Protein Alignment ZIC4 and SWI5

DIOPT Version :10

• Sequence 1: NP_001161850.1
• Gene: ZIC4 / 84107
• HGNCID: 20393
• Length: 384
• Species: Homo sapiens
• Sequence 2: NP_010430.1
• Gene: SWI5 / 851724
• SGDID: S000002553
• Length: 709
• Species: Saccharomyces cerevisiae
• Alignment Length: 439
• Identity: 94/439 - (21%)
• Similarity: 149/439 - (33%)
• Gaps: 150/439 - (34%)

Human    28 KNAFWLERIENNNTLWEKA-QSQKMRYKTSLVMRKRLRLYRN-------------TLKESSSSSG 78
            :..:.|:|..::.|:.... |.....:..||:..|::|...|             |.|...||:.
Yeast   268 RQKYCLQRKNSSGTVGPLCFQELNEGFNDSLISPKKIRSNPNENLSSKTKFITPFTPKSRVSSAT 332

Human    79 HHGPQLTAASSPSVFPGLHEEPPQASPSRPLN-GLLRLGLPGDMYARPEP-------------FP 129
            .:...:|..:....|....|:.......:||. |:..||.||     |.|             .|
Yeast   333 SNSANITPNNLRLDFKINVEDQESEYSEKPLGLGIELLGKPG-----PSPTKSVSLKSASVDIMP 392

Human   130 --PG-----PAARSDALAAA---------AALHGYGGMN---LTVNLAAPHGPGAFFRYMRQPIK 175
              ||     |:....:|:::         ..|| :..::   |.:|.|.||        ::.|.:
Yeast   393 TIPGSVNNTPSVNKVSLSSSYIDQYTPRGKQLH-FSSISENALGINAATPH--------LKPPSQ 448

Human   176 Q-------------ELICKWLAADG----------------TATPSLCSKT--------FST-MH 202
            |             .::.|....:|                |.:|.|.|::        |.| :.
Yeast   449 QARHREGVFNDLDPNVLTKNTDNEGDDNEENEPESRFVISETPSPVLKSQSKYEGRSPQFGTHIK 513

Human   203 ELVTHVTVEHVGGPEQANHICFWEECPRQGKPFKAKYKLV----NHIRVHTGEKP---FPCPFPG 260
            |:.|:.|                      ..|.|...||.    ..|..:..|.|   |.|.|||
Yeast   514 EINTYTT----------------------NSPSKITRKLTTLPRGSIDKYVKEMPDKTFECLFPG 556

Human   261 CGKVFARSENLKIHKRTHTGEKPFRCEFEGCERRFANSSDRKKHSHVHTSDKPYTCKVRGCDKCY 325
            |.|.|.|..|::.|.:||..::|:.|:..||::.|..:.|..:|...| .:|.|.|.   |.|.:
Yeast   557 CTKTFKRRYNIRSHIQTHLEDRPYSCDHPGCDKAFVRNHDLIRHKKSH-QEKAYACP---CGKKF 617

Human   326 THPSSL---RKHMKVHG----------RSP-----PPSSGYDSATPSAL 356
            ....:|   |..|...|          |||     |...|..|.:.|.:
Yeast   618 NREDALVVHRSRMICSGGKKYENVVIKRSPRKRGRPRKDGTSSVSSSPI 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZIC4	NP_001161850.1	zf_ZIC	172..216	CDD:436441	13/81 (16%)
		COG5048	<192..338	CDD:227381	43/164 (26%)
		C2H2 Zn finger	228..248	CDD:275368	5/23 (22%)
		C2H2 Zn finger	256..278	CDD:275368	10/21 (48%)
		C2H2 Zn finger	286..308	CDD:275368	6/21 (29%)
		C2H2 Zn finger	316..338	CDD:275368	6/24 (25%)
SWI5	NP_010430.1	COG5048	124..630	CDD:227381	85/401 (21%)
		C2H2 Zn finger	552..574	CDD:275368	10/21 (48%)
		C2H2 Zn finger	582..604	CDD:275368	6/21 (29%)
		C2H2 Zn finger	611..627	CDD:275368	4/18 (22%)