Protein Alignment PLA2G6 and pla2g6

DIOPT Version :10

• Sequence 1: NP_003551.2
• Gene: PLA2G6 / 8398
• HGNCID: 9039
• Length: 806
• Species: Homo sapiens
• Sequence 2: XP_012816940.2
• Gene: pla2g6 / 780118
• XenbaseID: XB-GENE-920447
• Length: 801
• Species: Xenopus tropicalis
• Alignment Length: 810
• Identity: 467/810 - (57%)
• Similarity: 612/810 - (75%)
• Gaps: 13/810 - (1%)

Human     1 MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNS 65
            |..|||:.||.|.||||||||::|:||.:::|.:...::|:|:::|::|...::.|||||||.:.
 Frog     1 MDLFGRIFNTVSAVTNLFSNPYKVREVPLSEYGNCSCIQEDGRVLLYRNRTAKSLDCVLVNPISP 65

Human    66 QSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELG 130
            |:.:|||||:.|.:||:.|.:|:.:|.||||||.:.|..|.:|.|||.||:||:||:||:||::|
 Frog    66 QNAYRLFQLDSEHEALLRFQEYAVKLRPFYESSRKGLRLETIQQLTDCIRSHPNWSLAHVAVDIG 130

Human   131 IRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQ 195
            :||.|.|:.|:...|..:.:.|.|||||||:|||.|.|.|||:.|..:.|:.|..||||:|:|.|
 Frog   131 LRESFKHNGILRSLNSTDCDGGSTPLHLACKKGDIECLQELVEECQARQDIADQNGETVYHHAAQ 195

Human   196 GDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAM 260
            .:|.:|:::|......|:|..:|....|||:||::||.|.|..||.|.|||:|:|.:|||||:||
 Frog   196 QNNPRVIEILCSVPSVGINHQSNNNEAPLHVACRMGKTESVLALLRCQARCDIIGKDGYPIHTAM 260

Human   261 KFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAV 325
            |:||.||||.|:.:.::|:|::||||.|:|:||||||||||:|::|||.||:.|...:|.||:.|
 Frog   261 KYSQNGCAEAILDVSANQLHAEDPRYQATPIHWAKNAEMARLLIQRGCKVNTRSKTSDTPLHIMV 325

Human   326 MRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLA 390
            .|:||:.|:||||:||:.:|:||||||||||||.||::|:||||:||||:|:..|||||||..:|
 Frog   326 KRDRFEAAMVLLTNGADPNAKGEHGNTPLHLAMKKDHLELIKALMVFGADVEQHNDFGETPGLIA 390

Human   391 SKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLM 455
            ::..:...||.:|::|..||||.|.|     |..|.......|.|:    ||....:.:...||:
 Frog   391 ARSSKGNNRKVLLSMLCNVGAERCLP-----PDTQLLPTATSPSSV----PPSDRSSGIGFHDLV 446

Human   456 HISRARK----PAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVA 516
            ::|.|..    |...:....|..|..|.||||||||::||::||||||||||:|...::|||||:
 Frog   447 YVSTALSGMLVPQDTVDFREDGLRVKDRLLCLDGGGIRGLVLIQLLIAIEKAAGRPIRELFDWVS 511

Human   517 GTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPK 581
            ||||||||||||:|...|.|:|.:|||||:|||.||||||||||||||||||||:|||:|||.||
 Frog   512 GTSTGGILALAIVHGMPMEYVRCLYFRMKNEVFHGSRPYESGPLEEFLKREFGENTKMSDVRNPK 576

Human   582 VMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRP 646
            |::|||||||.|||||||||||.|||..||.:....:.||...|::||||||||||||||||.||
 Frog   577 VIVTGTLSDRHPAELHLFRNYDPPETDHEPPYKSVASFRPVTAPAEQLVWRAARSSGAAPTYLRP 641

Human   647 NGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRP 711
            .|||||||||:||||||||||:|:||..|.:||.|.:||||.||||||||:.||:.|:.||||||
 Frog   642 MGRFLDGGLLSNNPTLDAMTEMHQYNNCLKKKGMAGQVKKLGIVVSLGTGKPPQISVSSVDVFRP 706

Human   712 SNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDT 776
            |||||:.|||.||:||||||||||||.||.||.||||||||:.:.||||:|||.||:|||||:|.
 Frog   707 SNPWEMMKTVVGARELGKMVVDCCTDSDGPAVSRARAWCEMIDVPYFRLSPQLQTDVMLDEVNDA 771

Human   777 VLVNALWETEVYIYEHREEFQKLIQLLLSP 806
            ||||.||:|::|||:.||..|:|.::||.|
 Frog   772 VLVNMLWDTQIYIYQQREVLQRLAKILLEP 801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLA2G6	NP_003551.2	ANKYR	105..407	CDD:440430	161/301 (53%)
		ANK repeat	118..149	CDD:293786	14/30 (47%)
		ANK 1. /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8	120..147		13/26 (50%)
		ANK repeat	151..183	CDD:293786	18/31 (58%)
		ANK 1. /evidence=ECO:0000255	151..181		17/29 (59%)
		ANK repeat	185..217	CDD:293786	12/31 (39%)
		ANK 2. /evidence=ECO:0000255	185..215		11/29 (38%)
		ANK repeat	219..248	CDD:293786	15/28 (54%)
		ANK 3. /evidence=ECO:0000255	219..248		15/28 (54%)
		ANK 4. /evidence=ECO:0000255	251..281		16/29 (55%)
		ANK repeat	286..314	CDD:293786	19/27 (70%)
		ANK 5. /evidence=ECO:0000255	286..312		18/25 (72%)
		ANK repeat	316..347	CDD:293786	15/30 (50%)
		ANK 6. /evidence=ECO:0000255	316..345		14/28 (50%)
		ANK repeat	349..380	CDD:293786	22/30 (73%)
		ANK 7. /evidence=ECO:0000255	349..378		22/28 (79%)
		ANK 9. /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8	382..403		8/20 (40%)
		Pat_PNPLA9	480..793	CDD:132851	229/312 (73%)
		GXGXXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	485..490		3/4 (75%)
		GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	517..521		3/3 (100%)
		DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	652..654		1/1 (100%)
		Calmodulin-binding (1-9-14 motif). /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8	677..686		4/8 (50%)
		Calmodulin-binding (IQ motif). /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8	748..759		6/10 (60%)
pla2g6	XP_012816940.2	ANKYR	136..403	CDD:440430	141/266 (53%)
		ANK repeat	152..183	CDD:293786	18/30 (60%)
		ANK repeat	185..217	CDD:293786	12/31 (39%)
		ANK repeat	219..244	CDD:293786	12/24 (50%)
		ANK repeat	255..283	CDD:293786	15/27 (56%)
		ANK repeat	316..347	CDD:293786	15/30 (50%)
		ANK repeat	349..377	CDD:293786	21/27 (78%)
		ANK repeat	382..411	CDD:293786	11/28 (39%)
		Pat_PNPLA9	475..788	CDD:132851	229/312 (73%)