVRKGAQKITLSIGDGANDVSMIQAAHVGIGISGMEGMQAVMASDFAIAQFRFLTD 886
            |||||.:..:|::.....||:||||||||||||.|.||:||||.||||||||:||.:.:||:|..
  Fly  1174 PLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLER 1238

plant   887 LLLVHGRWSYLRICKVVMYFFYKNLTFTLTQFWFTFRTGFSGQRFYDDWFQSLFNVVFTALPVIV 951
            |||.||.|.|.|:.::::||||||..|....||:....|||||...|..:..|:|::||:||.:.
  Fly  1239 LLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLA 1303

plant   952 LGLFEKDVSASLSKRYPELYREGIRNSFFK----WRVVAVWATSAVYQSLVCYLFVTTSSFGAVN 1012
            :|:::|.|:..|..:.|.||:.|.....::    |.::    ..|:|||||.: ||...::...:
  Fly  1304 IGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLIL----LDALYQSLVIF-FVALCAYAESD 1363

plant  1013 SSGKVFGLWDVSTMVFTCLVIAVNVRILLMSNSITRWHYITVGGSILAWLVFAFVYCGIMTPHDR 1077
                 .|:|:..|.:....:.|..|...:...|.|..|.:::..|:.::.:||.||..:......
  Fly  1364 -----VGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFG 1423

plant  1078 NENVYFVIYVLMSTFYFYFTLLLVPIVSLLGDFIFQGVERWFFPYDYQIVQEIHRHESDASKADQ 1142
            ..:.|:||:|..::...:..::|..:|::|...:...|.....|.|...|  |.:.:.:.|:.:.
  Fly  1424 VRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKV--ILQSKRERSRGEA 1486

plant  1143 LEVENELTPQEARSYAIS 1160
            |.|....:...:..|.|:
  Fly  1487 LLVTWSRSTSASSIYRIT 1504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ALA3	NP_176191.1	ATPase-Plipid	51..1129	CDD:273734	404/1272 (32%)
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	26/52 (50%)
		ATPase-Plipid	250..1473	CDD:273734	403/1270 (32%)
		E1-E2_ATPase	302..>394	CDD:278548	32/91 (35%)
		Cation_ATPase	<880..965	CDD:289987	35/89 (39%)
		HAD_like	<1177..1240	CDD:304363	37/62 (60%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	75/254 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830