Protein Alignment SPOP and spop

DIOPT Version :10

• Sequence 1: NP_003554.1
• Gene: SPOP / 8405
• HGNCID: 11254
• Length: 374
• Species: Homo sapiens
• Sequence 2: NP_989003.1
• Gene: spop / 394599
• XenbaseID: XB-GENE-1003310
• Length: 374
• Species: Xenopus tropicalis
• Alignment Length: 374
• Identity: 369/374 - (98%)
• Similarity: 372/374 - (99%)
• Gaps: 0/374 - (0%)

Human     1 MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKL 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog     1 MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKL 65

Human    66 KWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKD 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog    66 KWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKD 130

Human   131 WGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPECRLADELGGLWE 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   131 WGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPECRLADELGGLWE 195

Human   196 NSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYT 260
            ||||||||||||||||||||||||||||||||||||||||||||||||.||||:|||||||||||
 Frog   196 NSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIKDVEPDVFKEMMCFIYT 260

Human   261 GKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFI 325
            |||.||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||
 Frog   261 GKASNLDKMADDLLAAADKYALERLKVMCEEALCSNLSVENAAEILILADLHSADQLKTQAVDFI 325

Human   326 NYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS 374
            |||||||:|||||||||||||||||||||||||||||||||||||||||
 Frog   326 NYHASDVMETSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPOP	NP_003554.1	MATH_SPOP	28..166	CDD:239743	137/137 (100%)
		Required for nuclear localization	71..191		119/119 (100%)
		Important for binding substrate proteins	123..133		9/9 (100%)
		BTB_POZ_SPOP-like	182..301	CDD:349588	114/118 (97%)
		Important for homodimerization	186..217		30/30 (100%)
		BACK_SPOP	297..367	CDD:350593	68/69 (99%)
		Important for homodimerization	297..355		56/57 (98%)
spop	NP_989003.1	MATH_SPOP	28..166	CDD:239743	137/137 (100%)
		Required for nuclear localization. /evidence=ECO:0000250	71..191		119/119 (100%)
		BTB_POZ_SPOP-like	182..301	CDD:349588	114/118 (97%)
		BACK_SPOP	297..367	CDD:350593	68/69 (99%)
		Homodimerization. /evidence=ECO:0000250	297..355		56/57 (98%)