DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNRF3 and Rnf43

DIOPT Version :9

Sequence 1:	NP_001193927.1	Gene:	ZNRF3 / 84133	HGNCID:	18126	Length:	936	Species:	Homo sapiens
Sequence 2:	XP_006247152.1	Gene:	Rnf43 / 303412	RGDID:	1305204	Length:	802	Species:	Rattus norvegicus

Alignment Length:	940	Identity:	283/940 - (30%)
Similarity:	389/940 - (41%)	Gaps:	278/940 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    42 GLLLAAAGPGAARAKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGATLSAEGEIVQMHPLGL 106
            ||:||||......|::.|.:.|:..:..|:|   .....|.|.|:.......|||:::|.|||.|
  Rat    29 GLVLAAAVESERSAEQKAIIRVIPLKMDPTG---KLNLTLEGVFAGVAEVSPAEGKLMQSHPLYL 90

Human   107 CNNNDEEDLYEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQG 171
            ||.:|:::| |.|::.:||||.|...|:|||::..||:.|.:|||:||:||::|:..|.:||.|
  Rat    91 CNASDDDNL-EPGFISIVKLESPRRAPRPCLSLASKARMAGERGASAVLFDITEDRSAAEQLQQ- 153

Human   172 SEDP--LKRPVVYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDMGIFLAFFVVVSLVCL 234
               |  |.:|||.:.|:||.|||..|.|.:.|...|:.:.|.....| |:.|.|.....|.::.|
  Rat   154 ---PLGLTKPVVLIWGSDAEKLMEFVYKNRKAYVWIELKEPPAWANY-DVWILLTVVGTVFVIIL 214

Human   235 ILLVKIKLKQRRSQ-NSMNRLAVQALEKMETRKFNSKSKGRR-----EGSCGALDTLSSSSTSDC 293
            ..:::|:.:...|: :.:.:...:|:.::.||::.:..:..|     .||       ||||...|
  Rat   215 ASVLRIRCRPHPSRPDPLQQRTARAISQLATRRYQASCRRARAEWPDSGS-------SSSSAPVC 272

Human   294 AICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAVCVETSNLSRGR 358
            |||||::.:|:|||||.|.|.|||.||||||.||.|||.|..||:|......|:....|....||
  Rat   273 AICLEEFTEGQELRVISCLHEFHRTCVDPWLHQHRTCPLCMFNIVEGDSFSQALGASPSYQEPGR 337

Human   359 QQRVTLPVHYPGRVHRTNAIP-AY---PTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSY 419
              |:.|...:||..|  ..:| ||   |:|.|:.....|               .|..|:...|.
  Rat   338 --RLHLIRQHPGHAH--YHLPSAYLLGPSRNSVAQTPRP---------------RPFLPSQEPSM 383

Human   420 PPLHLDHSLAAHRCGLE---HRAYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPE 481
            ...|.....|:|....|   |.|.||.||:.:    |...::..|.||:
  Rat   384 GSRHQRLPRASHLRAPEEQQHLAVSPGHPYAQ----GWGPNRLRCTSQH---------------- 428

Human   482 QEGQSPPSLAPRGPARAFPPSGSGSLLFPTVVHVAPPSHLESGSTSSFSCYHGHRSVC---SGYL 543
                  |:..|....||.|                   |..|||..|:         |   ||||
  Rat   429 ------PNACPVALRRARP-------------------HESSGSGESY---------CTERSGYL 459

Human   544 ADCPGSDSSSSSSSGQCHCSSSDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRAS 608
            ||.|.||    ||||.||.|||||||:||::|.|||:||.||||||||||:||.:|.|
  Rat   460 ADGPASD----SSSGPCHGSSSDSVVNCTDISLQGVHGSSSTFRSSLSSDFDPLVYCS------- 513

Human   609 EAGGSGSSGRGPALCFEGSPPPEELPAVHSHGAGRGEPWPGPAS-----PSGD-QVSTCSLEMNY 667
                       |....:|.   |..|::.|.          |.|     |:|: |||:   .::|
  Rat   514 -----------PEGALQGK---EVQPSMTSR----------PRSLDSVVPTGETQVSS---HIHY 551

Human   668 ---------------SSNSSLEHRGPNS--STSEVGLEASPGAAPDLRRTWKGGHELPSCACCCE 715
                           |....||...|.|  :.|...||.|   .||.:.|      .|:.| ...
  Rat   552 HRHRHHHYKKQFQWHSRKPGLETGVPQSRPAASHTQLEPS---LPDQQLT------TPNPA-VSS 606

Human   716 PQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGG-----EPQSGSSQGLYGLHPDHLPRTDGVKYE 775
            ..|:|..|.|             |.|   ||.|     .|....:..|..|...:||    |:|
  Rat   607 MLPNPQRPRA-------------LTE---PAPGLAEAVSPSPSPNPSLLNLQKSNLP----VRY- 650

Human   776 GLPCCFYEEKQVARGGGGGSGCYTED---------------YSVSVQYTLTEE------PPPG-- 817
                     .|..|.||......|..               ||.|:.|....|      .|||
  Rat   651 ---------PQRKRRGGPSEALPTSQPQDLTVHTACPVPPHYSPSLAYPWPPEVHPLIFRPPGLD 706

Human   818 ----------CYPGARD----LSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHR 868
                      ||..::.    |:.|.|:.|    |   ||.:   .||..|:      |||...|
  Rat   707 RRLLHDVPGPCYSSSQPVWLYLNPRQPLGP----C---LPGE---GHSKWSF------DTPEDRR 755

Human   869 GLGATREEERALCCQARALLRPGCPPEEAG 898
                        |..:...:.|..|.|.:|
  Rat   756 ------------CPYSHCQVLPAQPGECSG 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNRF3	NP_001193927.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		zf-RING_2	293..334	CDD:290367	28/40 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	608..693		22/107 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..758		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	849..875		7/25 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	892..936		3/7 (43%)
Rnf43	XP_006247152.1	ZNRF_3_ecto	85..187	CDD:408039	48/106 (45%)
		RING-H2_RNF43	270..316	CDD:319712	29/45 (64%)
		dnaA	598..>743	CDD:237605	41/191 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138786at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920