Protein Alignment SPOP and spop

DIOPT Version :10

• Sequence 1: NP_003554.1
• Gene: SPOP / 8405
• HGNCID: 11254
• Length: 374
• Species: Homo sapiens
• Sequence 2: NP_957424.1
• Gene: spop / 100005514
• ZFINID: ZDB-GENE-040426-1378
• Length: 374
• Species: Danio rerio
• Alignment Length: 374
• Identity: 364/374 - (97%)
• Similarity: 370/374 - (98%)
• Gaps: 0/374 - (0%)

Human     1 MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKL 65
            |||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish     1 MSRVPSPPPPAEMTSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKL 65

Human    66 KWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKD 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish    66 KWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKD 130

Human   131 WGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPECRLADELGGLWE 195
            ||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||
Zfish   131 WGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPDCRLADELGGLWE 195

Human   196 NSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYT 260
            :||||||.||||||||||||||||||||||||||||||||||||||||||||.|||||||.||||
Zfish   196 HSRFTDCSLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEAEVFKEMMFFIYT 260

Human   261 GKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFI 325
            ||||||||||||||||||||||||||||||||||::|||||||||||||||||||||||||||||
Zfish   261 GKAPNLDKMADDLLAAADKYALERLKVMCEDALCTSLSVENAAEILILADLHSADQLKTQAVDFI 325

Human   326 NYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS 374
            |||||||:|||||||||.|||||||||||||||||||||||||||||||
Zfish   326 NYHASDVMETSGWKSMVASHPHLVAEAYRSLASAQCPFLGPPRKRLKQS 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPOP	NP_003554.1	MATH_SPOP	28..166	CDD:239743	137/137 (100%)
		Required for nuclear localization	71..191		118/119 (99%)
		Important for binding substrate proteins	123..133		9/9 (100%)
		BTB_POZ_SPOP-like	182..301	CDD:349588	111/118 (94%)
		Important for homodimerization	186..217		28/30 (93%)
		BACK_SPOP	297..367	CDD:350593	67/69 (97%)
		Important for homodimerization	297..355		55/57 (96%)
spop	NP_957424.1	MATH_SPOP	28..166	CDD:239743	137/137 (100%)
		Required for nuclear localization. /evidence=ECO:0000250	71..191		118/119 (99%)
		BTB_POZ	179..301	CDD:453885	114/121 (94%)
		BACK_SPOP	297..367	CDD:350593	67/69 (97%)
		Homodimerization. /evidence=ECO:0000250	297..355		55/57 (96%)