Protein Alignment QRFPR and npr-1

DIOPT Version :10

• Sequence 1: NP_937822.2
• Gene: QRFPR / 84109
• HGNCID: 15565
• Length: 431
• Species: Homo sapiens
• Sequence 2: NP_508816.1
• Gene: npr-1 / 180752
• WormBaseID: WBGene00003807
• Length: 457
• Species: Caenorhabditis elegans
• Alignment Length: 387
• Identity: 104/387 - (26%)
• Similarity: 188/387 - (48%)
• Gaps: 68/387 - (17%)

Human    41 PGRAKLALV--LTGVL-IFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVT 102
            |.::..|:|  ||..| :|.|.||||..:.||....||:.:|.||||.:||.||.::....:|:|
 Worm    19 PSQSIYAIVPFLTVYLFLFFLGLFGNVTLIYVTCSHKALLSVQNIFILNLAASDCMMCILSLPIT 83

Human   103 MLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLG 167
            .:.|:..||..|..:|.::|.:|..::.....::..||::|:..:|.|...  ..:.|.||....
 Worm    84 PITNVYKNWYFGNLLCHLIPCIQGISIFVCTFSLGAIALDRYILVVRPHST--PLSQRGAFLTTV 146

Human   168 VVWLVAVIVGSP-MWHVQQLEIKYDFLYEKEHIC---CLEEWTSPVHQKIYTTFILVILFLLPLM 228
            ::|:::.:|..| .:::|.:|      |.:|.||   |.|:|.|...::.||..:::..|::|..
 Worm   147 LLWILSFVVTLPYAFNMQMIE------YTEERICGYFCTEKWESAKSRRAYTMIVMLAQFVVPFA 205

Human   229 VMLILYSKI------GYELWIKKRVGDGSVLRT-----IHG----------------KEMSKIAR 266
            ||...|:.|      ..:..|:|.|...|.|.:     .||                ||..::..
 Worm   206 VMAFCYANIVSVLSKRAQTKIRKMVERTSALESSCAFPSHGLEQYENELNEFLDKQEKEKQRVVL 270

Human   267 KKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEY-----DDVTIKMIFAI-VQIIGFSNS 325
            :.:|...::||:|..|.:.|.|.:|:.::|||.:.:..:     ||..|..:..: ...|..||:
 Worm   271 QNRRTTSILVTMVVWFGITWLPHNVISLIIEYDDTQSFFRLYGRDDYDISYLLNLFTHSIAMSNN 335

Human   326 ICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETK 387
            :.||::||::|.:|::         :|.||:     .|:      |:|:...:.:..|.:||
 Worm   336 VLNPVLYAWLNPSFRQ---------LVIKTY-----FGD------RRKSDRIINQTSVYKTK 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
QRFPR	NP_937822.2	7tmA_QRFPR	46..343	CDD:320333	94/336 (28%)
		TM helix 1	47..73	CDD:320333	13/28 (46%)
		TM helix 2	80..106	CDD:320333	10/25 (40%)
		TM helix 3	118..148	CDD:320333	6/29 (21%)
		TM helix 4	161..182	CDD:320333	5/21 (24%)
		TM helix 5	211..236	CDD:320333	7/24 (29%)
		TM helix 6	266..296	CDD:320333	8/29 (28%)
		TM helix 7	311..336	CDD:320333	7/25 (28%)
npr-1	NP_508816.1	7tmA_NPYR-like	27..351	CDD:320331	93/331 (28%)
		TM helix 1	28..54	CDD:320331	11/25 (44%)
		TM helix 2	61..86	CDD:320331	10/24 (42%)
		TM helix 3	99..129	CDD:320331	6/29 (21%)
		TM helix 4	140..161	CDD:320331	5/20 (25%)
		TM helix 5	188..217	CDD:320331	8/28 (29%)
		TM helix 6	270..300	CDD:320331	8/29 (28%)
		TM helix 7	321..346	CDD:320331	7/24 (29%)