Protein Alignment QRFPR and npr-35

DIOPT Version :10

• Sequence 1: NP_937822.2
• Gene: QRFPR / 84109
• HGNCID: 15565
• Length: 431
• Species: Homo sapiens
• Sequence 2: NP_001023088.2
• Gene: npr-35 / 183681
• WormBaseID: WBGene00016842
• Length: 384
• Species: Caenorhabditis elegans
• Alignment Length: 356
• Identity: 96/356 - (26%)
• Similarity: 157/356 - (44%)
• Gaps: 52/356 - (14%)

Human    47 ALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNW 111
            |:..||||       ||..|...|...|.:...|:..|.||||:||.|.:.|:|.|::.:|...|
 Worm    41 AVFFTGVL-------GNTFVVLAVWAHKNLNITTDYLILSLALADLFILWICLPTTLINSIFTEW 98

Human   112 LGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFK--MKW--QYTNRRAFTMLGVVWLV 172
            |.|.|.|::..:..::.....:.|:..:..:|:..:.|..|  ..|  :||....|    .||||
 Worm    99 LWGQFFCRLSTWANASTSFASVYTLVAVTADRYLAICHTLKYNTSWDREYTKYVIF----AVWLV 159

Human   173 AVIVGSPMWHVQQLEIKYDFLYEKE-----HICCLEEWTSPVHQKIYTTFI-LVILFLLPLMVML 231
            |.|.|.|.|:      .||.:..:|     .:|     ||...||:|..|: |::.|::|..::.
 Worm   160 AAIFGIPNWY------NYDLIVWQEGSYGYRLC-----TSQTDQKLYFLFVNLLLAFIVPFGLIS 213

Human   232 ILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMI 296
            .||::|...:         |..|::.....::..|.|.|...||:||:.:||.||.|.:.:....
 Worm   214 GLYTRIFITV---------STHRSLAVDARAREDRVKLRVATMMLTVIIVFACCWLPLYCIFTYF 269

Human   297 EYSNFEKEYDD---VTIKMIFAIVQIIGFSNSICNPIVYAFMNENFK---KNVLSAVCYCIVNKT 355
            .:  |..:..|   :|..:|..|.|.:...:|..|||:|...:..::   |::|...|.....:.
 Worm   270 FF--FADQRSDLFQITSMLIRPIFQWMSLLSSSLNPIIYIAYSHKYRRAFKSILLMPCKTRYERV 332

Human   356 FSPAQRHGNSGITMMRKKAKFSLRENPVEET 386
            .|...|..:.|   .:..|..|:.....|.|
 Worm   333 RSTILRRHSRG---FKSTATISMSNFGTEPT 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
QRFPR	NP_937822.2	7tmA_QRFPR	46..343	CDD:320333	87/311 (28%)
		TM helix 1	47..73	CDD:320333	9/25 (36%)
		TM helix 2	80..106	CDD:320333	12/25 (48%)
		TM helix 3	118..148	CDD:320333	3/29 (10%)
		TM helix 4	161..182	CDD:320333	9/20 (45%)
		TM helix 5	211..236	CDD:320333	9/25 (36%)
		TM helix 6	266..296	CDD:320333	12/29 (41%)
		TM helix 7	311..336	CDD:320333	8/24 (33%)
npr-35	NP_001023088.2	7tm_GPCRs	33..317	CDD:475119	86/308 (28%)
		TM helix 1	35..59	CDD:410628	9/24 (38%)
		TM helix 2	68..90	CDD:410628	10/21 (48%)
		TM helix 3	106..128	CDD:410628	1/21 (5%)
		TM helix 4	151..167	CDD:410628	8/19 (42%)
		TM helix 5	194..217	CDD:410628	6/22 (27%)
		TM helix 6	245..267	CDD:410628	9/21 (43%)
		TM helix 7	285..310	CDD:410628	8/24 (33%)