Protein Alignment PLA2G6 and Pla2g6

DIOPT Version :10

• Sequence 1: NP_003551.2
• Gene: PLA2G6 / 8398
• HGNCID: 9039
• Length: 806
• Species: Homo sapiens
• Sequence 2: XP_036015396.1
• Gene: Pla2g6 / 53357
• MGIID: 1859152
• Length: 953
• Species: Mus musculus
• Alignment Length: 953
• Identity: 724/953 - (75%)
• Similarity: 762/953 - (79%)
• Gaps: 147/953 - (15%)

Human     1 MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNS 65
            ||||||||||.|.||||||||||||||::.||.||:||||||||||.||..|||||||||:|||.
Mouse     1 MQFFGRLVNTLSSVTNLFSNPFRVKEVSLTDYVSSERVREEGQLILLQNVSNRTWDCVLVSPRNP 65

Human    66 QSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELG 130
            ||||||||||.||||||||.|:||||.||||||.||||.||||||||||||||||:|.|||||||
Mouse    66 QSGFRLFQLESEADALVNFQQFSSQLPPFYESSVQVLHVEVLQHLTDLIRNHPSWTVTHLAVELG 130

Human   131 IRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQ 195
            |||||||||||||||..|||||||||||||||||.|||||||||||.||||||.||||.||||||
Mouse   131 IRECFHHSRIISCANSTENEEGCTPLHLACRKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQ 195

Human   196 GDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAM 260
            |||.|||||||:||.||||||||||||||||||::|||||||||||||||||||||.|:|||:||
Mouse   196 GDNPQVLQLLGKNASAGLNQVNNQGLTPLHLACKMGKQEMVRVLLLCNARCNIMGPGGFPIHTAM 260

Human   261 KFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAV 325
            ||||||||||||||||:|||||||||||||||||||||||||||||||:|:||||:|||||||||
Mouse   261 KFSQKGCAEMIISMDSNQIHSKDPRYGASPLHWAKNAEMARMLLKRGCDVDSTSSSGNTALHVAV 325

Human   326 MRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLA 390
            |||||||.:||||:||||.||||||||||||||||||:||:||||||||||||||||||||..:|
Mouse   326 MRNRFDCVMVLLTYGANAGARGEHGNTPLHLAMSKDNMEMVKALIVFGAEVDTPNDFGETPALIA 390

Human   391 SKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHP-FSLERAQPPPISLNNLELQDL 454
            |||.:|:||||:||||:||||::.||.|.||..||||||..|| |||:|.|||.|||||||||||
Mouse   391 SKISKLITRKALLTLLKTVGADHHFPIIQGVSTEQGSAAATHPLFSLDRTQPPAISLNNLELQDL 455

Human   455 MHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTS 519
            |.|||||||||||.|||||||:|||||||||||||||:|||||||||||||||||||||||||||
Mouse   456 MPISRARKPAFILSSMRDEKRSHDHLLCLDGGGVKGLVIIQLLIAIEKASGVATKDLFDWVAGTS 520

Human   520 TGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVML 584
            ||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||:||||||
Mouse   521 TGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVKKPKVML 585

Human   585 TGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGR 649
            ||||||||||||||||||||||.|||||.|||:||:||.||:|||||||||||||||||||||||
Mouse   586 TGTLSDRQPAELHLFRNYDAPEAVREPRCNQNINLKPPTQPADQLVWRAARSSGAAPTYFRPNGR 650

Human   650 FLDGGLLANNPTLDAMTEIHEYNQDLIRK------------------------------------ 678
            |||||||||||||||||||||||||:|||
Mouse   651 FLDGGLLANNPTLDAMTEIHEYNQDMIRKLPQGAAAGPGQDGTWVCSCCSCCSCCSCCSCCSCSC 715

Human   679 ----------------------------------------------------------------- 678
                                                                             
Mouse   716 CCCCSCCSCCSCCCCCSCCSCCSCCSCCSCCCCCSCCSCCCCCSCCSCCSCCSCCCSCCSCSCSC 780

Human   679 ---------------------------------------------GQANKVKKLSIVVSLGTGRS 698
                                                         ||.|||||||||||||||:|
Mouse   781 SYSLSYSRSRVLSVPHSPLPSLGPVLTPIPTCGKSSLTTLSCSSQGQGNKVKKLSIVVSLGTGKS 845

Human   699 PQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQ 763
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   846 PQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQ 910

Human   764 LGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP 806
            ||:|||||||||.|||||||||||||||||||||||:||||||
Mouse   911 LGSDIMLDEVSDAVLVNALWETEVYIYEHREEFQKLVQLLLSP 953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLA2G6	NP_003551.2	ANKYR	105..407	CDD:440430	268/301 (89%)
		ANK repeat	118..149	CDD:293786	26/30 (87%)
		ANK 1. /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8	120..147		24/26 (92%)
		ANK repeat	151..183	CDD:293786	29/31 (94%)
		ANK 1. /evidence=ECO:0000255	151..181		27/29 (93%)
		ANK repeat	185..217	CDD:293786	27/31 (87%)
		ANK 2. /evidence=ECO:0000255	185..215		25/29 (86%)
		ANK repeat	219..248	CDD:293786	26/28 (93%)
		ANK 3. /evidence=ECO:0000255	219..248		26/28 (93%)
		ANK 4. /evidence=ECO:0000255	251..281		25/29 (86%)
		ANK repeat	286..314	CDD:293786	25/27 (93%)
		ANK 5. /evidence=ECO:0000255	286..312		24/25 (96%)
		ANK repeat	316..347	CDD:293786	25/30 (83%)
		ANK 6. /evidence=ECO:0000255	316..345		24/28 (86%)
		ANK repeat	349..380	CDD:293786	28/30 (93%)
		ANK 7. /evidence=ECO:0000255	349..378		26/28 (93%)
		ANK 9. /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8	382..403		14/20 (70%)
		Pat_PNPLA9	480..793	CDD:132851	298/458 (65%)
		GXGXXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	485..490		4/4 (100%)
		GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	517..521		3/3 (100%)
		DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	652..654		1/1 (100%)
		Calmodulin-binding (1-9-14 motif). /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8	677..686		7/154 (5%)
		Calmodulin-binding (IQ motif). /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8	748..759		10/10 (100%)
Pla2g6	XP_036015396.1	ANKYR	102..407	CDD:440430	270/304 (89%)
		ANK repeat	119..149	CDD:293786	25/29 (86%)
		ANK repeat	151..183	CDD:293786	29/31 (94%)
		ANK repeat	185..217	CDD:293786	27/31 (87%)
		ANK repeat	219..248	CDD:293786	26/28 (93%)
		ANK repeat	286..314	CDD:293786	25/27 (93%)
		ANK repeat	316..347	CDD:293786	25/30 (83%)
		ANK repeat	349..380	CDD:293786	28/30 (93%)
		Pat_PNPLA9	481..940	CDD:132851	298/458 (65%)