DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ULK1 and Aduk

DIOPT Version :9

Sequence 1:	XP_011537100.1	Gene:	ULK1 / 8408	HGNCID:	12558	Length:	1073	Species:	Homo sapiens
Sequence 2:	NP_731331.1	Gene:	Aduk / 41112	FlyBaseID:	FBgn0037679	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	269	Identity:	109/269 - (40%)
Similarity:	166/269 - (61%)	Gaps:	14/269 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    14 FEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAK-SQTLLGKEIKILKELKHENIVA 77
            ||...|  :|.|::|.|:|.||:::.... |:|.:....|:: |:..|..||::|:||||:.||.
  Fly     9 FEILEK--LGAGSYATVYKARHKKQRTYH-AIKYVEMSTLSQTSRENLITEIRLLRELKHKYIVT 70

Human    78 LYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQ 142
            |.||.....::|:|:||||.|:|:.::...:.|.|.|.|.||:|:|.|::.:.:..:.|.|||||
  Fly    71 LQDFFWDDKNIYIVLEYCNAGNLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSHFDLKPQ 135

Human   143 NILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSI 207
            |:||:..|      |::.:|:||||||::|:...:...|.|||:|||||::....||.|||||||
  Fly   136 NLLLTRGA------NNVSLKVADFGFAQHLKLGEINQQLKGSPLYMAPEIVRKHQYDAKADLWSI 194

Human   208 GTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIP--RETSAPLRQLLLALLQRNHKDRMDFD 270
            |.|:|:||.||||:.:.:.::|.|...|.:.:  |:|  ...|.....||..||......|:.|.
  Fly   195 GVILYECLFGKAPYSSRTIEELLLRIRKAEAI--TLPPNARISNECHDLLRRLLAHEPTARISFA 257

Human   271 EFFHHPFLD 279
            :||.|||||
  Fly   258 DFFAHPFLD 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ULK1	XP_011537100.1	STKc_ULK1	13..279	CDD:271104	107/267 (40%)
		S_TKc	16..278	CDD:214567	104/264 (39%)
		DUF3543	860..1067	CDD:288883
Aduk	NP_731331.1	S_TKc	9..265	CDD:214567	106/266 (40%)
		PKc_like	13..264	CDD:304357	103/261 (39%)
		MIT_2	274..348	CDD:239147
		MIT	407..472	CDD:282117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5656
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850