DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZIC4 and zic4

DIOPT Version :9

Sequence 1:	NP_001161850.1	Gene:	ZIC4 / 84107	HGNCID:	20393	Length:	384	Species:	Homo sapiens
Sequence 2:	XP_031758299.1	Gene:	zic4 / 100493609	XenbaseID:	XB-GENE-1033015	Length:	533	Species:	Xenopus tropicalis

Alignment Length:	317	Identity:	225/317 - (70%)
Similarity:	250/317 - (78%)	Gaps:	10/317 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    73 SSSSSGHHGPQLTAASSPSVFPGLHEEPPQASP-SRPLNGLLRLGLPGDMYARPEPFPPGPAARS 136
            :.|..||||....|.:.| .|.|..|:...|:| .:||||.:|||||||||.|.:.|.. |..|:
Frog   184 TGSYPGHHGHHTEAGNHP-YFSGAPEQASHATPGGQPLNGQIRLGLPGDMYTRSDHFTQ-PVTRT 246

Human   137 DALAAAAALHGYGGMNLTVNLAA-PHGPGAFFRYMRQPIKQELICKWLAADGTATPSLCSKTFST 200
            |.. |:.:||.|.||||.:|:.. .||||||||||||.|||||||||:..: .....||||||||
Frog   247 DHF-ASPSLHSYCGMNLNMNITPHHHGPGAFFRYMRQAIKQELICKWIEEE-HHPKKLCSKTFST 309

Human   201 MHELVTHVTVEHVGGPEQANHICFWEECPRQGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVF 265
            ||||||||||||||||||:|||||||||||:||||||||||||||||||||||||||||||||||
Frog   310 MHELVTHVTVEHVGGPEQSNHICFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVF 374

Human   266 ARSENLKIHKRTHTGEKPFRCEFEGCERRFANSSDRKKHSHVHTSDKPYTCKVRGCDKCYTHPSS 330
            |||||||||||||||||||:||||||:||||||||||||||||||||||.||||||||.||||||
Frog   375 ARSENLKIHKRTHTGEKPFKCEFEGCDRRFANSSDRKKHSHVHTSDKPYNCKVRGCDKSYTHPSS 439

Human   331 LRKHMKVHGRSPPPSSGYDSATPSALVSPSSDCGHKSQVASS---AAVAARTADLSE 384
            ||||||||.:||||||||:|:.|| |||||||.|......||   ...:::.|:|||
Frog   440 LRKHMKVHCKSPPPSSGYESSIPS-LVSPSSDSGQDPGATSSQPEPPPSSQGANLSE 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZIC4	NP_001161850.1	COG5048	<192..338	CDD:227381	138/145 (95%)
		C2H2 Zn finger	228..248	CDD:275368	18/19 (95%)
		zf-H2C2_2	241..267	CDD:290200	25/25 (100%)
		C2H2 Zn finger	256..278	CDD:275368	21/21 (100%)
		zf-H2C2_2	270..297	CDD:290200	24/26 (92%)
		C2H2 Zn finger	286..308	CDD:275368	20/21 (95%)
		zf-C2H2	314..338	CDD:278523	21/23 (91%)
		C2H2 Zn finger	316..338	CDD:275368	20/21 (95%)
zic4	XP_031758299.1	zf_ZIC	282..325	CDD:408166	32/43 (74%)
		COG5048	<298..447	CDD:227381	138/148 (93%)
		C2H2 Zn finger	337..357	CDD:275368	18/19 (95%)
		C2H2 Zn finger	365..387	CDD:275368	21/21 (100%)
		C2H2 Zn finger	395..417	CDD:275368	20/21 (95%)
		C2H2 Zn finger	425..447	CDD:275368	20/21 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I34343
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H32075
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D175409at32523
OrthoFinder	1	1.000	-	-		FOG0000467
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19818
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.110