DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CASP8 and Decay

DIOPT Version :9

Sequence 1:	NP_001073594.1	Gene:	CASP8 / 841	HGNCID:	1509	Length:	538	Species:	Homo sapiens
Sequence 2:	NP_477462.1	Gene:	Decay / 42008	FlyBaseID:	FBgn0028381	Length:	308	Species:	Drosophila melanogaster

Alignment Length:	264	Identity:	84/264 - (31%)
Similarity:	130/264 - (49%)	Gaps:	38/264 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   293 GYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKI 357
            |..||:|:.:....:::|          ||..|...:..|.:...|:::..||.|..:|.:.||.
  Fly    56 GIALILNHKDVKGQKQRV----------GTERDRDDMEATLQGFGFDVRTFDDLTFSEINDTLKE 110

Human   358 YQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGD 422
            ....|||..|||:..::|||.:|.:|..| ...|:..|.:.|.|..|.:|..|||:||||||:|.
  Fly   111 VAREDHSQNDCFVLAVMSHGTEGKVYAKD-MSYPVERLWNPFLGDNCKTLKNKPKLFFIQACRGA 174

Human   423 NYQKGIPVET------DSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYI 481
            |.:|.:...:      :...:|...:   .|.|..||..||.|:..:|.:...|:||..:|:|:|
  Fly   175 NLEKAVEFSSFAVMTRELVPEPAAAV---QPITYAIPSTADILVFYSTFDKFFSFRNVDDGSWFI 236

Human   482 QSLCQSLRERC------PRGDDILTILTEVN------YEVSNKDDKKNMGKQMPQ------PTFT 528
            ||||:.|.:..      |.|.::|.:||.||      |:.:.|::..|..|:||.      .||.
  Fly   237 QSLCRVLDQAAANEAATPEGVELLRLLTAVNRKVAYEYQSNTKNEALNQMKEMPNFMSTLTKTFQ 301

Human   529 LRKK 532
            ||.|
  Fly   302 LRVK 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CASP8	NP_001073594.1	DED_Caspase_8_r1	62..143	CDD:260041
		DD	157..239	CDD:301326
		CASc	284..536	CDD:237997	84/264 (32%)
Decay	NP_477462.1	CASc	54..302	CDD:237997	81/259 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152735
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3573
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.700