Protein Alignment CHD6 and kis

DIOPT Version :10

• Sequence 1: XP_016883588.1
• Gene: CHD6 / 84181
• HGNCID: 19057
• Length: 2716
• Species: Homo sapiens
• Sequence 2: NP_001137761.1
• Gene: kis / 33185
• FlyBaseID: FBgn0266557
• Length: 5517
• Species: Drosophila melanogaster
• Alignment Length: 3624
• Identity: 1095/3624 - (30%)
• Similarity: 1534/3624 - (42%)
• Gaps: 1150/3624 - (31%)

Human    14 SNLKVLNHSPMSDASVNFDYKSPSPFDCSTDQEEKIE-DVASHCLPQKDLY----TAEEEAAT-- 71
            |||      |:.::|   ..::.|......::|.:|. |.|:..:..|..|    |.:|::..
  Fly  1593 SNL------PLDESS---QLEASSSTSAVAEKERQISTDAANAAMSSKPNYVYINTGDEDSMVVQ 1648

Human    72 -LFPRKMTSHNGMEDSGGGGTGVKKKRKKKEP------------------GDQ----EGAAKGSK 113
             :...:|.....:.|        |.|.|..||                  ||:    ||.:|  |
  Fly  1649 LVLAMRMGKRELILD--------KPKEKAPEPKQDEEKSELDEATTDKPEGDEKFKTEGESK--K 1703

Human   114 DREPKPKRK----------REPKEPKEPRKAKEPKKAKEHKEPKQKDG-AKKARKPREASGTKEA 167
            |.....:.|          :|..||.:.:|:.|..|.|:..|...:.| :.|..||.|.|.|.:.
  Fly  1704 DLTDSEETKLESSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKESKPEEQSETVKT 1768

Human   168 KEKRSCTDSAARTKSRKASKEQGPTPVEKKKKGKRKSETTVESLEL------DQGLTNPSLRSPE 226
            :|            :.||.:|...:.|......| :.||.:|.:|:      ||...:.:..|.|
  Fly  1769 EE------------NSKAIEEDKSSTVLTADHAK-EPETVLEKMEVDEKANDDQSAVSKAEGSDE 1820

Human   227 ESTESTDSQKRRSGRQVKRRKYNEDLDFKVVDDDGETIAVLGAGRTSALSASTLAWQAEEPPEDD 291
            :||:.::.:      :....|..|.|:.     :||                      :|..::.
  Fly  1821 KSTDDSNPE------EATTEKNKESLEI-----EGE----------------------KERVKEG 1852

Human   292 ANIIEKILASKTVQEV-HPGEPPF-DLELFYVKYRNFSYLHCKWATMEELEK-DPRIAQKIKRFR 353
            ...::|....||..:: :..||.| |:|.::|||||||||||:|.|.|||.| |.|:|.||:||:
  Fly  1853 EESVKKENDEKTEADMENKPEPVFIDVEEYFVKYRNFSYLHCEWRTEEELLKGDRRVAAKIRRFQ 1917

Human   354 NKQAQMKHIFTEPDEDLFNPDYVEVDRILEVAHTKDAETGEEVTHYLVKWCSLPYEESTWELEED 418
            .||:|..:||...:::.||.|:.||||:|:::...|..:||...||||||.|||||:.|||||||
  Fly  1918 QKQSQQLNIFENIEDEPFNQDFTEVDRVLDMSVHTDETSGETTKHYLVKWKSLPYEDCTWELEED 1982

Human   419 VDPAKVKEFESLQVLP---EIKHVERPASDSWQKLEKSREYKNSNQLREYQLEGMNWLLFNWYNR 480
            ||..|::::.....:|   |.|..:||..:.|:||||:..||..|.||.|||||:|||.|:|||.
  Fly  1983 VDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKLEKTPVYKGGNSLRPYQLEGLNWLKFSWYNT 2047

