Protein Alignment SETD3 and Setd3

DIOPT Version :10

• Sequence 1: NP_115609.2
• Gene: SETD3 / 84193
• HGNCID: 20493
• Length: 594
• Species: Homo sapiens
• Sequence 2: NP_727144.1
• Gene: Setd3 / 31638
• FlyBaseID: FBgn0052732
• Length: 537
• Species: Drosophila melanogaster
• Alignment Length: 553
• Identity: 185/553 - (33%)
• Similarity: 273/553 - (49%)
• Gaps: 81/553 - (14%)

Human     1 MGK--KSRVKT-----QKSGTGATATVSPKEI----------------------LN-LTSELLQK 35
            |||  |...||     |....|.||:.|...:                      || |..|||..
  Fly     1 MGKNTKRNKKTKQQQQQPQQNGVTASASGTAVEDFEDQQAASSLPSLNGKKRSQLNKLVEELLDL 65

Human    36 CSSPAPGPGKEWEEYVQIRTLVEKIRKKQKGLSVTFDGKREDYFPD----LMK------WASENG 90
            .......|.:||::|.|::.|:::|...::.||.....:..| .||    |.|      ||.:.|
  Fly    66 VEKQPANPNEEWKQYGQLQELLKQIMILEEPLSQAVCPQISD-SPDDQTRLAKVEAFSAWAKDGG 129

Human    91 ASVEGFEMVNFKEEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNI 155
            ...||.|:..|.....||||||.:..:||.|.|||||:::.|:..:..|     ..::.||. ::
  Fly   130 VHSEGLEIAIFPGYQLGLRATRPLAKDELVLSVPRKLILSEENNSDCRL-----FGKMTQAT-HL 188

Human   156 ALAFHLLCERASPN-SFWQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAY 219
            .||:.|:.|:.... |.|:|||..||::|:|.|||...::..|:.|.|......|.:..|:|||:
  Fly   189 NLAYDLVIEKIRGEFSEWRPYIDVLPAKYNTVLYFTTKQMELLRGTAAAALAMRQCRVIAKQYAF 253

Human   220 FYKVIQT----------HPHANKLPLKDSFT-----YEDYRWAVSSVMTRQNQIP-----TEDGS 264
            .||...|          ||....|    .||     |:.||||||:||||||.:|     :|||.
  Fly   254 LYKYAHTMTEPSTGNRSHPGERGL----FFTQHGLCYKLYRWAVSTVMTRQNLVPSEKQESEDGP 314

Human   265 RVTLALIPLWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAEFVIHSGFFF 329
            ::..||||.|||.||..|.||:.|.....:.||.|.:....|||.:|:||.|||.:.::|:||..
  Fly   315 KLISALIPYWDMANHRPGKITSFYATVSRQLECTAQEAVNTGEQFFIYYGDRSNTDLLVHNGFVD 379

Human   330 DNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHFTEPPISAQLLAFLRVFCMTEEE 394
            .||:.|.|.|::|:|.:|.|.|.:|.:|.:..|..::...:......||.:||||:|||.|:.|:
  Fly   380 PNNTKDYVNIRVGLSLTDALAAKRASILDKLNIRHTAELRVLPAPDFISKELLAFVRVFKMSAEQ 444

Human   395 LKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSV 459
            | :|...|  :||...|.:.:..:..|:|.:.|.|||||..|||..:...:.|...|   .:|.:
  Fly   445 L-DHWCSD--LDRAGDLLHIDCALETDHETRTWQFLEDRLKLLLAVFNKEMHEADEV---KELEL 503

Human   460 RAKMAIKLRLGEKEILEKAVKSAAVNREYYRQQ 492
            :....|:|.|.....||:::.:.|:.   |.|:
  Fly   504 KDGQEIELMLFLYRRLERSILAGALQ---YAQE 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SETD3	NP_115609.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		10/27 (37%)
		SET_SETD3	80..329	CDD:380953	106/279 (38%)
		Rubis-subs-bind	344..475	CDD:462737	41/130 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	549..594
Setd3	NP_727144.1	SET_SETD3	119..378	CDD:380953	101/268 (38%)
		Rubis-subs-bind	394..524	CDD:462737	43/135 (32%)