Protein Alignment QRFPR and SIFaR

DIOPT Version :10

• Sequence 1: NP_937822.2
• Gene: QRFPR / 84109
• HGNCID: 15565
• Length: 431
• Species: Homo sapiens
• Sequence 2: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Alignment Length: 462
• Identity: 129/462 - (27%)
• Similarity: 215/462 - (46%)
• Gaps: 92/462 - (19%)

Human     4 LNITPEQFS--------RLLRDHNLTREQ--------FIALYR---LRPLVYTPELPGRAKLALV 49
            ||::|...|        :...|..|..||        |..|||   ...:||            .
  Fly   160 LNLSPATTSLISAAAATKSYNDSALRWEQLDGSVDFGFDPLYRHSLAMSMVY------------C 212

Human    50 LTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGG 114
            :..:::|.:.|.||:.|..||.|:..||||||.||.:||::|:|:..||:|.|::.||...|:.|
  Fly   213 VAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLG 277

Human   115 AFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSP 179
            ..:||.||::|..:|...:.::..::::|...:..|.|   |.|.|||..|:..:|::|::...|
  Fly   278 WLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLK---QMTKRRARIMIIGIWVIALVTTIP 339

Human   180 MW-----HVQQLEIKYDFL---YEKEHICCLEEWTSPVHQKIYTTFI---LVILFLLPLMVMLIL 233
             |     .|...|:..|.|   |.:....|.|.|.......:|  |:   ||..:|||:.::.:.
  Fly   340 -WLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLY--FLLANLVACYLLPMSLITLC 401

Human   234 YSKIGYELWIKKRVGDGSVLRTIHGK----EMSKIARKKKRAVI-MMVTVVALFAVCWAPFHVVH 293
            |..|    |||...      |:|.|:    :|.::.:|.|..|| |:|.||.||.:.|.|.:|:.
  Fly   402 YVLI----WIKVST------RSIPGESKDAQMDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIF 456

Human   294 MMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSP 358
            ..|::.:...:.:...:|.:..:.|.:|.|||..|||:|: :|:.:::.      :..:.|:.|.
  Fly   457 ARIKFGSDISQEEFEILKKVMPVAQWLGSSNSCINPILYS-VNKKYRRG------FAAIIKSRSC 514

Human   359 AQR---HGN----SGITMMRKKAKF---SLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRH 413
            ..|   :.|    |..|..||.:.:   |.|::|  .:||.|.|          ...|...|:||
  Fly   515 CGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKSP--SSKGNAVS----------YIYEHNSLRRH 567

Human   414 LALFRSE 420
            ..:.:.:
  Fly   568 NMMLKQD 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
QRFPR	NP_937822.2	7tmA_QRFPR	46..343	CDD:320333	96/312 (31%)
		TM helix 1	47..73	CDD:320333	7/25 (28%)
		TM helix 2	80..106	CDD:320333	12/25 (48%)
		TM helix 3	118..148	CDD:320333	7/29 (24%)
		TM helix 4	161..182	CDD:320333	7/25 (28%)
		TM helix 5	211..236	CDD:320333	8/27 (30%)
		TM helix 6	266..296	CDD:320333	13/30 (43%)
		TM helix 7	311..336	CDD:320333	10/24 (42%)
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	98/330 (30%)
		TM helix 1	210..236	CDD:320124	9/37 (24%)
		TM helix 2	243..269	CDD:320124	12/25 (48%)
		TM helix 3	281..311	CDD:320124	7/29 (24%)
		TM helix 4	322..340	CDD:320124	5/18 (28%)
		TM helix 5	379..404	CDD:320124	8/26 (31%)
		TM helix 6	429..459	CDD:320124	13/29 (45%)
		TM helix 7	474..498	CDD:320124	10/24 (42%)