Protein Alignment SPOP and Spop

DIOPT Version :10

• Sequence 1: NP_003554.1
• Gene: SPOP / 8405
• HGNCID: 11254
• Length: 374
• Species: Homo sapiens
• Sequence 2: NP_079563.2
• Gene: Spop / 20747
• MGIID: 1343085
• Length: 374
• Species: Mus musculus
• Alignment Length: 374
• Identity: 374/374 - (100%)
• Similarity: 374/374 - (100%)
• Gaps: 0/374 - (0%)

Human     1 MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKL 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKL 65

Human    66 KWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKD 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 KWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKD 130

Human   131 WGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPECRLADELGGLWE 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 WGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPECRLADELGGLWE 195

Human   196 NSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYT 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 NSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYT 260

Human   261 GKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFI 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 GKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFI 325

Human   326 NYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS 374
            |||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 NYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPOP	NP_003554.1	MATH_SPOP	28..166	CDD:239743	137/137 (100%)
		Required for nuclear localization	71..191		119/119 (100%)
		Important for binding substrate proteins	123..133		9/9 (100%)
		BTB_POZ_SPOP-like	182..301	CDD:349588	118/118 (100%)
		Important for homodimerization	186..217		30/30 (100%)
		BACK_SPOP	297..367	CDD:350593	69/69 (100%)
		Important for homodimerization	297..355		57/57 (100%)
Spop	NP_079563.2	MATH_SPOP	28..166	CDD:239743	137/137 (100%)
		Required for nuclear localization. /evidence=ECO:0000250	71..191		119/119 (100%)
		Important for binding substrate proteins. /evidence=ECO:0000250	123..133		9/9 (100%)
		BTB_POZ_SPOP-like	182..301	CDD:349588	118/118 (100%)
		Important for homodimerization. /evidence=ECO:0000250	186..217		30/30 (100%)
		BACK_SPOP	297..367	CDD:350593	69/69 (100%)
		Important for homodimerization. /evidence=ECO:0000250	297..355		57/57 (100%)