DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIRREL2 and kirrel1

DIOPT Version :9

Sequence 1:	NP_954649.3	Gene:	KIRREL2 / 84063	HGNCID:	18816	Length:	708	Species:	Homo sapiens
Sequence 2:	XP_012808656.1	Gene:	kirrel1 / 100489692	XenbaseID:	XB-GENE-483274	Length:	754	Species:	Xenopus tropicalis

Alignment Length:	769	Identity:	271/769 - (35%)
Similarity:	378/769 - (49%)	Gaps:	119/769 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    24 PHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDL 88
            |.|:|:|.|..|:.|::..|.|.:..|.|:|||||.|||||..::|..|.||.|.||..:||::|
Frog    21 PRFIQEPTDQTVVAGQKVVLTCVVLNYSGIVQWTKDGLALGLGQNLRIWPRYQIVGNVESGQYNL 85

Human    89 HIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDAR 153
            .|....:.|:|::|||||:|.|||:.|:|.||:|||.|.:.|||.:.|.||.|.|||||: ..|:
Frog    86 EISNASIVDDANFECQATEAALRSQKAKLTVLIPPEDPVIEGGPEILLRAGTPTNLTCRA-NSAK 149

Human   154 PTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTA 218
            |...::|||||....|..:...:|.:|...:..|.|.::|...|.|..|.||..::|:|:|::|:
Frog   150 PPASIVWFRDGNQQAGDVYSTEVLADGKRATTVSYLLISPTDQDIGRVFTCRTSNEAIPSGKETS 214

Human   219 ITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADAS 283
            :.|::.:||.||||..|.||||||:|.|.|.|||.|.:.||||||||..:..||....|...|.|
Frog   215 VKLNVHHPPTVTLSIHPQTVQEGERVRFTCSATANPEIKGYRWAKGGMIIESARDSSYETQVDYS 279

Human   284 FLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRR 348
            |.||||||||.|.|||.|.||.:||.|.|.:..:|:|.:.|:|.|.:.:|.|.|||...:|||::
Frog   280 FFTEPVSCEVHNEVGSTNVSTLVDVQFAPRVVVEPKPTTTDMGSDVTLTCIWAGNPPLTLTWTKK 344

Human   349 GGAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRG 413
            |...||.:|..|.|.||..||||.|||:|.....|:  |..|..|.||.||::.:.....|....
Frog   345 GSNMVLSNGNQLFLKSVKQEDAGPYVCKAIVPRIGV--GEREVTLFVNGPPIIASEEVQYAARGD 407

Human   414 PARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESD 478
            ..:::|.:.::|.||.:.|:|.|..||.|:..|:.||       |.....|::|.|.|:...|||
Frog   408 KGKVECFIGSTPPPDRIAWAWKENVLETGTLERYTVE-------RTTSTSGVLSTLTINNVMESD 465

Human   479 FSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVAL-CCWRHSKASAS 542
            |...:||:|.|..|.|.|...|..|:::| |.|:||.......|:::..|..: ..:|..|.|..
Frog   466 FQTRYNCTAWNSFGPGTAIIQLLEREVVP-VGIIAGATIGAGILVIIFFGFFIFFLYRRRKGSRK 529

Human   543 FSEQKNL-MRIPGSSDGSSSRGP------EEEETGSREDRGPIVHTDHS--------------DL 586
            ....:.| :::.     :.:|.|      .||:|.|......::...:|              |.
Frog   530 DVTLRKLDIKVE-----TVNREPLTLHSDREEDTSSVSTATRVMKAIYSSFKDDVDLKQDLRCDT 589

Human   587 VLEEEGTLETKDPTNGYYKVR------------------------------------GVSVSLSL 615
            :..||  .|.||||||||.||                                    |.:...|.
Frog   590 IDREE--YELKDPTNGYYNVRAHDDRPNSRTVLYQDYRTTGATRFDGRPSSRLSHSSGYAQLNSF 652

Human   616 GEAPGGGLFLPPPSPLGPPGTPT----FYD----FNPHLGMVPPCRLYRARAGYLTTPHPRAFTS 672
            ..||.......|.:.:.|..|.|    .||    |..| |       :.:.:||     |.....
Frog   653 SRAPASDYSTDPTTTVTPATTDTTSQLSYDNYEKFGTH-G-------FPSSSGY-----PTFRLG 704

Human   673 YIKPTSFG----------PPDLAPGTPPFPYAAFPTPSH--------PRLQTHV 708
            |.:||:.|          |.....|...|.|    |..|        .|:||||
Frog   705 YTQPTTTGMDRGPYDTYDPVGKYTGATRFSY----TSQHSDYGQRFQQRMQTHV 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIRREL2	NP_954649.3	IG_like	30..119	CDD:214653	42/88 (48%)
		IGc2	38..106	CDD:197706	31/67 (46%)
		I-set	126..224	CDD:254352	36/97 (37%)
		Ig2_KIRREL3-like	141..223	CDD:143236	29/81 (36%)
		Cell attachment site. /evidence=ECO:0000255	149..151		0/1 (0%)
		Ig	231..306	CDD:299845	45/74 (61%)
		IG_like	234..308	CDD:214653	43/73 (59%)
		Ig	312..395	CDD:299845	34/82 (41%)
		I-set	317..395	CDD:254352	33/77 (43%)
		Ig	397..501	CDD:299845	32/103 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..601		15/76 (20%)
kirrel1	XP_012808656.1	I-set	21..116	CDD:254352	45/94 (48%)
		Ig	22..116	CDD:299845	44/93 (47%)
		I-set	123..219	CDD:254352	36/96 (38%)
		Ig	138..219	CDD:299845	29/81 (36%)
		I-set	223..304	CDD:254352	48/80 (60%)
		Ig_2	227..305	CDD:290606	46/77 (60%)
		I-set	308..389	CDD:254352	34/82 (41%)
		Ig_2	311..389	CDD:290606	33/79 (42%)
		Ig5_KIRREL3	391..487	CDD:143306	32/102 (31%)
		IG_like	399..487	CDD:214653	30/94 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG43266
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	1	1.000	-	-		FOG0001084
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1593
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930