DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNRF3 and znrf3

DIOPT Version :9

Sequence 1:	NP_001193927.1	Gene:	ZNRF3 / 84133	HGNCID:	18126	Length:	936	Species:	Homo sapiens
Sequence 2:	NP_001072864.1	Gene:	znrf3 / 780325	XenbaseID:	XB-GENE-5937936	Length:	853	Species:	Xenopus tropicalis

Alignment Length:	902	Identity:	545/902 - (60%)
Similarity:	611/902 - (67%)	Gaps:	128/902 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    37 LPLLLGLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGATLSAEGEIVQM 101
            |||:...:|.|..||.:.||||||||||||||||:|||.|:||.|.|||||||||:|||||||||
Frog    10 LPLVWLWVLLAVAPGESLAKETAFVEVVLFESSPNGDYKTHTTELQGRFSRAGATISAEGEIVQM 74

Human   102 HPLGLCNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAID 166
            |||||||||||||||||||||||||||||:||||||||||||||||||||||||||||:||:|::
Frog    75 HPLGLCNNNDEEDLYEYGWVGVVKLEQPEMDPKPCLTVLGKAKRAVQRGATAVIFDVSDNPDAVE 139

Human   167 QLNQGSEDPLKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDMGIFLAFFVVVSL 231
            |||||.||||||||||:||.|||||||||||||.|||||||||||||||||||||||||||||||
Frog   140 QLNQGLEDPLKRPVVYMKGMDAIKLMNIVNKQKGARARIQHRPPRQPTEYFDMGIFLAFFVVVSL 204

Human   232 VCLILLVKIKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAIC 296
            ||||||:|||||||||||||||:|||||||||||||.:|.|..||||||.|||||||||||||||
Frog   205 VCLILLIKIKLKQRRSQNSMNRMAVQALEKMETRKFKAKGKVPREGSCGGLDTLSSSSTSDCAIC 269

Human   297 LEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQ-KGNPSAVCVETSNLSRGR-- 358
            ||||||||||||||||||||::||||||||:||||||||||||| ||....||||.|: :|||
Frog   270 LEKYIDGEELRVIPCTHRFHKRCVDPWLLQNHTCPHCRHNIIEQKKGGHGPVCVENSS-NRGRQQ 333

Human   359 -QQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPL 422
             ||||.|||||||||.||..|.||||||||..||||:|:||::|..|..||..:||.::..|.|:
Frog   334 QQQRVILPVHYPGRVQRTGPIAAYPTRTSMGPHGNPITVLTVERPLEPDLYPARTPTFLAGYRPV 398

Human   423 HLDHSLAAHRCGLEHRAY--SPA-HPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQE- 483
            .|||:.:.|.|.|||..|  .|| |.|||.|.|||.|:...|:||||||||||||||||||.|:
Frog   399 SLDHASSGHHCDLEHPPYPAPPAGHGFRRAKYSGRGFNNGTCYSQYETMYQHYYFQGLSYPHQQE 463

Human   484 --GQSPPSLAPRGPARAFPPSGSGSLL--FPTVVHVAPPSHLESGSTSSFSCY----HGHRSVCS 540
              |...|.:...|...:| .||:..|.  .||::|:||||       |..|||    |.||||||
Frog   464 VGGSQAPRVVENGHNHSF-HSGNNMLYQPAPTLMHMAPPS-------SVGSCYLHSQHQHRSVCS 520

Human   541 GYLADCPGSDSSSSS--SSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRS 603
            |||||.|.|||||||  ||.|.|.|||||::||||.|||||||||||||||||||:||::|||||
Frog   521 GYLADVPCSDSSSSSSASSAQGHASSSDSMLDCTEASNQGVYGSCSTFRSSLSSDFDPYVYRSRS 585

Human   604 PCR-----ASEAGGSG--SSGRGPALCFEGSPPPEELPAVHSHGAGRGEPWPGPASPSGDQVSTC 661
            |.|     |...||.|  .||||...|             .||..       .|.|||.|::|:|
Frog   586 PARTGGGDAPGCGGEGGTGSGRGRVEC-------------RSHQT-------FPNSPSRDRLSSC 630

Human   662 SLEMNYSSNSSLEHRG---PNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCACCCEPQPSPAG- 722
            |:|||||||||||.||   .:.:..:..:..|.|...|.|...||      |.||.:.|   ||
Frog   631 SMEMNYSSNSSLERRGAVISSGTVPDASVSISQGGGKDRRGPEKG------CTCCFQRQ---AGD 686

Human   723 PSAGAAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDG---VKYEGLPCCFYEE 784
            ||:..   :.|:|||..::.|||:       ||.|||.:....|.|||.   :.:...|||.|||
Frog   687 PSSDC---TNLYLGPDPHQTSGPS-------SSGGLYSVTSSILHRTDPGTVLGHPSRPCCLYEE 741

Human   785 KQVARGGGGGSGCYTEDYSVSVQYTLTEEPP-------PGCYPGARDLSQRIPIIPEDVDCDLGL 842
            ..       || ||.|||:||:||.|.|...       .||..|     |.|||||||...|.||
Frog   742 NH-------GS-CYNEDYAVSIQYALAEAAAAAAAAAVAGCEAG-----QPIPIIPEDPGYDGGL 793

Human   843 PSDCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERALCCQ----------ARALLR 889
              :|.| |.  ||             .:....|||..|.||          .|||.|
Frog   794 --ECVG-HV--SW-------------EMEGEEEEEEVLYCQEGPCCALAEETRALCR 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNRF3	NP_001193927.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		zf-RING_2	293..334	CDD:290367	37/40 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	608..693		32/89 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..758		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	849..875		3/25 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	892..936
znrf3	NP_001072864.1	ZNRF_3_ecto	74..180	CDD:375639	96/105 (91%)
		RING-H2_ZNRF3	266..309	CDD:319713	39/42 (93%)
		RING-H2 finger (C3H2C3-type)	266..306	CDD:319713	36/39 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	583..629		21/65 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	650..673		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..713		13/37 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..853
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	415	1.000	Domainoid score	I5566
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H46592
Inparanoid	1	1.050	946	1.000	Inparanoid score	I3409
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40703
OrthoDB	1	1.010	-	-		D114304at7742
OrthoFinder	1	1.000	-	-		FOG0013402
OrthoInspector	1	1.000	-	-		oto150236
Panther	1	1.100	-	-	LDO	PTHR16200
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R768
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110