Human   481 KNCILADEMGLGKTIQSITFLSEIFLRGIHGPFLIIAPLSTITNWEREFRTWTEMNAIVYHGSQI 545
            .||||||||||||||||:||:..::..||.||||:|||||||.||:|||..||:||.:|||||..
  Fly  2048 HNCILADEMGLGKTIQSLTFVHSVYEYGIRGPFLVIAPLSTIPNWQREFEGWTDMNVVVYHGSVT 2112

Human   546 SRQMIQQYEMVYRDAQGNPLSGVFKFHVVITTFEMILADCPELKKIHWSCVIIDEAHRLKNRNCK 610
            |:||||.||..|:...|..|....||:|:|||||||:.|..:||..:|...:|||||||||||||
  Fly  2113 SKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEMIVTDYMDLKAFNWRLCVIDEAHRLKNRNCK 2177

Human   611 LLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETAFLEEFGDLKTEEQVKKLQSI 675
            |||||:.:.|||:|||:||||||::.||||||||||||||.|:..|:.|||.|:|||:|.|||::
  Fly  2178 LLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFLEPSQFSSQEEFMSEFGSLRTEEEVNKLQAL 2242

Human   676 LKPMMLRRLKDDVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFSFLTKGANQHNMPNLINTMM 740
            |||||||||||||||:||||:|||||||||||||||||.|||:|||||.||....|:|||:||||
  Fly  2243 LKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKKYYRGILEQNFSFLKKGTTSANIPNLMNTMM 2307

Human   741 ELRKCCNHPYLINGAEEKILEDFRKTHSPDAPDFQLQAMIQAAGKLVLIDKLLPKLIAGGHKVLI 805
            ||||||.||||:|||||:|..||:..|..| |:...:.:|.:|||:||||||||||.|.||:|||
  Fly  2308 ELRKCCIHPYLLNGAEEQIQYDFKSQHGED-PESYYKNLILSAGKMVLIDKLLPKLKANGHRVLI 2371

Human   806 FSQMVRCLDILEDYLIQRRYTYERIDGRVRGNLRQAAIDRFCKPDSDRFVFLLCTRAGGLGINLT 870
            |||||||||||||||:.|:|.:||||||:||||||.||||:.||.||||||||||:|||||||||
  Fly  2372 FSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQEAIDRYSKPGSDRFVFLLCTKAGGLGINLT 2436

Human   871 AADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVLQD 935
            ||||.||:|||||||||||||||||||||.|.||:|||:.||:||||||||||:||||||||||.
  Fly  2437 AADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKIYRLLCRNTYEREMFDKASMKLGLDKAVLQS 2501

Human   936 INRKGGTNG-VQQLSKMEVEDLLRKGAYGALMDEEDEGSKFCEEDIDQILQRRTHTITIQSEGKG 999
            :|.:|..:| .:||||.|:||||:||||||:||:::.|.||||||||.||:|||..||::|| ||
  Fly  2502 MNTQGSKDGNNKQLSKKEIEDLLKKGAYGAVMDDDNAGDKFCEEDIDSILKRRTQVITMESE-KG 2565

Human  1000 STFAKASFVASGNRTDISLDDPNFWQKWAKIAELDTEA--KNEKESLVIDRPRVRKQTKHYNSFE 1062
            |||:||||.|||||:||::|||:||.||||..::|.:|  ::|.|.||:..||.|.|.|.|.
  Fly  2566 STFSKASFAASGNRSDITIDDPDFWTKWAKKVDIDPDACERDETEDLVLSEPRRRTQIKRYG--- 2627

Human  1063 EDELMEFSELDS---DSDE------RPTRSRRLNDKAR--------------------------- 1091
            .:::||.:..:|   :|||      |..|.:...|:||
  Fly  2628 HEDVMELNSEESSNENSDEEGGIGLRSRRRKEKRDRAREKKGNDEYIPRERDALAALGLEEIQYG 2692

