Protein Alignment SPNS1 and TNA1

DIOPT Version :10

• Sequence 1: XP_047290695.1
• Gene: SPNS1 / 83985
• HGNCID: 30621
• Length: 586
• Species: Homo sapiens
• Sequence 2: NP_011776.1
• Gene: TNA1 / 853175
• SGDID: S000003492
• Length: 534
• Species: Saccharomyces cerevisiae
• Alignment Length: 524
• Identity: 102/524 - (19%)
• Similarity: 181/524 - (34%)
• Gaps: 163/524 - (31%)

Human    45 TMAGSDTAP--FLSQADDPDDGPVPGTPGLPGSTGNPKSE---EPEV----PDQEGLQRITGLSP 100
            |..||:..|  ...|.|:..|.      .|...:.:.|||   |.|:    .|.:|:.     ||
Yeast    23 TNDGSEEKPTEVTFQEDEGHDA------SLHNRSHDKKSELATEREIMATTTDDDGIP-----SP 76

Human   101 GR----------SALIVAVLCYINLLNYMDRFT-----VAGVLPDIEQFFNIGDSSSGLIQTVFI 150
            ..          ...::.::..:..|:.:|:..     |||:..||..   :|...:..: |||.
Yeast    77 SHPMEKRVLRKMDIYLIPLMGMLYFLSNLDKSNIGNAEVAGLSKDIHL---VGTQYNTCV-TVFF 137

Human   151 SSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTI 215
            ::|::..|:...|........:|...:..:..::||::::  :::..|::.|.|:|..|   ..|
Yeast   138 ATYVLFDPIGTNLLKIMGPPLMMSICLTCFGAISLGTAWV--KNYAQLIVVRLLLGAFE---GMI 197

Human   216 APTLIADLFVADQRSRMLSIFYF---AIPVGSGLGYIAG---SKVKDMAGDWHWALRVTPG---L 271
            .|.:...|.|..:|.:....|.|   |..:.|..|.:..   ||:.....||.: :.:..|   |
Yeast   198 YPAINMYLSVCYRREQYALRFAFVFSAACLSSSFGGLIAYGCSKISGSLKDWQY-IYIVEGCISL 261

Human   272 GVVAVLLL---------FLVVREPPRGAVERHSDLPPLNPTS-------W--------WADLRAL 312
            |.|.....         :...:|......||:..:...:|..       |        ||...||
Yeast   262 GFVPFYAFGLSKNLEDSWFFNKEEKEYISERYKTMNTFDPDEKFEWFQVWQAVKDVKTWASAVAL 326

Human   313 ARNPSF---------------VLSSLGFTAVA---------FVTGSL----ALWAPAFLLRSRVV 349
                 |               :::|:|||.|.         |:|..:    |:|:....|||..:
Yeast   327 -----FGIDLTTFGLTVFLPIIITSMGFTNVRAQLMTVPIYFLTAIVFFICAVWSDRIKLRSPFI 386

Human   350 LGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVG--LGVEISRRLRHSNPRADPLVCATGLLGSA 412
            ||                      .|||..:|:.  ||.::     |........:...|
Yeast   387 LG----------------------ACLTTSIGIAIVLGSQV-----HGVRYFGVYILCMG----- 419

Human   413 PFLFLSLAC-------------ARGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAE 464
              ::::.||             .|.:.:...:|...|..|:|....:..|...|:   ...|.:.
Yeast   420 --IYVNAACNCLWLSGNTGNYFKRATALGINLFFGSGSGLVSGQIFVAKDKPRYI---KGLSISL 479

Human   465 AFQI 468
            |||:
Yeast   480 AFQV 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPNS1	XP_047290695.1	MFS_spinster_like	107..499	CDD:340886	85/443 (19%)
TNA1	NP_011776.1	MFS_FEN2_like	87..490	CDD:340885	85/449 (19%)