DRSC/TRiP Functional Genomics Resources

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Protein Alignment PLA2G6 and mask

DIOPT Version :10

Sequence 1:NP_003551.2 Gene:PLA2G6 / 8398 HGNCID:9039 Length:806 Species:Homo sapiens
Sequence 2:NP_001247280.1 Gene:mask / 50070 FlyBaseID:FBgn0043884 Length:4010 Species:Drosophila melanogaster


Alignment Length:1292 Identity:216/1292 - (16%)
Similarity:382/1292 - (29%) Gaps:517/1292 - (40%)


- Green bases have known domain annotations that are detailed below.


Human   383 LEECTSPTDHSDSASVHDM-DYVNPRGVRFTQSSQKEGTALVPYGL---------PCIRELFRFL 437
            :..|:|.:.:|.:.|:..: |:.|.:|::  |..|::.......|.         .||...:..:
  Fly     1 MSSCSSTSIYSSTHSLTSICDHQNQQGLQ--QQYQQQHHQYQCSGSCRCKAFGNEQCIESFYECM 63

Human   438 ISLTNPHDRHNSEVMIHM--GLHLLTVALESAPVAQCQTLLGLIKDEMCRHLFQLLSVERLNLYA 500
            :...:|:.:.|    ||.  |..:..:......|..||               |....|.:|.:.
  Fly    64 LHPGSPNKKEN----IHKTHGQTMQNIRKSCPNVIYCQ---------------QQQQYENINSFG 109

Human   501 ASLRVCFLLFESMREHLKFQLEMYIKKLMEIITVE---------NPKMPYEMKEMALEAI----- 551
            :. .||  :..:..:.....:...:..|..:.|:.         |...|.:..:..:|:.     
  Fly   110 SD-AVC--VERNKNQGASITIAKVVNPLGTVTTISTVGTRSITPNSIKPDDFMQECIESYLHENC 171

Human   552 ---------------VQLWRIPSFVTELYINYDCDYY--------CSN---------LFEDLTKL 584
                           ||..:||:...::..|....|:        ||:         :|....:.
  Fly   172 DEALFRPVVTVHYDNVQSRKIPTQEIDMMENRSNIYHDTSINSIECSSVDSCDKGKFMFRGNEEQ 236

Human   585 LSKNAFPVSGQLYT-----THLLSLDALLTVIDSTEAHCQAKVLN----TLNQQEKKETARPGFE 640
            ..::||.|...|..     .:|.||.::..:......|.|.:..|    ..|..||..|.:....
  Fly   237 SKQSAFLVEPDLIVPVIEEKNLSSLSSVTAIRQQDSKHEQLRDSNIEILKKNMHEKFNTRKKSLT 301

Human   641 AVDGSPD-TYKSERAASDGKATGVPSDAPGLHFSSGGWLSTEHGKPGCSDLEEAGDSGVDKKTTR 704
            .:|.:.| .::|||:.| |||                          |.:.|..           
  Fly   302 KIDDTKDLKFESERSDS-GKA--------------------------CDEFENI----------- 328

Human   705 KPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLREN 769
            :.|:   |..:|..:.|...||:...:..|:.:......|:.|.:|.|::               
  Fly   329 ELPK---LCNNPLRINESILKKERRDSLKEEKDIYDDSKIESLTKKLLIS--------------- 375

Human   770 PRLDKKMIGEFVSDRKNMDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIHRLLEVFTEH 834
                 |.||...:.:|::.:|..     |.:.:.:|..||..|:.|   |.:.|           
  Fly   376 -----KNIGSTKTRKKSLPVLVD-----SHKLVNVDRKLRRDLDNF---GNSAV----------- 416

Human   835 WRSCNGSPFANSDACFALAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILE 899
                                        .|..|:...|.....:|:  ||..:| .|.|.||.  
  Fly   417 ----------------------------HHIKNIISSNKTSDKQEY--NLVSLN-QKGFTQDT-- 448

Human   900 DMYHAIKNEEIVMPEEQTGLVRENYVWSVLL-HRGATPEGIFLRVPPGSYDLDLFTMTWGPTIAA 963
               .::|| |::.|......       |||: |....|....|::.    |::||....|.....
  Fly   449 ---QSVKN-ELINPISDAPP-------SVLMYHECLLPSLESLKID----DIELFGEDSGQQTTE 498

Human   964 LS---------YVFDK-------SLEETII--------------QKAISGFRKCAMISAHY---- 994
            .|         .|.||       |....||              :|..||......:..:|    
  Fly   499 QSTDNSNARDTSVIDKDGSKSEYSESSNIIAKNQKMKEEKTSNEEKETSGIVTTPDLDNYYDPVN 563

Human   995 --------GLSDVFDNLI-----ISLCKFTALSSESIENLPSVFGSNPKAHIAAKTVFHLAHRHG 1046
                    |.:|....::     |..|   |:..::.||.        ..|...:..|.:.    
  Fly   564 NDQRYKMLGYTDCSQTVVQLNDNIDKC---AMDDKNDENF--------DVHQLNQLKFDMQ---- 613

Human  1047 DILREGWKNIMEAMLQLFRAQLLPKAMVEVEDFVDPNGKISLQREETPSNRGESTVLSFVSWLTL 1111
            ::|..|  |||.||....|         ||.:.:|          ..|||..:||          
  Fly   614 EVLSRG--NIMLAMCSSLR---------EVSESID----------TYPSNSSDST---------- 647

