Protein Alignment QRFPR and npr-34

DIOPT Version :10

• Sequence 1: NP_937822.2
• Gene: QRFPR / 84109
• HGNCID: 15565
• Length: 431
• Species: Homo sapiens
• Sequence 2: NP_497057.2
• Gene: npr-34 / 175131
• WormBaseID: WBGene00013187
• Length: 613
• Species: Caenorhabditis elegans
• Alignment Length: 459
• Identity: 101/459 - (22%)
• Similarity: 186/459 - (40%)
• Gaps: 102/459 - (22%)

Human    40 LPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTML 104
            |||...|.:.|.|.:       ||::|.:||.|.|.||.|||||:.||:.:||.:.:||:|:..:
 Worm    74 LPGFLYLTVFLVGTI-------GNSMVIFVVNRFKRMRNVTNIFLASLSTADLCLIWFCVPIMFM 131

Human   105 QNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVV 169
            :.:|..|..|.|.|..|.::|.......:||||.|:.||...:.:|.:..|..:..||..::.::
 Worm   132 KYMSHTWSMGRFACYSVHYIQQFTCFCSVLTMTMISFERFLAIAYPMRNIWFSSIGRAKKVILLI 196

Human   170 WLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVH---------QKIYTTFILVILFLL 225
            |:.:.::..|.......|.......::.|.|   ....|..         .|.|..:.|::|.:.
 Worm   197 WMSSAVLAVPTAVRMDYETNLSLSGQRVHWC---RRRFPAQFLGYPRTSLNKAYAMYQLLLLIIF 258

Human   226 PLMVMLILYSKIGYELW---------------IKKRVGD----------------------GSVL 253
            |::.|.|.|:::...::               ..|...|                      .:.:
 Worm   259 PVLTMSICYARVSAIVYKSSKDRVILSQAMVAFSKAATDAVTFSGYSAIPMITTSRNLKTANTTI 323

Human   254 RTIHGKEMSKIAR-KKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIV 317
            ::......:::|. .||:.|.|::::|.::.|||.|..|..::..:....:..:..|:|.:....
 Worm   324 KSYSNHRNNRVAEANKKQIVQMLISIVCMYTVCWLPTIVDELLTSFGYICRTSNTQTLKHMRMGF 388

Human   318 QIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNS---GITMMRKK------ 373
            ..:.:..|..|||:|||:::||:             .||..|.....|   |:..||.:
 Worm   389 NALTYCQSCINPILYAFISQNFR-------------STFKTAYSRMKSRLQGVEEMRSRMGSCSS 440

Human   374 -AKFSLRENPVEETKGEAFSDGNI---------------EVKLCEQTEEKKKLKRHLALFRSELA 422
             :..|.|..  ....|.:|:...:               ::.||..|.:....:.     :|.:|
 Worm   441 ASMMSTRNQ--HRIYGSSFNTLTVPGRSMITPNMSRDVSQLSLCRPTSQMSFCRP-----KSPMA 498

Human   423 ENSP 426
            .:||
 Worm   499 GDSP 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
QRFPR	NP_937822.2	7tmA_QRFPR	46..343	CDD:320333	80/343 (23%)
		TM helix 1	47..73	CDD:320333	7/25 (28%)
		TM helix 2	80..106	CDD:320333	11/25 (44%)
		TM helix 3	118..148	CDD:320333	10/29 (34%)
		TM helix 4	161..182	CDD:320333	4/20 (20%)
		TM helix 5	211..236	CDD:320333	8/24 (33%)
		TM helix 6	266..296	CDD:320333	10/30 (33%)
		TM helix 7	311..336	CDD:320333	8/24 (33%)
npr-34	NP_497057.2	7tmA_GPRnna14-like	75..414	CDD:320132	82/361 (23%)
		TM helix 1	75..100	CDD:320132	10/31 (32%)
		TM helix 2	107..132	CDD:320132	11/24 (46%)
		TM helix 3	145..175	CDD:320132	10/29 (34%)
		TM helix 4	188..209	CDD:320132	4/20 (20%)
		TM helix 5	244..269	CDD:320132	8/24 (33%)
		TM helix 6	337..367	CDD:320132	10/29 (34%)
		TM helix 7	382..407	CDD:320132	8/24 (33%)