Protein Alignment QRFPR and npr-2

DIOPT Version :10

• Sequence 1: NP_937822.2
• Gene: QRFPR / 84109
• HGNCID: 15565
• Length: 431
• Species: Homo sapiens
• Sequence 2: NP_501701.2
• Gene: npr-2 / 177790
• WormBaseID: WBGene00003808
• Length: 430
• Species: Caenorhabditis elegans
• Alignment Length: 389
• Identity: 96/389 - (24%)
• Similarity: 173/389 - (44%)
• Gaps: 76/389 - (19%)

Human     2 QALNITPEQFSRLLRDH-NLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVL---IFALALFG 62
            |.:|.|.|...|.:..| ::|.|         |.|            ||...:|   ||.|.:.|
 Worm    43 QMINETEETCDRYIDKHPDMTNE---------PTV------------LVTFSLLYLHIFLLGILG 86

Human    63 NALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQST 127
            |:.|.|:..:.:.::||.||||.:|..|::|:....:|:|.:.|:...|...:.:||::|.||..
 Worm    87 NSAVLYLTMKHRQLQTVQNIFILNLCASNVLMCLTSLPITFITNVYKQWFFSSPVCKLIPLVQGA 151

Human   128 AVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPM-WH--VQQLEIK 189
            ::.....:::.||::|:..:|.|.|.|  .::|.|..:..::|:::|:|..|. |:  |::|
 Worm   152 SIFVSTFSLSAIALDRYNLVVRPHKQK--LSSRSAMMIALLIWVISVVVCMPYGWYMDVEKL--- 211

Human   190 YDFLYEKEHIC---CLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKI------GYELWIKK 245
                   ..:|   |.|.|.....:|.||..:|:..||.|...|...|..|      ..|..:||
 Worm   212 -------NGLCGEYCSEHWPLAEVRKGYTFLVLITQFLFPFATMAFCYYNIFSRLRQRVETKLKK 269

Human   246 ---------------------RVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPF 289
                                 .:...:|...:..|:...:..:::|...::..:|.|||..|.|.
 Worm   270 LSERSQLLENSTTCGTTNHIVSINAEAVQNGLENKQRLAVLAQQRRTTTILSCMVLLFAFTWLPH 334

Human   290 HVVHMMIEYSNFEKEYDDVTIK------MIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAV 347
            :||.:||||..|....|:.:..      ::.....:|....::.||.:||::|..||:.::..:
 Worm   335 NVVTLMIEYDGFFFHSDETSATSTDHTYIVSMTAHLISMLTNVTNPFLYAWLNPMFKEMLIKTL 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
QRFPR	NP_937822.2	7tmA_QRFPR	46..343	CDD:320333	86/338 (25%)
		TM helix 1	47..73	CDD:320333	10/28 (36%)
		TM helix 2	80..106	CDD:320333	9/25 (36%)
		TM helix 3	118..148	CDD:320333	8/29 (28%)
		TM helix 4	161..182	CDD:320333	5/21 (24%)
		TM helix 5	211..236	CDD:320333	9/24 (38%)
		TM helix 6	266..296	CDD:320333	9/29 (31%)
		TM helix 7	311..336	CDD:320333	5/30 (17%)
npr-2	NP_501701.2	7tmA_NPYR-like	70..394	CDD:320331	85/335 (25%)
		TM helix 1	71..97	CDD:320331	8/25 (32%)
		TM helix 2	104..129	CDD:320331	9/24 (38%)
		TM helix 3	142..172	CDD:320331	8/29 (28%)
		TM helix 4	183..204	CDD:320331	5/20 (25%)
		TM helix 5	229..258	CDD:320331	10/28 (36%)
		TM helix 6	311..341	CDD:320331	9/29 (31%)
		TM helix 7	362..387	CDD:320331	5/24 (21%)