DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASP9 and Strica

DIOPT Version :9

Sequence 1:	XP_011540575.1	Gene:	CASP9 / 842	HGNCID:	1511	Length:	421	Species:	Homo sapiens
Sequence 2:	NP_001260718.1	Gene:	Strica / 35528	FlyBaseID:	FBgn0033051	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	310	Identity:	79/310 - (25%)
Similarity:	128/310 - (41%)	Gaps:	65/310 - (20%)

- Green bases have known domain annotations that are detailed below.

Human   114 EIRKPEVLRPETPRP-VDIGSGG-----FGDVGALESLRGNADLAYILS--------MEPCGHCL 164
            ::.|| :....||:| :.:||.|     ...|...:..:|....:..:|        ::| ....
  Fly   254 QVDKP-LSSTATPKPFISLGSSGGTKPKVTAVAQSQDAQGTISTSLGISKSSLTKNKLKP-ARVY 316

Human   165 IINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGD---LTAKKMVLALLELAQQDHGA 226
            |.|:..|..::  ..|.||..|.:.||..|..|...|||..|   :|.||.|..|.....:|..|
  Fly   317 IFNHERFDNKN--EFRKGSAQDVKVLRATFEQLKCKVEVITDATLVTIKKTVRMLQTKDFEDKSA 379

Human   227 LDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQ 291
            |   |:||||||.:...:......|..|.     :.:..|....   :|..||||.|:|||.|:.
  Fly   380 L---VLVILSHGTRHDQIAAKDDDYSLDD-----DVVFPILRNR---TLKDKPKLIFVQACKGDC 433

Human   292 KDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRD 356
            :..||...:..|.    ||                           |::|...|||:.||||:|
  Fly   434 QLGGFMTDAAQPN----GS---------------------------PNEILKCYSTYEGFVSFR- 466

Human   357 PKSGSWYVETLDDIFEQWAHSEDLQSLLLRVSAAFLCKGEGRLLRGSVSS 406
            .:.|:.:::||.:...:...:.|:.::::.|......:.:.|.: .||:|
  Fly   467 TEDGTPFIQTLCEALNRSGKTSDIDTIMMNVRQVVKMQSKDRQI-PSVTS 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASP9	XP_011540575.1	CARD_CASP9	17..90	CDD:176740
CASP9	XP_011540575.1	CASc	152..397	CDD:237997	65/255 (25%)
Strica	NP_001260718.1	CASc	311..523	CDD:294037	68/252 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6822
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760