Human  1092 RYLRAECFRVEKNLLIFGWGRWKDILTHGRFKWHLNEKDMEMICRALLVYCVKHYKGDEKIKSFI 1156
            .:.::|||:|||.||.||||||.::|..|:||....:.|:|...|.:|:||::.||||||||:||
  Fly  2693 NWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGWRDVDVEDCARIILLYCLQVYKGDEKIKTFI 2757

Human  1157 WELITPTKDGQAQTL-QNHSGLSAPVPRGRKGKKT---------------------------KNQ 1193
            |:|||||:||:.|.: ::||||...|||||.|.|:                           |:.
  Fly  2758 WDLITPTEDGEVQKISRDHSGLHNLVPRGRNGGKSNKESTGVSTPAPGSASGSNSGNTTPAHKSS 2822

Human  1194 LLIPELKDADWL---ATCNPEVVLHD-----------------DGYKKHLKQHCNKVLLRVRMLY 1238
            .|....||:..:   |.......:||                 ..|||||.:|.|||||||||||
  Fly  2823 ALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEKYDADAYLEGAYKKHLGRHANKVLLRVRMLY 2887

Human  1239 YLKAEILGEAAEKAFEGSPARELDV---PLPDIDYMEIPVDWWDAE-ADKSLLIGVFKHGYERYN 1299
            |::.|::|:..::..:.:|..||.:   |.||    ::|..||:.. .|||||:|.:|||.|.|.
  Fly  2888 YIQHEVIGDFVQQIKDNTPISELPIRPPPTPD----QVPSSWWNPICCDKSLLVGTYKHGCEMYR 2948

Human  1300 AMRADPALCFLEKVG------------MP---DEKSLSAEQG---VTDGTSDI------------ 1334
            .|||||.|||:..||            :|   |:.:...:.|   ..|||:..
  Fly  2949 QMRADPNLCFVTHVGAGAAGDDLAVTSLPINEDDANSKHDDGDEVDDDGTTTTKDSDSTKLTGGD 3013

Human  1335 -------PERGNTDKEDNAEDKVDGLQKQTESSSDG----------------------------- 1363
                   |||.::..:.::|:...|..| |||.:|.
  Fly  3014 NKDSLLDPERPSSSGKSSSENASGGNDK-TESENDATTVSESSYKSEVLPGKGSDLDVSVAQQDA 3077

Human  1364 -------------------------------------------------GDG----VFSEKKDD- 1374
                                                             ||.    :.|||||:
  Fly  3078 LSATPELANTSDPKMNKNDAQVSASVSCDPADSSSPEAAGKAQGTGVQTGDAGELDIESEKKDNE 3142

Human  1375 -------------------------------------------------------------SRAA 1378
                                                                         |:||
  Fly  3143 KETKESTGDAPAVEAKKDSAAIARAEGDKTESCTNNATTNISTTTTTTTITNTTTTTNNPSSKAA 3207

Human  1379 QD-------------GSDPDKS-----------------PWPVSSALTARLRRLVTVYQRCNRKE 1413
            ..             |.|.::|                 .||....|..||||::|.|||..:||
  Fly  3208 NSNNTTDHANSNSHLGLDEEESVAGSYPPTVAAVEDATTMWPSMQDLNTRLRRVITAYQRNYKKE 3272

Human  1414 LCR----------------------PEI------------------------------------- 1419
            ..:                      |.:
  Fly  3273 ELKLQQKAKLQALVSSTPPLSVPTTPTLQSMQMQLQSGSGSGGSGIGSSAQHDASGRSLQALMQS 3337

Human  1420 -------------------------LGPGNQG--------------------------------- 1426
                                     :|.|..|
  Fly  3338 QGASTSAAAAAAASSAGGSCSGSGQVGMGGAGVMPAMPTAADISLMLSILNTTDVNQLANLDINK 3402

Human  1427 ---YWV-QEEMFRRTSEMDLINKEAQ--------KRWTRREQADFYRTVSSFGVVYDQEKKT--- 1476
               |.| ......|..:|:|..||.:        |:|.|||:.:|.|.::.:||  |....|
  Fly  3403 LAMYLVSMNNKMERQGKMELAAKERESQRLQLIPKKWNRREEYEFLRVLTGYGV--DLHVSTPMA 3465

