DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZIC4 and opa

DIOPT Version :9

Sequence 1:	NP_001161850.1	Gene:	ZIC4 / 84107	HGNCID:	20393	Length:	384	Species:	Homo sapiens
Sequence 2:	NP_001368991.1	Gene:	opa / 40605	FlyBaseID:	FBgn0003002	Length:	688	Species:	Drosophila melanogaster

Alignment Length:	349	Identity:	174/349 - (49%)
Similarity:	212/349 - (60%)	Gaps:	60/349 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    74 SSSSGHHGPQLTAASSPSVFPGLHEEPPQASP------SRPLNG-----LLRLGLPGDMYARPEP 127
            :.|:|    |.:||:...:|.|.   |.||:.      ..|.:.     .:|:|: .|.||...|
  Fly    99 AGSAG----QASAAADSMLFSGF---PAQAAELGSGFGQHPFHSHHHHHQMRMGM-ADAYAAGHP 155

Human   128 ------FPPG----PAARSDALAAAAALHGYGGMNLTVNLAAPHGPGAFFRYMR-QP------IK 175
                  ||..    |.....:..|.:|:|             |.|.|||.|||| ||      :|
  Fly   156 YNHHGNFPTAAVHHPVVHHPSHHAMSAMH-------------PAGAGAFLRYMRHQPASSASSVK 207

Human   176 QELICKWLAAD--GTATP---SLCSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPRQGKPF 235
            ||:.|.|:..|  |...|   ..|:|.|.:|||:|||:|||||||||...|.|||..|.|.|:||
  Fly   208 QEMQCLWIDPDQPGLVPPGGRKTCNKVFHSMHEIVTHLTVEHVGGPECTTHACFWVGCSRNGRPF 272

Human   236 KAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFRCEFEGCERRFANSSD 300
            |||||||||||||||||||.||.||||||||||||||||||||||||||:||.|||:||||||||
  Fly   273 KAKYKLVNHIRVHTGEKPFACPHPGCGKVFARSENLKIHKRTHTGEKPFKCEHEGCDRRFANSSD 337

Human   301 RKKHSHVHTSDKPYTCKVRGCDKCYTHPSSLRKHMKVHGR--SPPPSSGYDS----ATPSALVSP 359
            ||||||||||||||.|::.||||.|||||||||||||||.  ...||.||||    ::.|::::.
  Fly   338 RKKHSHVHTSDKPYNCRINGCDKSYTHPSSLRKHMKVHGNVDEKSPSHGYDSEGEESSSSSIITG 402

Human   360 SSDCGHKSQVASSAAVAARTADLS 383
            .:.....:::..||..::..:.||
  Fly   403 GAQTPPSTRLDGSAGSSSGVSSLS 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZIC4	NP_001161850.1	COG5048	<192..338	CDD:227381	118/145 (81%)
		C2H2 Zn finger	228..248	CDD:275368	16/19 (84%)
		zf-H2C2_2	241..267	CDD:290200	23/25 (92%)
		C2H2 Zn finger	256..278	CDD:275368	20/21 (95%)
		zf-H2C2_2	270..297	CDD:290200	23/26 (88%)
		C2H2 Zn finger	286..308	CDD:275368	19/21 (90%)
		zf-C2H2	314..338	CDD:278523	18/23 (78%)
		C2H2 Zn finger	316..338	CDD:275368	17/21 (81%)
opa	NP_001368991.1	zf_ZIC	206..253	CDD:408166	23/46 (50%)
		C2H2 Zn finger	265..285	CDD:275368	16/19 (84%)
		SFP1	<287..373	CDD:227516	75/85 (88%)
		C2H2 Zn finger	293..315	CDD:275368	20/21 (95%)
		C2H2 Zn finger	323..345	CDD:275368	19/21 (90%)
		C2H2 Zn finger	353..375	CDD:275368	17/21 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I8980
eggNOG	1	0.900	-	-		E33208_3BCH8
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2358
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D268347at33208
OrthoFinder	1	1.000	-	-		FOG0000467
OrthoInspector	1	1.000	-	-		otm41195
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19818
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4702
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	10.090