Protein Alignment ULK1 and Atg1

DIOPT Version :9

• Sequence 1: XP_011537100.1
• Gene: ULK1 / 8408
• HGNCID: 12558
• Length: 1073
• Species: Homo sapiens
• Sequence 2: NP_001163433.1
• Gene: Atg1 / 39454
• FlyBaseID: FBgn0260945
• Length: 855
• Species: Drosophila melanogaster
• Alignment Length: 1136
• Identity: 368/1136 - (32%)
• Similarity: 478/1136 - (42%)
• Gaps: 376/1136 - (33%)

Human    11 VGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILK---ELKH 72
            ||::|:|.||::||||||||:|||||:|| :.||:|||.||...|:|.||||||||||   ||.|
  Fly     4 VGEYEYSSKDMLGHGAFAVVYKGRHRKKH-MPVAIKCITKKGQLKTQNLLGKEIKILKELTELHH 67

Human    73 ENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHR 137
            ||:|||.|.:|..:.|.|||||||||||||||....||||||:||||.|:||||:.|::|||:||
  Fly    68 ENVVALLDCKESQDCVSLVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGIVHR 132

Human   138 DLKPQNILLSNPAGRR-ANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGK 201
            ||||||||||:..|:. ..|:.|.:|||||||||:|....|||||||||||||||||||..||.|
  Fly   133 DLKPQNILLSHNYGKTLPAPSKITLKIADFGFARFLNEGAMAATLCGSPMYMAPEVIMSLQYDSK 197

Human   202 ADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDR 266
            |||||:||||||||||||||.|.:|.:|:.:||:|..|.|.||...|..||.|||.||:||.|||
  Fly   198 ADLWSLGTIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPSGVSPDLRDLLLCLLRRNSKDR 262

Human   267 MDFDEFFHHPFLD--------ASPS--------VRKSPPVPVPSYPSSGSGSSSSSSSTSHLASP 315
            :.::.||.|.||.        ..||        |.||..:||...|..|:..:.:.|........
  Fly   263 ISYESFFVHRFLQGKKAAVSPGEPSQAANLRRRVSKSGVLPVDMPPLGGTPPAKAKSPLQQQLEQ 327

Human   316 P----SLGEMQQLQK-------------TLASPADTA-----GFLHSSRDSGGSKDSSCDTDDFV 358
            .    .|.|.||.::             .:|:||..|     |.|..|.::.||..|..|:||||
  Fly   328 ELKLVKLAEQQQKEREEQEAQEDENTVSVVANPAICATITNVGVLCDSENNSGSCSSHEDSDDFV 392

Human   359 MVPAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSS---------PSP 414
            :||...|.|........:..|           ||.|.....:....|||..||         |:|
  Fly   393 LVPKNLPEDQRQGLAQVQAQP-----------ASGGQRPQQQQNQSSPPRPSSLPISEPKPVPAP 446

Human   415 S----GRAGPFSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAVHRSGRAAEASPPN 475
            :    .|.||.:.:..|..       |:...|.|......|.|.::..||.::      ..|||.
  Fly   447 ARRQVARPGPLTVATLGGQ-------QIPRSQPISVKQPRPDQRKSSVSSDIN------SISPPA 498

Human   476 ICLVFRSSAIR-RSGSTSPLGFARASPSPPAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPG 539
            :.....:...| ||.|...|     |.:||.||                   ||.
  Fly   499 VQFAIGTPPTRMRSASGGSL-----SETPPPHA-------------------PST---------- 529

Human   540 WSGTPSPQGAEMRGGRSPRPGSSAPEHSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAV 604
            |..:|....:.:|     |.|:|
  Fly   530 WQVSPGHSQSPLR-----RSGNS------------------------------------------ 547

Human   605 FSPPQASPPQPSHGLQSCRNLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALL 669
                  ||..||..|         .||          |.|||||..|       .|.|   |..:
  Fly   548 ------SPVLPSAAL---------TKL----------PTLGSPTMLV-------APGS---LGSI 577

Human   670 ARQGV--------VMTPPRNRTLPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLL 726
            ...|.        .|..||..|||:|...|..|.                             ||
  Fly   578 GSAGSGSENNNQHHMLGPRAFTLPELGATGGLHS-----------------------------LL 613

Human   727 KAAFGTQAPDPGSTESLQEKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQG 791
                     |.|               ||.||..|
  Fly   614 ---------DTG---------------AGGGGEPH------------------------------ 624

Human   792 PRTRMFSAGPTGSASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEE 856
                                                                   .|:||:|.||
  Fly   625 -------------------------------------------------------AFQAPELSEE 634

Human   857 TLMEQEHTEILRGLRFTLLFVQHVLEIA------------ALKGSASEAAGGPEYQLQESVVADQ 909
            |||::||.|.|..|.|.|.....:.|:|            |...||::||         |..|.|
  Fly   635 TLMDREHNETLSKLNFVLALTDCIQEVADSRCAPLSTFMVAGSQSAAQAA---------SADAQQ 690

Human   910 ISLLSRE-WGFAEQLVLYLKVAELLSSGLQSAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSC 973
            |...:.| ...||:|||.::..:|||||:..|..|:..|:|..||.||..:..:|..|:
  Fly   691 IPPHAPEHCKRAERLVLLVRGLQLLSSGMNLASQQLSNGQLKPSSNVKNALLTMNAKYR------ 749

Human   974 QGLSLRLQRFFLDKQRLLDRIH--SITAERLIFSHAVQMVQSAALDEMFQHREGCVPRYHKALLL 1036
               |:..:...|:...||.:.:  :|||:::::.:|:.|.|:|||||:.::.:.|..||:.|.:|
  Fly   750 ---SMLFESKRLNGSGLLQKANAFNITADKILYDYALDMCQAAALDELLKNTKNCFERYNTAHIL 811

Human  1037 LEGLQHMLSDQADIENVTKCKLCIERRLSAL 1067
            |..|....:...|...:.|.:..:|:|||.|
  Fly   812 LHSLVQKCNHPQDKMMLNKYRDAVEKRLSIL 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ULK1	XP_011537100.1	STKc_ULK1	13..279	CDD:271104	176/269 (65%)
		S_TKc	16..278	CDD:214567	174/265 (66%)
		DUF3543	860..1067	CDD:288883	67/221 (30%)
Atg1	NP_001163433.1	S_TKc	9..274	CDD:214567	174/265 (66%)
		STKc_ULK1_2-like	15..273	CDD:271022	171/258 (66%)
		DUF3543	638..844	CDD:288883	68/223 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144498
Domainoid	1	1.000	346	1.000	Domainoid score	I1044
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	485	1.000	Inparanoid score	I1451
Isobase	1	0.950	-	0	Normalized mean entropy	S3689
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	1	1.000	-	-		FOG0002616
OrthoInspector	1	1.000	-	-		otm42195
orthoMCL	1	0.900	-	-		OOG6_104561
Panther	1	1.100	-	-	O	PTHR24348
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5656
SonicParanoid	1	1.000	-	-		X1024
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740