Protein Alignment BCAR3 and CG9098

DIOPT Version :10

• Sequence 1: NP_001398985.1
• Gene: BCAR3 / 8412
• HGNCID: 973
• Length: 868
• Species: Homo sapiens
• Sequence 2: NP_608979.2
• Gene: CG9098 / 33840
• FlyBaseID: FBgn0031762
• Length: 944
• Species: Drosophila melanogaster
• Alignment Length: 1019
• Identity: 283/1019 - (27%)
• Similarity: 413/1019 - (40%)
• Gaps: 261/1019 - (25%)

Human     8 DKSISTMRFTCLWSLGAASSDPSWPGERRKRQELRIMAAGKFASLPRNMPVNHQFPLASSMDLLS 72
            ::.:...|.:.||:.       .:....|:|::|.:|..            |.:..::..:|||.
  Fly    11 NRQVPNRRSSILWNF-------RYSNTVRRREDLAVMVH------------NSRMSISEWLDLLE 56

Human    73 SRSPLAEHRPD-------------------------AYQDVSIHGTLPRKKKGPPPIRSCDDFSH 112
                |.::..:                         |::...::..|..:.|.    |...:...
  Fly    57 ----LQQYEGNLQEFSTVDDVVDITDKELKQFGVRGAHRQRMVNSLLGVRAKR----RQSMNLEA 113

Human   113 MGTLPHSKSPRQNS-PVTQDGIQESPWQDRHG-----------------------ETFTF----- 148
            |.:.|.:...|:|| |:...|  |:| ||..|                       ||.|.
  Fly   114 MSSAPRAVPRRKNSCPLVYLG--ENP-QDMAGSGDSGPGVITTKSGKVLKQLTFDETSTIYEELR 175

Human   149 -----RDPH--LLDPTVE-YVKFSKERHIMDRTPE--------KLKKELEEELLLSSEDLRSHAW 197
                 ..||  :.|..:| |...:....:....|.        .|||.||.||.|.:.:||||||
  Fly   176 PRSKCNSPHWAIEDSRMEGYGSSNATTPLATAQPSPSEQQEAIALKKALEWELSLDARELRSHAW 240

Human   198 YHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQF 262
            |||.:|||.:|.:|||:|||||||..|.|.|:||:|:.|....||.:|:.||:....|.||||||
  Fly   241 YHGALPRQRAEEIVQREGDFLVRDCASQPDNYVLSCRSKAAVLHFVLNKLVLQPETVYERVQYQF 305

Human   263 EMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPL--------------RCLEEHYGTSP 313
            |.::||::|.|:..|||:.:|||..|||:|..|.|||.||              :.|....|.||
  Fly   306 EEDAFDTVPDLITFYVGSGKPISSASGALIQFPCNRTYPLSFYGHKIVGNQLHTQMLAGLRGLSP 370

Human   314 GQAREGS----------LTKGRPDVAKRLSLT-MGG-------------------------VQAR 342
            ..:..||          ..:..|...::..|: |.|                         .|.|
  Fly   371 LNSPMGSNGAVGAGMNATFRFEPQQQQQQQLSPMAGSPASPHCSPPRARREVPPPPRLPCKKQQR 435

Human   343 EQNL--PRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQ--------SESYLPIGCKLPPQSSG 397
            .|:|  .:..|:.|..|...|...:..:::.....:...|        ||.:|.  .|....|
  Fly   436 SQSLTPAQAMLVSNINKLQEQQLQMQELENGNGNGIMRFQTIARCNPTSEQHLE--SKFTTHS-- 496

Human   398 VDTSPCPNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSP 462
               .|.||     |.:..||....|.|:||.||.......|||: .|.|||||.|.|...|.:..
  Fly   497 ---LPRPN-----TSAAHALRQQAVARISSLARNCSLDSPSDSR-PPSPPPKPRKEPMAAVLAYQ 552

Human   463 SAWLNSE--------ANYCEL---------NPAFATGCGRGAKLPSCAQ----GSHTELLTAKQN 506
            ::..:|.        .:.||.         ||.|.|.......|.|..:    .:..||.|....
  Fly   553 ASGSDSGNGSGDSALGDACEASVQRGVIIKNPRFMTTSVSNGTLKSFTEFDVLAAEEELFTMAIE 617

Human   507 EAPGPRNSGVNYLILDDDDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPE 571
            |.                            ....::|...|||.||.:|               |
  Fly   618 EV----------------------------KTASKFDFENFVTLLLPSV---------------E 639

Human   572 NKPLETAMLKRAKELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQ 636
            ||||:...|...|.:.....||::|:|:..:|  :|..|.............|||||:|||||..
  Fly   640 NKPLDGDALNTFKMMLLETGPKLLAEHITRID--IALFLEEPSNEEDYYLSCSGLELLTLPHGKV 702

Human   637 LRLDIIERHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQ 701
            .|.|||||...:.:.:||.||.|...| |||..|||.||:|||.|.::|:|:.|.|:|..|.|.|
  Fly   703 FREDIIERTQCIKLMVAVTILTCQTDL-DRAQLLSKWIQIAVETKTALGNLFGFCAIMLGLCMQQ 766

Human   702 ITRLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMER---Q 763
            |.:|::.|..||.|||.:|..:|.:|:|...:::|.  |....| |.:||.::....|::|   .
  Fly   767 IQKLDQAWHILRQQYTDSAFTFEAKLRPTLSIMNEA--SNPQAP-NTTVPHVLLYALLIDRPVMD 828

Human   764 AVTFEGTD-----------MWEK--NDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQP-- 813
            .:.....|           .||.  :|....|...||..:|...:..:.||.||:.||....|
  Fly   829 IINHSNIDDRPALYHTCIAPWESKADDFGMTINFQHLDASRGFLKNLELYRKNAKIILEDASPRL 893

Human   814 DEEMNEICKTEFQMRLLWGSKGAQVNQTERYEKFNQILTALSRK 857
            ||.:.:..:|||.::.||||.||.....:|:.|..::||.::.|
  Fly   894 DELLADAFRTEFHVKFLWGSSGATAKAEDRHNKLEKVLTLMADK 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCAR3	NP_001398985.1	SH2_BCAR3	190..325	CDD:198200	69/158 (44%)
		RasGEF	587..862	CDD:214539	100/289 (35%)
CG9098	NP_608979.2	SAM_1	42..102	CDD:425739	7/75 (9%)
		SH2_BCAR3	233..367	CDD:198200	64/133 (48%)
		RasGEF	660..>797	CDD:470590	61/139 (44%)