DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AT1G35630 and RNF167

DIOPT Version :9

Sequence 1:	NP_174800.2	Gene:	AT1G35630 / 840463	AraportID:	AT1G35630	Length:	318	Species:	Arabidopsis thaliana
Sequence 2:	NP_001357232.1	Gene:	RNF167 / 26001	HGNCID:	24544	Length:	374	Species:	Homo sapiens

Alignment Length:	342	Identity:	104/342 - (30%)
Similarity:	146/342 - (42%)	Gaps:	76/342 - (22%)

- Green bases have known domain annotations that are detailed below.

plant    28 NTILSFDDVEATFTPIVRNSGECGILYVAEPLEACSDITNMAEKRSKYRSSYVLIVLG--GCSFE 90
            |..:.|.|:.|.|...:...|..|.|..|.|..|||.|.  ....:....|..:.:|.  .|:|:
Human    33 NASMDFADLPALFGATLSQEGLQGFLVEAHPDNACSPIA--PPPPAPVNGSVFIALLRRFDCNFD 95

plant    91 EKVRKAQKAGYKAAIVYNDGYDELLVPMAGNSSGVD----IHGLLVTRASGEVLKG-YADQDEMK 150
            .||..||||||.||:|:|...:||| .|..||..:.    |..:.:...|.|.|:. :..:...:
Human    96 LKVLNAQKAGYGAAVVHNVNSNELL-NMVWNSEEIQQQIWIPSVFIGERSSEYLRALFVYEKGAR 159

plant   151 LWLIPG--FGISSWSI--MGITFISLLAMSAI-LATCFVVRRHQIRQSVRDLPHGGQGLSCMPRD 210
            :.|:|.  |.:..:.|  .||..:.:|||.|: :|.|...|:...|..             :.::
Human   160 VLLVPDNTFPLGYYLIPFTGIVGLLVLAMGAVMIARCIQHRKRLQRNR-------------LTKE 211

plant   211 LLQSMPTEVYSGVLEE--------------SSTSV------TCAICIDDYCVGEKLRILPCKHKY 255
            .|:.:||..|...|..              |||..      .||||:|:|..|:|||:|||.|.|
Human   212 QLKQIPTHDYQKALNSSMFCPDLILPTCLISSTGFVGDQYDVCAICLDEYEDGDKLRVLPCAHAY 276

plant   256 HAVCIDSWLGRCRSFCPVCKQ------------------------NPRTGNDVPPASETTPLISP 296
            |:.|:|.||.:.|..||:|||                        .||.    .||||.|||:..
Human   277 HSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEGDEGEPRD----HPASERTPLLGS 337

plant   297 SPNSITSLQSFYDLPIV 313
            ||...||..|....|:|
Human   338 SPTLPTSFGSLAPAPLV 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AT1G35630	NP_174800.2	PA_C_RZF_like	11..155	CDD:239038	41/133 (31%)
AT1G35630	NP_174800.2	zf-RING_2	232..275	CDD:290367	23/42 (55%)
RNF167	NP_001357232.1	PA_C_RZF_like	20..170	CDD:239038	43/139 (31%)
		RING-H2_RNF167	252..297	CDD:319711	24/44 (55%)
		RING-H2 finger (C3H2C3-type)	254..295	CDD:319711	23/40 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	71	1.000	Domainoid score	I4059
eggNOG	1	0.900	-	-		E1_KOG4628
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I2220
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0001489
OrthoInspector	1	1.000	-	-		mtm1436
orthoMCL	1	0.900	-	-		OOG6_103040
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X670
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.730