Human  1477 --------FDWTQFRIISRLDKKSDESLEQYFYSFVAMCRNVCRLPTWK-----DGGPPDTTIYV 1528
                    .|||:|:.::.|::||||:|..|:..|||||:....|...:     :|       .:
  Fly  3466 SSNGSSLSPDWTKFKQMAHLERKSDETLTDYYKVFVAMCKRQAGLKLSESERGLEG-------II 3523

Human  1529 EPITEERAARTLYRIELLRKVREQVLKCPQLHERLQLCRPSLYLPVWWECGKHDRDLLIGTAKHG 1593
            |.|.:|.|...|.|:|:|.|:|| |.:.|.|.|||:||..:...|.|||.|:||::|:....|||
  Fly  3524 EEIEKEHAKLILDRLEVLAKLRE-VARNPMLEERLKLCTKNADTPDWWEPGRHDKELITAVLKHG 3587

Human  1594 LNRTDCYIMNDPQLSFLDAYRNYAQHKRSGTQAPGNLCCLYQTNSKLYESLTYSQMSRTSE---- 1654
            |.|::.:|.|||..||.::.:.:.:...:..|   ....|...|::..|.|..::....:|
  Fly  3588 LYRSETFIFNDPNFSFGESEKRFIRELEAQIQ---RTIKLEAFNAEKAEKLAAAEKDAATEKAAA 3649

Human  1655 ----------SLENEPENLVRVESRDDHLSLPDVTCENFISKVQDVISI-----------NHD-- 1696
                      |::||..:|      ||.|    :|.|:.|.|...|..|           .||
  Fly  3650 TEKAAAEKAASVKNEVIDL------DDEL----MTNESVIKKESPVTPIKEEIKSEESPEKHDTA 3704

Human  1697 -------------------ESLLPESLESMMYGKKVLSQEPSSFQESPSTNT-----------ES 1731
                               |...||:.|     |:.|.:..:..::..||.|           |.
  Fly  3705 DNLEDKNSDAEESTKIKGKEDFNPETTE-----KEALDESTNLNKDKSSTETLVPEIEDSKPSED 3764

Human  1732 RKDVITISISKDGNCQSGGPE-----------AEIASGPTF----MGSLEAGGVAQANIKNGKHL 1781
            :.:|..:.::::|. :.|.||           .|..|.|..    :..:||...|....:|
  Fly  3765 KMEVEELPVAENGE-KEGSPEKCSDAEDKKFSEEKPSSPAVPDGKVSEMEADEAAPNTEEN---- 3824

Human  1782 LMSISKEGELCCSEAGQRPENIGQLEAKCLASPSLNPGNESGFVDMCSLSVCDSKRNLSSDQQLI 1846
                       ||...:.||.  :.|.|.:.......|.             :|.......::..
  Fly  3825 -----------CSGDSESPEK--ECEDKVVEKVEEEKGE-------------NSYEKAEEQKEET 3863

Human  1847 DLLENKSLESKLILSQNHSDEEEEEEENEEENLAMAVGMGERPEVLHL----TEPTTN-ISREKN 1906
            :.||..|:||:        ..|:.|...|.|........|:: ::|.|    ::|..: :.:||.
  Fly  3864 EKLEKSSIESE--------PSEKSETVLEPEVAVPKKSTGDQ-DILDLVAGPSDPDDDEVMKEKE 3919

Human  1907 QGFQDETKKGSLEVANQTPGLQRAFPA---------PAACQCHCKHMERWMHGLENDEFEIEKPK 1962
            :..::|.||.:.|:..:.|.|:...||         |....|    |.||.     .:|.:|:..
  Fly  3920 KAVEEECKKQAAELKARFPDLEVIQPATVKQQKLEKPKLEMC----MIRWF-----KDFALERRI 3975

