Protein Alignment USP44 and not

DIOPT Version :9

• Sequence 1: XP_005269229.1
• Gene: USP44 / 84101
• HGNCID: 20064
• Length: 743
• Species: Homo sapiens
• Sequence 2: NP_001287106.1
• Gene: not / 40030
• FlyBaseID: FBgn0013717
• Length: 496
• Species: Drosophila melanogaster
• Alignment Length: 699
• Identity: 150/699 - (21%)
• Similarity: 231/699 - (33%)
• Gaps: 263/699 - (37%)

Human    28 HCVDCNTTE-SIWACLSCSHVACGRYIEEHALKHFQESSHPVALEVNEMYVFCYLCDDYVLNDNT 91
            :|.:|.:.. .::|||.|.:..|.   ..|...|.:...|.||||::...::||.|.|::. |..
  Fly    45 NCFECGSYGIQLYACLHCIYFGCR---GAHITSHLRSKKHNVALELSHGTLYCYACRDFIY-DAR 105

Human    92 TGDLKLLRRTLSAIKSQNYHCTTRSGRFLRSMGTGDDSYFLHDGAQSLLQSEDQLYTALWHRRRI 156
            :.:..|:.|.|.|...|            :|:|
  Fly   106 SREYALINRKLEAKDLQ------------KSIG-------------------------------- 126

Human   157 LMGKIFRTWFEQSPIGRKKQEEPFQEKIVVKREVKKRRQELEYQVKAELESMPPRKSLRLQGLAQ 221
                    |
  Fly   127 --------W-------------------------------------------------------- 127

Human   222 STIIEIVSVQVPAQTPASPAKDKVLSTSENEISQKVSDSSVKRRPIVTPGVTGLRNLGNTCYMNS 286
                      || ..|.:...:.:|:.:...:.          ||..|.|:.||.|||.||:||.
  Fly   128 ----------VP-WVPTTKETNLLLANARRRLV----------RPNQTIGLRGLLNLGATCFMNC 171

Human   287 VLQVLSHLLIFRQCFLKLDLNQWLAMTASEKTRSCKHPPVTDTVVYQMNECQEKDTGFVCSRQSS 351
            ::|.|.|.                             |.::|..:...::|..|
  Fly   172 IVQALVHT-----------------------------PLLSDYFMSDRHDCGSK----------- 196

Human   352 LSSGLSGGASKGRKMELIQPKEPTSQYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAF 416
                                    |.:..|..|:..|||..:||..:.:|...:||.:|......
  Fly   197 ------------------------SSHKCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHL 237

Human   417 RGYAQQDAQEFLCELLDKIQR-------ELETTGTSLPALIPT-----SQRKLIKQVLNVVNNIF 469
            .||.||||.||....||.:.|       |.|:...|..:...|     |......|...:::.||
  Fly   238 AGYEQQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIF 302

Human   470 HGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCSGKDIASQPCLVTEMLAKFTETEALEGKI 534
            .|.|.|.|.|.||:..|.|.:||||:||:..|.....|    ..|..:.:.|.::|..|.|....
  Fly   303 TGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTTHGG----VTPKTLIDCLERYTRAEHLGSAA 363

Human   535 YV-CDQCNSKRRRFSSKPVVLTEAQKQLMICHLPQVLRLHLKRFSTNSLCILINTLLAMLRSSNG 598
            .: |..|.|.:           |:.||..:..||.|:..|||||..::|.
  Fly   364 KIKCSTCKSYQ-----------ESTKQFSLRTLPSVVSFHLKRFEHSALI--------------- 402

Human   599 KYDQQTEKITGWSGRNNREKIGVHVGFEEILNMEPYCCRETLKSLRPECFIYDLSAVVMHHGKGF 663
                             ..||...:.|....:|.|:...:  |:...: |.:.|.|||.|.|. .
  Fly   403 -----------------DRKISSFIQFPVEFDMTPFMSEK--KNAYGD-FRFSLYAVVNHVGT-I 446

Human   664 GSGHYTAYCYNSEGGFWVHCNDSKLSMCTMDEVCKAQAYILFYTQRVTE 712
            .:||||||..:.: ..||.|:|..::|.::.:|..::.|:|||.:.|.|
  Fly   447 DTGHYTAYVRHQK-DTWVKCDDHVITMASLKQVLDSEGYLLFYHKNVLE 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
USP44	XP_005269229.1	zf-UBP	29..90	CDD:280334	18/61 (30%)
		UCH	272..706	CDD:278850	111/446 (25%)
		Peptidase_C19	274..707	CDD:271592	112/445 (25%)
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	18/60 (30%)
		Peptidase_C19D	158..489	CDD:239125	112/446 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810