Protein Alignment SPNS1 and tna1

DIOPT Version :10

• Sequence 1: XP_047290695.1
• Gene: SPNS1 / 83985
• HGNCID: 30621
• Length: 586
• Species: Homo sapiens
• Sequence 2: NP_593504.1
• Gene: tna1 / 2543262
• PomBaseID: SPAC1002.16C
• Length: 499
• Species: Schizosaccharomyces pombe
• Alignment Length: 442
• Identity: 98/442 - (22%)
• Similarity: 170/442 - (38%)
• Gaps: 124/442 - (28%)

Human   102 RSALIVA-VLCYINLLNYMDRFT-----VAGVLPDI----EQFFNIGDSSSGLIQTVFISSYMVL 156
            |..|::| .:..:.|:.::||..     |||:..|:    :||        .:|.:||..::::.
pombe    54 RLDLVLAPTIMILYLVAFLDRSNIGNAKVAGLPEDLKLKGDQF--------NIIASVFYVTFILF 110

Human   157 APVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEAS---------- 211
            ......|..:...|.::...:..:||.|:.:.|.  .:|..||..|.::|..||.
pombe   111 EMPTTLLMKKVQPKRMLAFIVISYSLTTIFTGFC--HNFGGLLAARLVLGFCEAGLFPCLALYLT 173

Human   212 --YSTI--APTLIADLFVADQRSRML-SIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGL 271
              ||.:  ||. ||.||.:...|... .:|.:|:....|:|..||         |.|...:...:
pombe   174 MIYSRVELAPR-IAYLFASSALSGAFGGLFAYAVLHMDGVGGFAG---------WRWLFIIEGLI 228

Human   272 GVVAVLLLFLVVREPPRGA---------------VERHSDLPPLN---------PTSWWADLRAL 312
            |.|..:.::.::......|               :||.:||...:         .|.:...|.||
pombe   229 GFVCGVAVYFIIPNDITKAWFLSKTHQEMMRKRQLERAADLEAAHFDWKGVKSAFTDFKVYLYAL 293

Human   313 AR-------------NPSFVLSSLGFTAVA--------FVTGSLALWAPAFL---LRSR---VVL 350
            :.             .|: ::|.:|:|:::        ::.|:....|.:||   ...|   :::
pombe   294 SEFGQDTCLYGFSTFLPA-IISGMGYTSLSVQYMTIPVYILGAATYIAASFLSDRFHHRGIILII 357

Human   351 GETPPCLPGD----SCSSSDS-LIFGLITCLTGV-LGVGLGVE-ISRRLRHSNPRADPLVCATGL 408
            |...| :.|.    :|.::.| |.|....|..|| .|.||.|. :|..:.....||..
pombe   358 GNIFP-IVGYILLLACQNNKSVLYFACYLCSVGVYTGAGLNVTWLSANIAPHYKRATA------- 414

Human   409 LGSAPFLFLSLACARGS-IVATYIF----IFIGETLLSMNWAIVADILLYVV 455
                  :.|.||.|..| |:|..|:    .:|...|.|: .||....:|:||
pombe   415 ------ISLQLAIANSSGILAGQIYRYPPKYIAGHLTSL-IAIFISTVLHVV 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPNS1	XP_047290695.1	MFS_spinster_like	107..499	CDD:340886	96/437 (22%)
tna1	NP_593504.1	MFS_FEN2_like	54..458	CDD:340885	96/439 (22%)