Protein Alignment SPNS1 and spin-1

DIOPT Version :10

• Sequence 1: XP_047290695.1
• Gene: SPNS1 / 83985
• HGNCID: 30621
• Length: 586
• Species: Homo sapiens
• Sequence 2: NP_506041.1
• Gene: spin-1 / 179662
• WormBaseID: WBGene00007549
• Length: 531
• Species: Caenorhabditis elegans
• Alignment Length: 490
• Identity: 194/490 - (39%)
• Similarity: 273/490 - (55%)
• Gaps: 58/490 - (11%)

Human    29 VGSSVGP-------ERGRARPPGTMAGSDTAPFLSQADDPDDGPVPGTPGLPGSTGNPKSEEPEV 86
            |.:.|.|       :|....||         |:.:..|.|:|      .....||....|:
 Worm     2 VRNKVAPVEDGANIQRNFEPPP---------PYTTPTDSPED------KIRSNSTATTASQ---- 47

Human    87 PDQEGLQRITGLSPGRSALIVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFIS 151
            |:.:|...|         ::||:|..|||||||||:|:||||.|::.::||.|:.:|||||.|:.
 Worm    48 PEFQGCWTI---------VVVAILFIINLLNYMDRYTIAGVLNDVQTYYNISDAWAGLIQTTFMV 103

Human   152 SYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIA 216
            .:::.:|:.|:||||||||::...|||.|......|:|||...|||.||.||:||:|||||:.|:
 Worm   104 FFIIFSPICGFLGDRYNRKWIFVVGIAIWVSAVFASTFIPSNQFWLFLLFRGIVGIGEASYAIIS 168

Human   217 PTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFL 281
            ||:|||:|....|||||.:||||||.|.|||::.||.|....|.|.|.:|||..||:|.:||:.:
 Worm   169 PTVIADMFTGVLRSRMLMVFYFAIPFGCGLGFVVGSAVASWTGHWQWGVRVTGVLGIVCLLLIIV 233

Human   282 VVREPPRGAVERHSD--LPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAP---- 340
            .||||.||..||...  ......||:..|::.|..|.::|.||||:||..|:.|:||.|||
 Worm   234 FVREPERGKAEREKGEIAASTEATSYLDDMKDLLSNATYVTSSLGYTATVFMVGTLAWWAPITIQ 298

Human   341 -AFLLRSRVVLGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVGLGVEISRR-------LRH-SN 396
             |...|....:.|..        .::.:|:||.:||:.|||||.:|..:|..       .:| ..
 Worm   299 YADSARRNGTITEDQ--------KANINLVFGALTCVGGVLGVAIGTLVSNMWSRGVGPFKHIQT 355

Human   397 PRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRS 461
            .|||.||||.|.....|.|.|::.....::...:..:||.....|.|||...|:||.||:|.|||
 Worm   356 VRADALVCAIGAAICIPTLILAIQNIESNMNFAWGMLFICIVASSFNWATNVDLLLSVVVPQRRS 420

Human   462 TAEAFQIVLSHLLGDAGSPYLIGLACCTKQGPQTT 496
            :|.::||::||:.|||..||::||.....:|.:.|
 Worm   421 SASSWQILISHMFGDASGPYILGLISDAIRGNEDT 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPNS1	XP_047290695.1	MFS_spinster_like	107..499	CDD:340886	178/405 (44%)
spin-1	NP_506041.1	MFS_spinster_like	59..482	CDD:340886	178/405 (44%)