Protein Alignment PLA2G6 and pla2g6

DIOPT Version :10

• Sequence 1: NP_003551.2
• Gene: PLA2G6 / 8398
• HGNCID: 9039
• Length: 806
• Species: Homo sapiens
• Sequence 2: XP_073792472.1
• Gene: pla2g6 / 406370
• ZFINID: ZDB-GENE-040426-2079
• Length: 824
• Species: Danio rerio
• Alignment Length: 832
• Identity: 439/832 - (52%)
• Similarity: 576/832 - (69%)
• Gaps: 44/832 - (5%)

Human     1 MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNS 65
            |||.||:::|.|.|::|||||:||::|.::||......::||:|.|::|..:::|||:|:.|.:.
Zfish     7 MQFLGRILDTVSSVSSLFSNPYRVRDVQLSDYNGKILHQQEGRLALYRNQQSQSWDCLLLCPESP 71

Human    66 QSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELG 130
            ....|:||:..|.||:..|.||:.:|.||||.....|..|:||.:.|.:||||.||.||:||:.|
Zfish    72 SVALRMFQVASEEDAMNWFPQYALKLRPFYEMLRPPLKPEMLQPIVDCVRNHPDWSSAHIAVDTG 136

Human   131 IRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQ 195
            :|:|..|:.|:|..| :.:.:|.|||||||.:||...:.||::.|..:.||.|..|||..|.|.:
Zfish   137 LRDCLKHNYILSQMN-SRDAQGQTPLHLACERGDVGCVRELLEECQARTDVKDKNGETPMHCAAK 200

Human   196 GDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAM 260
            .|::.::::|.....||:|::|..|.||:|:||:||:.|:|:.||...|||:|||.||:|||:||
Zfish   201 QDSALIIEVLCAQLCAGVNELNAAGETPMHIACRLGRVEVVKGLLGGGARCDIMGNNGFPIHTAM 265

Human   261 KFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAV 325
            |||:|.|||.|:|...:|:.::||.||.:||||||.|||:|:||.||||||..|..|.:.||:..
Zfish   266 KFSEKSCAEAILSSSPNQLLAEDPVYGGTPLHWAKTAEMSRLLLDRGCNVNYLSKTGESPLHILT 330

Human   326 MRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLA 390
            .|.||:.|:.||||||:|:.||:.|||.|||||..||:::||||:||||:|:..||.||||..:|
Zfish   331 KRGRFEAAMTLLTHGADANIRGQDGNTALHLAMKLDNMDLIKALMVFGADVEVHNDVGETPGLIA 395

Human   391 SKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLM 455
            ::..:...||.:|.:|.:||.|.|.||        ...:|.|  ||.:|.||.|..:     |:|
Zfish   396 ARTSKGSNRKVLLNMLCSVGVERCHPP--------SLNSPTH--SLRKAPPPGIGFD-----DIM 445

Human   456 HIS---RARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAG 517
            .::   .|....|:...........|.||||||||:|||::||||||:||.:|...::|||||:|
Zfish   446 QVAVAVTAMSRGFVEADGLKTGNKMDRLLCLDGGGIKGLVLIQLLIALEKEAGRPIRELFDWVSG 510

Human   518 TSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKV 582
            |||||||||||:|.|||.|:|.:|||||::||:|||||||||||||||.||||:||||||..|:|
Zfish   511 TSTGGILALAIVHGKSMEYLRCLYFRMKEQVFKGSRPYESGPLEEFLKNEFGENTKMTDVTHPRV 575

Human   583 MLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQP---------------------- 625
            |:|..|:||.|.|||||||||.|...|:|.:......:|...|
Zfish   576 MVTSVLADRHPGELHLFRNYDPPALQRDPPYKSTATFQPLTVPQGWEDEDLLLVGYTRPPRKRRK 640

Human   626 ---SDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKL 687
               .:|||||||||||||||||||.||||||||||||||||||||||::|:.|..:|:...|.:|
Zfish   641 VTDEEQLVWRAARSSGAAPTYFRPMGRFLDGGLLANNPTLDAMTEIHQFNKALKAQGRDEDVTRL 705

Human   688 SIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEM 752
            .:|||||||:.|||.|..|||||||||.|||||..|.||||||:||||||.||.|||||||||||
Zfish   706 GVVVSLGTGKPPQVAVNSVDVFRPSNPIELAKTFVGVKELGKMLVDCCTDSDGCAVDRARAWCEM 770

Human   753 VGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLL 804
            ..|.|.||:|||..::|||||||.|||:.||||::|:||||:..|.|.|.||
Zfish   771 ADINYHRLSPQLSQEVMLDEVSDAVLVDMLWETQMYLYEHRDVIQTLCQQLL 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLA2G6	NP_003551.2	ANKYR	105..407	CDD:440430	151/301 (50%)
		ANK repeat	118..149	CDD:293786	14/30 (47%)
		ANK 1. /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8	120..147		13/26 (50%)
		ANK repeat	151..183	CDD:293786	15/31 (48%)
		ANK 1. /evidence=ECO:0000255	151..181		13/29 (45%)
		ANK repeat	185..217	CDD:293786	10/31 (32%)
		ANK 2. /evidence=ECO:0000255	185..215		9/29 (31%)
		ANK repeat	219..248	CDD:293786	15/28 (54%)
		ANK 3. /evidence=ECO:0000255	219..248		15/28 (54%)
		ANK 4. /evidence=ECO:0000255	251..281		17/29 (59%)
		ANK repeat	286..314	CDD:293786	20/27 (74%)
		ANK 5. /evidence=ECO:0000255	286..312		19/25 (76%)
		ANK repeat	316..347	CDD:293786	14/30 (47%)
		ANK 6. /evidence=ECO:0000255	316..345		14/28 (50%)
		ANK repeat	349..380	CDD:293786	19/30 (63%)
		ANK 7. /evidence=ECO:0000255	349..378		19/28 (68%)
		ANK 9. /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8	382..403		7/20 (35%)
		Pat_PNPLA9	480..793	CDD:132851	218/337 (65%)
		GXGXXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	485..490		3/4 (75%)
		GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	517..521		3/3 (100%)
		DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	652..654		1/1 (100%)
		Calmodulin-binding (1-9-14 motif). /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8	677..686		2/8 (25%)
		Calmodulin-binding (IQ motif). /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8	748..759		7/10 (70%)
pla2g6	XP_073792472.1	None