Protein Alignment QRFPR and TrissinR

DIOPT Version :10

• Sequence 1: NP_937822.2
• Gene: QRFPR / 84109
• HGNCID: 15565
• Length: 431
• Species: Homo sapiens
• Sequence 2: NP_001097092.1
• Gene: TrissinR / 33812
• FlyBaseID: FBgn0085410
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 543
• Identity: 110/543 - (20%)
• Similarity: 183/543 - (33%)
• Gaps: 216/543 - (39%)

Human     9 EQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRS 73
            |:.|..:.|....|..||.||                       .|:|....|||.||..|||.|
  Fly   171 EKASEYIFDRTDVRIIFITLY-----------------------TLVFCCCFFGNLLVILVVTLS 212

Human    74 KAMRTVTNIFICSLALSDLLITFFCIPVTMLQNIS----DNWLGGAFICKMVPFVQSTAVVTEIL 134
            :.:|::||.|:.:||.:|..:..||:    :||:|    ::|:.|.|:|:|..||.|.:....|.
  Fly   213 RRLRSITNFFLANLAFADFCVGLFCV----MQNLSIYLIESWVFGEFLCRMYQFVHSLSYTASIF 273

Human   135 TMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMW---------HVQQLEIKY 190
            .:..|.:||:..:|||...|...|..|...::..||:.:.:..:|.:         |.|.
  Fly   274 ILVVICMERYFAIVHPITCKQILTAARLRMVIVTVWITSAVYSTPKFVFSKTIKNIHTQD----- 333

Human   191 DFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKR--------- 246
               .::|.||.|:.  ...:.|:......|:|:::||:||.:|||||...||...|
  Fly   334 ---GQEEEICVLDR--EMFNSKLLDMINFVLLYVMPLLVMTVLYSKIAIALWRSSRGLTPHVVQH 393

Human   247 -------------------------------------------------VG-------------- 248
                                                             ||
  Fly   394 QHQQPQQPSCQDIGMGMHNSMYHHHPHHHHHHHQHHQLQSAASSAGVVGVGLGGGGGGGPGPSLA 458

Human   249 -DGSVLRTIHGKEMSK------------------------------------------------- 263
             .||...::..|:.||
  Fly   459 SGGSSTTSLSRKQSSKYEKRGVSITESQLDNCKVSLEADRPIVSACRKTSFYHHGHAHHQRAGNA 523

Human   264 ----------------------IARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEY-------- 298
                                  :.|.::..|.|::..|..||:|..|:| ...|.:|
  Fly   524 SVGGGSGGAGAGATHMSHSSSNVLRARRGVVRMLIIFVLTFALCNLPYH-ARKMWQYWSRSYRGD 587

Human   299 SNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHG 363
            |||.        .::..:..::.:.||..||::|||::.||:|. :..:..|    ::...:...
  Fly   588 SNFN--------ALLTPLTFLVTYFNSGVNPLLYAFLSRNFRKG-MKELLLC----SWKKGKGKS 639

Human   364 NSGITMMRKKAKFSLRENPVEET 386
            :|..:|..|:........|.:.|
  Fly   640 SSNSSMHHKRKALQTHSLPTDTT 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
QRFPR	NP_937822.2	7tmA_QRFPR	46..343	CDD:320333	96/461 (21%)
		TM helix 1	47..73	CDD:320333	10/25 (40%)
		TM helix 2	80..106	CDD:320333	8/25 (32%)
		TM helix 3	118..148	CDD:320333	9/29 (31%)
		TM helix 4	161..182	CDD:320333	4/29 (14%)
		TM helix 5	211..236	CDD:320333	9/24 (38%)
		TM helix 6	266..296	CDD:320333	9/29 (31%)
		TM helix 7	311..336	CDD:320333	7/24 (29%)
TrissinR	NP_001097092.1	7tmA_Trissin_R	186..624	CDD:320140	100/484 (21%)
		TM helix 1	186..212	CDD:320140	14/48 (29%)
		TM helix 2	219..244	CDD:320140	10/28 (36%)
		TM helix 3	257..287	CDD:320140	9/29 (31%)
		TM helix 4	300..321	CDD:320140	4/20 (20%)
		TM helix 5	349..378	CDD:320140	12/28 (43%)
		TM helix 6	548..578	CDD:320140	10/30 (33%)
		TM helix 7	592..617	CDD:320140	7/24 (29%)