Human  1112 SGPEQSSVRGPSTENQEAKRVALDCIKQCDPEKMITESKFLQLESLQELMKALVSVTPDEETYDE 1176
                    |...:||       .:.:.:||....:.....|.|:.              ..||::
  Fly   648 --------RKEQSEN-------FNNLNECDANYSLFSENELGLKK--------------RATYEK 683

Human  1177 EDAAFCLEMLLRIVLENRDRVGCVWQTVRDHLYHLCVQAQDFCFLVERA--VVGLLRLAIRLLRR 1239
            :                          |....:|..         .|.|  :||||..|...:..
  Fly   684 Q--------------------------VTSPFHHPS---------TEHATPLVGLLFSASEKISD 713

Human  1240 EEISGQVLLSLRILLLMKPSVLSRVSHQVAYGLHELLKTNAANIHSG-DDWA-------TLFTLL 1296
            ::::..::                              .|..:..:| ||.|       |::|.:
  Fly   714 DDVTDNLI------------------------------NNDQDKETGHDDVALTKKKTKTMYTFI 748

Human  1297 ECIGSGVKPPDALQATARADAPDAGAQSDSELPSYHQNDVSLDRGYTSDSEVYTDHGRPGKMHRS 1361
            |                          .|.::..:|..:.||... .|.|.:.|..|.|      
  Fly   749 E--------------------------PDDKVRRWHYPNNSLSNN-KSTSIIMTTMGDP------ 780

Human  1362 ATDADMANSGWLVVGKDDIDNSKPAAGLSRPGPSPLVNQYSLTVGLDLGPHDTKSLLKCVESLSF 1426
                        .|..||.|..:                       |.|....:.|:...::.|:
  Fly   781 ------------EVDSDDEDEKR-----------------------DEGDDGLEPLIAFQKTSSY 810

Human  1427 IVRDAAHITPDNF-------------ELCVKTLRIFVEASLNGGC-KSQDKRGKSHKYDS----K 1473
            ::.|..:|..:|:             |:.|....:.:|   |..| :.::.:...|..||    .
  Fly   811 LISDTTNIENNNYSTSSEGSLLGIQNEMSVSMAALPIE---NVRCVQGKEFQEPVHVSDSAESVN 872

Human  1474 GNRFKKKP----KEGSMLRRPRASSQHATRAGHSDEEEDEGVPASYHTVSLQVSQDL 1526
            .||.:.:|    .:.|.:    ||||......:|....|..:.||  :::.:.:.|:
  Fly   873 YNRIRTEPTVALDDDSTI----ASSQSLIPNSNSSSNLDTSLIAS--SITTKTTSDV 923

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLA2G6NP_003551.2 ANKYR 105..407 CDD:440430 6/24 (25%)
ANK repeat 118..149 CDD:293786
ANK 1. /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8 120..147
ANK repeat 151..183 CDD:293786
ANK 1. /evidence=ECO:0000255 151..181
ANK repeat 185..217 CDD:293786
ANK 2. /evidence=ECO:0000255 185..215
ANK repeat 219..248 CDD:293786
ANK 3. /evidence=ECO:0000255 219..248
ANK 4. /evidence=ECO:0000255 251..281
ANK repeat 286..314 CDD:293786
ANK 5. /evidence=ECO:0000255 286..312
ANK repeat 316..347 CDD:293786
ANK 6. /evidence=ECO:0000255 316..345
ANK repeat 349..380 CDD:293786
ANK 7. /evidence=ECO:0000255 349..378
ANK 9. /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8 382..403 4/20 (20%)
Pat_PNPLA9 480..793 CDD:132851 60/368 (16%)
GXGXXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161 485..490 0/4 (0%)
GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161 517..521 0/3 (0%)
DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161 652..654 1/1 (100%)
Calmodulin-binding (1-9-14 motif). /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8 677..686 0/8 (0%)
Calmodulin-binding (IQ motif). /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8 748..759 2/10 (20%)
maskNP_001247280.1 ANKYR 584..858 CDD:440430 74/484 (15%)
ANK repeat 596..628 CDD:293786 11/45 (24%)
ANK repeat 633..661 CDD:293786 9/62 (15%)
ANK repeat 663..694 CDD:293786 6/79 (8%)
ANK repeat 696..724 CDD:293786 6/57 (11%)
ANK repeat 730..760 CDD:293786 9/55 (16%)
ANKYR 744..1062 CDD:440430 43/257 (17%)
ANK repeat 765..794 CDD:293786 10/70 (14%)
ANK repeat 796..827 CDD:293786 5/30 (17%)
ANK repeat 829..858 CDD:293786 5/31 (16%)
ANK repeat 862..894 CDD:293786 9/35 (26%)
ANK repeat 896..923 CDD:293786 4/28 (14%)
ANK repeat 927..957 CDD:293786
ANK repeat 959..991 CDD:293786
ANK repeat 993..1023 CDD:293786
ANK 2321..2349 CDD:197603
ANK repeat 2323..2352 CDD:293786
ANKYR 2336..2623 CDD:440430
ANK repeat 2354..2386 CDD:293786
ANK repeat 2390..2419 CDD:293786
ANK repeat 2421..2452 CDD:293786
ANK repeat 2456..2486 CDD:293786
ANK repeat 2492..2521 CDD:293786
ANK repeat 2523..2589 CDD:293786
ANK repeat 2560..2587 CDD:293786
ANK repeat 2591..2622 CDD:293786
KH-I_MASK 3047..3116 CDD:411832
Blue background indicates that the domain is not in the aligned region.

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