DRSC/TRiP Functional Genomics Resources

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Protein Alignment PLA2G6 and Arms

DIOPT Version :10

Sequence 1:NP_003551.2 Gene:PLA2G6 / 8398 HGNCID:9039 Length:806 Species:Homo sapiens
Sequence 2:NP_726059.5 Gene:Arms / 37433 FlyBaseID:FBgn0261554 Length:1642 Species:Drosophila melanogaster


Alignment Length:733 Identity:154/733 - (21%)
Similarity:259/733 - (35%) Gaps:208/733 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    55 WDCVLVNPRNSQSGFRLFQLELEADALVNFHQ---YSSQLLPFYESSPQVLHTEVLQ-------- 108
            |..:|...||..  ..:.||.|:..|.|....   ::|.:...|..     |||:::        
  Fly   237 WTALLCASRNGH--LDVVQLLLDHGAEVEHRDMGGWTSLMWAAYRG-----HTELVRLLLDKGAD 294

Human   109 -------HLTDLIRNHPSWS-------VAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLA 159
                   ||..|:     |:       :..|.|:.|.:           .|..: :.|.|.|..|
  Fly   295 GNAHGNYHLGALL-----WAAGRGYKDIVELLVQRGAK-----------VNVGD-KYGTTALVWA 342

Human   160 CRKGDGEILVELVQYCHTQMDVTD-YKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTP 223
            ||:|:.||:..|:: ....:|... |....:...|..|....|..:|.:.  ..:|.::..|:|.
  Fly   343 CRRGNVEIVDTLLK-AGANVDTAGMYSWTPLLVAAAGGHTDCVSSILEKK--PNVNALDKDGMTA 404

Human   224 LHLACQLGKQEMVRVLLLCNARCNIMGPNG-YPIHSAMKFSQKGCAEMIISMDSS-QIHSKDPRY 286
            |.:|.:.|.|::...|:...|..||..... .|:..|:|...:...|.::...:. .|..||.:.
  Fly   405 LCIASREGFQDIAASLIAAGAYINIQDRGADTPLIHAVKAGHRTVVEALLKKHADVDIQGKDRKT 469

Human   287 GASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGN 351
            .........:..:.::||....::.|.:..|:|.|..||.....:...:||...|...|..:.|:
  Fly   470 AIYTAVEKGHTPIVKLLLATNPDLESATKDGDTPLLRAVRNRNLEIVHLLLDRKAKVTASDKRGD 534

Human   352 TPLHLAMSKDNVEMIKAL--------IVFGAEVDTPNDFGETP---------TFLASKIG--RLV 397
            |.||:||...:..:::||        :::.|     |..||||         |.|....|  ||.
  Fly   535 TCLHIAMRARSKTIVEALLRNPKHSQLLYRA-----NKAGETPYNIDSLHQKTILGQVFGARRLN 594

Human   398 TRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARK 462
            |.:....:|   |.|.....:..|.:|.             ....||::.       ::......
  Fly   595 TNEDSEGML---GYELYSSALADVLSEP-------------TLTTPITVG-------LYAKWGSG 636

Human   463 PAFILGSMRDEK------------RTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDW- 514
            .:|:|..:|||.            ||         .|:..::.:.:.:.|....|::|     | 
  Fly   637 KSFLLNKLRDEMNNFARQWAEPPIRT---------SGLLFIVCLHVALLIGTIVGLST-----WS 687

Human   515 -VAGTSTG-GILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDV 577
             |.|.|.. |.|.||.|   .:|.:|...::|              .::.....:.|...:||.:
  Fly   688 AVVGVSAAVGFLLLAYL---LLAAVRYCNYQM--------------DMQWAYSVQHGLEKRMTRL 735

Human   578 RKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQ----LVWRAARSSG 638
            |   ::|       |.|..|                       ||...||.    :.:..|.::.
  Fly   736 R---LIL-------QVAFCH-----------------------PPGPQSDSQAKPVRFHFAEANS 767

Human   639 AAPTYFRPNGRFLDGG---LLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQ 700
            |:||.        ||.   :||  ..|||: |.| |.....|..:|.:.|.|.:.|.....|...
  Fly   768 ASPTG--------DGAVAHMLA--ALLDAI-ESH-YGWLATRLYRAFRPKCLKVDVGWRWRRMCC 820

Human   701 VPVTCVDVFRPSNPWELA 718
            :|:..:        :|||
  Fly   821 IPIVLI--------FELA 830

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLA2G6NP_003551.2 ANKYR 105..407 CDD:440430 75/345 (22%)
ANK repeat 118..149 CDD:293786 5/37 (14%)
ANK 1. /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8 120..147 5/33 (15%)
ANK repeat 151..183 CDD:293786 11/31 (35%)
ANK 1. /evidence=ECO:0000255 151..181 10/29 (34%)
ANK repeat 185..217 CDD:293786 5/31 (16%)
ANK 2. /evidence=ECO:0000255 185..215 4/29 (14%)
ANK repeat 219..248 CDD:293786 8/28 (29%)
ANK 3. /evidence=ECO:0000255 219..248 8/28 (29%)
ANK 4. /evidence=ECO:0000255 251..281 5/31 (16%)
ANK repeat 286..314 CDD:293786 3/27 (11%)
ANK 5. /evidence=ECO:0000255 286..312 2/25 (8%)
ANK repeat 316..347 CDD:293786 9/30 (30%)
ANK 6. /evidence=ECO:0000255 316..345 8/28 (29%)
ANK repeat 349..380 CDD:293786 9/38 (24%)
ANK 7. /evidence=ECO:0000255 349..378 9/36 (25%)
ANK 9. /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8 382..403 10/31 (32%)
Pat_PNPLA9 480..793 CDD:132851 52/249 (21%)
GXGXXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161 485..490 1/4 (25%)
GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161 517..521 2/3 (67%)
DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161 652..654 1/1 (100%)
Calmodulin-binding (1-9-14 motif). /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8 677..686 2/8 (25%)
Calmodulin-binding (IQ motif). /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8 748..759
ArmsNP_726059.5 ANKYR 172..438 CDD:440430 49/227 (22%)
ANK repeat 205..233 CDD:293786
ANK repeat 235..266 CDD:293786 9/30 (30%)
ANK repeat 268..299 CDD:293786 5/35 (14%)
ANK repeat 301..332 CDD:293786 8/46 (17%)
ANKYR 316..598 CDD:440430 70/301 (23%)
ANK repeat 334..362 CDD:293786 10/28 (36%)
ANK repeat 367..398 CDD:293786 6/32 (19%)
ANK repeat 400..431 CDD:293786 10/30 (33%)
ANK repeat 435..464 CDD:293786 5/28 (18%)
ANK repeat 466..497 CDD:293786 4/30 (13%)
ANK repeat 499..530 CDD:293786 9/30 (30%)
KAP_NTPase 605..1136 CDD:462231 64/330 (19%)
SAM_superfamily 1357..1392 CDD:188886
Blue background indicates that the domain is not in the aligned region.

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