Human  1963 AYIPDLFK-------SKTNTIAMEGEPTAIPSQPFKVK-HELLKEPWKESAEGQNVFP------- 2012
            |:|....:       ||.:..|     |...:....:. ||.:  |...|.|.::..|
  Fly  3976 AHIVACVESGNWPVDSKYSAFA-----TCKGATDLSIALHESI--PHLSSLERRSTTPDVITITT 4033

Human  2013 ----TYPLEGSELKSEDMDFENKDDYDRDGNCHSQDYPGKYSEEESKSSTSGITGDIGDELQEAR 2073
                |..|:.|                     |.|...   |...:.|::||
  Fly  4034 DQGVTKHLQTS---------------------HMQQVA---SSASAASTSSG------------- 4061

Human  2074 APTIAQLLQEKTLYSFSEWPKDRVIINR--LDNICHVVLKGKWPSSQQYEPSGTLPTPVLTSSAG 2136
               :.|:.|.|...|.|....|...||.  ...:......|...|.....|..:| :....||||
  Fly  4062 ---VPQVTQSKPSSSNSLPGLDAKSINAAVAAAVAAAAAGGNATSLSSLLPGMSL-SAATGSSAG 4122

Human  2137 SRTSLSEPEAA--------EHSFSNGAALAAQIH---KESFLAPVFTKDEQKHRRPYEFEVERDA 2190
            ..:.||.|.|.        .|...:.....|::|   ..|.:||   ||.:......|.......
  Fly  4123 GVSGLSVPSAGSGVGKKRKRHIAIDVETERAKLHALLNSSTMAP---KDWESEIANMEALSGSSG 4184

Human  2191 KARGLEQFSATHGHTPIILNGWHGESAMDLSCSSEGS-----------PGATSPFPVSASTPKIG 2244
            :.|| ...||:.|..|   ...|..:::....|.:.|           |...:|..:|:|.||:.
  Fly  4185 RGRG-GNSSASSGMQP---PPAHQHASLSRQSSGQFSKPAVPAMKTPPPSMGAPMDLSSSLPKMN 4245

Human  2245 AISSLQGAL---GMDLSGILQAGLIHPVTGQIVNGSL-----------RRDDAATR--------- 2286
            ....|:.|.   .:|||.:....:  |.....|:.:|           :.||...:
  Fly  4246 MTEMLKSASSSGAIDLSEVQDFSM--PSKKSSVHAALSSAFPSMGNKSKLDDTLNKLMKKNNCTI 4308

Human  2287 ------RRRGRRKHVEGGMDLIFLKEQ-------------------------TLQAG-------- 2312
                  :.:.|:|..|..:.|...|||                         .||:.
  Fly  4309 EEPVIGKEKKRKKLDEIVLGLSAAKEQKTFPDPSLPSSKKPQIPPSVSVTPANLQSSSNQQSNQK 4373

Human  2313 --ILEVHEDPGQA-TLSTTHPEGPGPATSAP------EPATAASSQAEKSIPSKSLLD------- 2361
              .:.|...||:: :.|:....|.|.::||.      ...:|..:.|...:.||..|:
  Fly  4374 PFTITVTTVPGKSKSGSSNSGSGTGGSSSASGGGAGGSGLSALQNMAMGGLSSKDSLNALLAQTM 4438

Human  2362 ------WLRQQ------------------------------------------------------ 2366
                  :|:||
  Fly  4439 ATDPQTFLKQQQKMMQFLPPAQRKAYENMLAEMEQAMKISSKFSTNSPHDVKVNKWLSDMTSPLG 4503

Human  2367 ----ADYSLEVPGFGANFSDKPKQRRPRCKEPGKLDVSS-------------------------- 2401
                .||   |.|.||:.|.....||.. ::.|....||
  Fly  4504 DQLSIDY---VGGGGASGSGSGNSRRSN-RQQGNSQQSSSAAQLQKQQQQQQQQQQQQQQHSMPG 4564

