DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNRF3 and mura

DIOPT Version :9

Sequence 1:	NP_001193927.1	Gene:	ZNRF3 / 84133	HGNCID:	18126	Length:	936	Species:	Homo sapiens
Sequence 2:	NP_731367.2	Gene:	mura / 41145	FlyBaseID:	FBgn0037705	Length:	1173	Species:	Drosophila melanogaster

Alignment Length:	122	Identity:	33/122 - (27%)
Similarity:	55/122 - (45%)	Gaps:	20/122 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   240 IKLKQRRSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGE 304
            :.|.:|..:.....|....::::.:.|||.:              :.:...|.|.:|:..:...:
  Fly  1038 LSLAERLGEAKPRGLTRNEIDQLPSYKFNPE--------------VHNGDQSSCVVCMCDFELRQ 1088

Human   305 ELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNI------IEQKGNPSAVCVETSNLS 355
            .|||:||:|.||.||||.||..:.|||.||.|.      ::|:....|.....:.||
  Fly  1089 LLRVLPCSHEFHAKCVDKWLRSNRTCPICRGNASDYFDGVDQQQQSQATAGAAAALS 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNRF3	NP_001193927.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		zf-RING_2	293..334	CDD:290367	19/40 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	608..693
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..758
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	849..875
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	892..936
mura	NP_731367.2	zf-RING_2	1076..1118	CDD:290367	19/41 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R768
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950