Protein Alignment ZNRF3 and Znrf3

DIOPT Version :9

• Sequence 1: NP_001193927.1
• Gene: ZNRF3 / 84133
• HGNCID: 18126
• Length: 936
• Species: Homo sapiens
• Sequence 2: XP_038948772.1
• Gene: Znrf3 / 685487
• RGDID: 1593771
• Length: 913
• Species: Rattus norvegicus
• Alignment Length: 924
• Identity: 793/924 - (85%)
• Similarity: 817/924 - (88%)
• Gaps: 23/924 - (2%)

Human     1 MRPRSGGRPGATGRRRRRLRRRPRGLRCSRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVL 65
            |||||||||||.|||||||||.|||   .||||||||||||||||||||||||||||||||||||
  Rat     1 MRPRSGGRPGAPGRRRRRLRRGPRG---RRLPPPPPLPLLLGLLLAAAGPGAARAKETAFVEVVL 62

Human    66 FESSPSGDYTTYTTGLTGRFSRAGATLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPE 130
            |||||||||||:|||||||||||||.|||||||||||||||||||||||||||||||||||||||
  Rat    63 FESSPSGDYTTHTTGLTGRFSRAGAMLSAEGEIVQMHPLGLCNNNDEEDLYEYGWVGVVKLEQPE 127

Human   131 LDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAIKLMNIV 195
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||
  Rat   128 LDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPVVYVKGADAVKLMNIV 192

Human   196 NKQKVARARIQHRPPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALE 260
            ||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   193 NKQKVARARIQHLPPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQRRSQNSMNRLAVQALE 257

Human   261 KMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLL 325
            |||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||
  Rat   258 KMETRKFNSKSKGRREGSCGALDTLSSGSTSDCAICLEKYIDGEELRVIPCTHRFHRKCVDPWLL 322

Human   326 QHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHRTNAIPAYPTRTSMDSH 390
            |||||||||||||||||||.|||||||||:|||..||||||||||||||||||||||||||||||
  Rat   323 QHHTCPHCRHNIIEQKGNPGAVCVETSNLTRGRHPRVTLPVHYPGRVHRTNAIPAYPTRTSMDSH 387

Human   391 GNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHRAYSPAHPFRRPKLSGRS 455
            |||||||||||||||:|||||||.|:|.||||||||:||.|||.||||||||||||||||.|.||
  Rat   388 GNPVTLLTMDRHGEQNLYSPQTPTYVRGYPPLHLDHTLAPHRCSLEHRAYSPAHPFRRPKFSSRS 452

Human   456 FSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSH 520
            ||||||||||||||||||||||||||||.|..||:.|||.:|||||||..||||||:||:|||:|
  Rat   453 FSKAACFSQYETMYQHYYFQGLSYPEQESQPVPSVTPRGQSRAFPPSGGSSLLFPTMVHMAPPAH 517

Human   521 LESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCST 585
            :||||||||||||||||||||||||||||| |||:|||||.||||||||||||||||||||||||
  Rat   518 VESGSTSSFSCYHGHRSVCSGYLADCPGSD-SSSNSSGQCRCSSSDSVVDCTEVSNQGVYGSCST 581

Human   586 FRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPPPEELPAVHSHGAGRGEPWPGP 650
            ||||||||||||||||                ||||:..|||||||||||.|:.||||||||.||
  Rat   582 FRSSLSSDYDPFIYRS----------------RGPAVHLEGSPPPEELPAAHNQGAGRGEPWLGP 630

Human   651 ASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAAPDLRRTWKGGHELPSCACCCE 715
            |||||||:||||||||||||||||.|||||||||||||.|||||.|||||||||.|.||||||.|
  Rat   631 ASPSGDQLSTCSLEMNYSSNSSLEPRGPNSSTSEVGLEVSPGAALDLRRTWKGGPEGPSCACCFE 695

Human   716 PQPSPAGPSAG-AAGSSTLFLGPHLYEGSGPAGGEPQSGSSQGLYGLHPDHLPRTDGVKYEGLPC 779
            |||...|...| .||.|:|||||.|.|...||.||||.||||||||||.||.|||||||||||||
  Rat   696 PQPVTLGSGIGTTAGGSSLFLGPRLLEDCNPASGEPQLGSSQGLYGLHSDHYPRTDGVKYEGLPC 760

Human   780 CFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPPPGCYPGARDLSQRIPIIPEDVDCDLGLPS 844
            |||||||||...|.|:|||||||||||||||||||||.||.|||||||||||||||||||||||.
  Rat   761 CFYEEKQVAHSAGRGNGCYTEDYSVSVQYTLTEEPPPSCYAGARDLSQRIPIIPEDVDCDLGLPQ 825

Human   845 DCQGTHSLGSWGGTRGPDTPRPHRGLGATREEERALCCQARALLRPGCPPEEAGAVRANFPSALQ 909
            ||||.||...|||..|.|.||....||.||:||:|.|.||.  ::|||.||||.|.||:..||.|
  Rat   826 DCQGRHSHSPWGGALGLDGPRLQWSLGTTRKEEQAPCYQAE--VQPGCSPEEADASRASLSSAPQ 888

Human   910 DTQESSTTATEAAG 923
            |||||...|.||:|
  Rat   889 DTQESLALAAEASG 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZNRF3	NP_001193927.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		23/29 (79%)
		zf-RING_2	293..334	CDD:290367	40/40 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	608..693		64/84 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	739..758		12/18 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	849..875		12/25 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	892..936		20/32 (63%)
Znrf3	XP_038948772.1	ZNRF_3_ecto	98..204	CDD:408039	104/105 (99%)
		RING-H2_ZNRF3	289..333	CDD:319713	43/43 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H46592
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114304at7742
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.510