Human  2402 ---LSGEERVPAIPKEPG-------------LRGFLPEN-----------KFNHTLAEPILR--- 2436
               |:|||.||.|.|:.|             |..:|.||           :..:.::.|..|
  Fly  4565 PQNLTGEEPVPVINKQTGKRLGGNKAPQLKRLMQWLTENPNYEVDPKWLEQMQNPMSTPSPRPAS 4629

Human  2437 ------DTGPRRRGRRPRSEL--------LKAPSIVADSPSG--MGPLFMN-----GLIAGMDLV 2480
                  .:..:..|.||.|.|        .:..|..|.|.:|  .|....|     ...|.:|..
  Fly  4630 MESGYGSSAVKSHGGRPLSNLSSTSSSSHTQQQSSAAQSQAGGNSGSSKKNSRQQTAASAALDQA 4694

Human  2481 GLQ----------NMRNMPGI----PLTGLVGFPAGFATMPTGEEVKSTLSMLPMMLPGMAAVP- 2530
            .||          .:.|:||:    |...|..|          :.....|||....:|||..:|
  Fly  4695 ALQFGSLAGLNPSLLANLPGLGAFDPKNPLAAF----------DPKNPLLSMSFGGMPGMGNIPG 4749

Human  2531 -----------QMFGVGGL----------LSPPMAT----------------TCTSTAPASLSST 2558
                       .:.|:|||          |:..||.                :..|.|.:..|:|
  Fly  4750 LGNLNNMNLFASLAGMGGLGNLAGMDTQSLAALMAAAGPTLGGLTGASGGAGSGKSQAQSQSSAT 4814

Human  2559 TKSGTAVTEKTAEDKPSSHDVKTDTLA--EDKPGPGPFSDQSEPAITTSSPVAFNPFLIPGVSPG 2621
            :.|.:|..:|..:.:..:.:......|  ....|....|.....|.:.|...|..|||.|  :|.
  Fly  4815 SSSSSASKKKQQQQQQQAQNEAAQLAAAISASTGGSGASGGKNAAASASQLAAGFPFLFP--NPS 4877

Human  2622 LIYPSMFL---------SPGMGMALPAMQQARHSEIVGLESQKRKKKKTKGDNPNSHPEPAPSCE 2677
            |:||.|.|         |.|:|.|...:.| :::.:.|..|.......|:..:..|..:.:.|
  Fly  4878 LLYPPMGLGGLNPYSLGSSGLGSAYDQLAQ-QYNLLNGATSSASNTSSTQSKSHQSQSKSSQS-- 4939

Human  2678 REPSGDENCAEPSAPLPAEREHGAQ-----------AGEGALKDSNNDT 2715
            |..:...|.|.......|....||.           :|.|....|.|.:
  Fly  4940 RNTTASANSAASLMNAMASMGGGASTVTTPSTSASGSGRGRQSSSRNQS 4988

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHD6	XP_016883588.1	PTZ00449	<105..374	CDD:185628	82/292 (28%)
		CD1_tandem_CHD5-9_like	289..354	CDD:349315	32/67 (48%)
		CD2_tandem_CHD5-9_like	373..431	CDD:349310	30/57 (53%)
		PLN03142	461..>986	CDD:215601	375/525 (71%)
		DEXHc_CHD6	462..683	CDD:350816	146/220 (66%)
		PHA03247	<2320..2694	CDD:223021	113/591 (19%)
		BRK	2403..2438	CDD:470653	14/67 (21%)
kis	NP_001137761.1	Atrophin-1	221..>533	CDD:460830
		Med15	<1056..>1265	CDD:312941
		PRK12678	1319..>1500	CDD:237171
		PTZ00121	<1419..1923	CDD:173412	100/394 (25%)
		CD1_tandem_CHD5-9_like	1851..1918	CDD:349315	32/66 (48%)
		CD2_tandem_CHD5-9_like	1937..1995	CDD:349310	30/57 (53%)
		PLN03142	2029..>2606	CDD:215601	409/578 (71%)
		PTZ00341	<3662..3887	CDD:173534	52/278 (19%)
		BRK	4568..4611	CDD:462196	13/42 (31%)