Protein Alignment PLA2G6 and Pla2g6

DIOPT Version :10

• Sequence 1: NP_003551.2
• Gene: PLA2G6 / 8398
• HGNCID: 9039
• Length: 806
• Species: Homo sapiens
• Sequence 2: XP_006242059.1
• Gene: Pla2g6 / 360426
• RGDID: 628867
• Length: 868
• Species: Rattus norvegicus
• Alignment Length: 831
• Identity: 723/831 - (87%)
• Similarity: 760/831 - (91%)
• Gaps: 25/831 - (3%)

Human     1 MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNS 65
            ||||||||||.|.||||||||||||||::|||.||:||||||||||.||..|||||||||:|||.
  Rat    38 MQFFGRLVNTLSSVTNLFSNPFRVKEVSLADYASSERVREEGQLILLQNASNRTWDCVLVSPRNP 102

Human    66 QSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELG 130
            ||||||||||.||||||||.||||||.||||||.||||.||||||||||||||||:|.|||||||
  Rat   103 QSGFRLFQLESEADALVNFQQYSSQLPPFYESSVQVLHVEVLQHLTDLIRNHPSWTVTHLAVELG 167

Human   131 IRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQ 195
            |||||||||||||||..|||||||||||||||||.|||||||||||.||||||.||||.||||||
  Rat   168 IRECFHHSRIISCANSTENEEGCTPLHLACRKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQ 232

Human   196 GDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAM 260
            |||.|||||||:||.|||||||||||||||||||:|||||||||||||||||||||.|:|||:||
  Rat   233 GDNPQVLQLLGKNASAGLNQVNNQGLTPLHLACQMGKQEMVRVLLLCNARCNIMGPGGFPIHTAM 297

Human   261 KFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAV 325
            ||||||||||||||||:|||||||||||||||||||||||||||||||:|:|||::|||||||||
  Rat   298 KFSQKGCAEMIISMDSNQIHSKDPRYGASPLHWAKNAEMARMLLKRGCDVDSTSASGNTALHVAV 362

Human   326 MRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLA 390
            .||||||.:||||:||||.||||||||||||||||||:||:||||||||||||||||||||.|:|
  Rat   363 TRNRFDCVMVLLTYGANAGARGEHGNTPLHLAMSKDNMEMVKALIVFGAEVDTPNDFGETPAFIA 427

Human   391 SKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHP-FSLERAQPPPISLNNLELQDL 454
            |||.:|:||||:||||:||||:|.||.|.||..||.|||..|| |||:|.|||.|||||||||||
  Rat   428 SKISKLITRKALLTLLKTVGADYHFPFIQGVSTEQSSAAGPHPFFSLDRTQPPTISLNNLELQDL 492

Human   455 MHISRARKPAFILGSMRDEKR------------------------THDHLLCLDGGGVKGLIIIQ 495
            |.:||||||||||.|||||||                        :|||||||||||||||:|||
  Rat   493 MPVSRARKPAFILSSMRDEKRRLLSTLGSLLLEAFLGGTTDFQSESHDHLLCLDGGGVKGLVIIQ 557

Human   496 LLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPL 560
            ||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||
  Rat   558 LLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPL 622

Human   561 EEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQP 625
            |||||||||||||||||:||||||||||||||||||||||||||||.|||||...|:||:||.||
  Rat   623 EEFLKREFGEHTKMTDVKKPKVMLTGTLSDRQPAELHLFRNYDAPEAVREPRCTPNINLKPPTQP 687

Human   626 SDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIV 690
            :||||||||||||||||||||||||||||||||||||||||||||||||:|||||.|||||||||
  Rat   688 ADQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDMIRKGQGNKVKKLSIV 752

Human   691 VSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGI 755
            ||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   753 VSLGTGKSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGI 817

Human   756 QYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP 806
            ||||||||||:|||||||||.|||||||||||||||||||||||:||||||
  Rat   818 QYFRLNPQLGSDIMLDEVSDAVLVNALWETEVYIYEHREEFQKLVQLLLSP 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLA2G6	NP_003551.2	ANKYR	105..407	CDD:440430	268/301 (89%)
		ANK repeat	118..149	CDD:293786	26/30 (87%)
		ANK 1. /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8	120..147		24/26 (92%)
		ANK repeat	151..183	CDD:293786	29/31 (94%)
		ANK 1. /evidence=ECO:0000255	151..181		27/29 (93%)
		ANK repeat	185..217	CDD:293786	27/31 (87%)
		ANK 2. /evidence=ECO:0000255	185..215		25/29 (86%)
		ANK repeat	219..248	CDD:293786	27/28 (96%)
		ANK 3. /evidence=ECO:0000255	219..248		27/28 (96%)
		ANK 4. /evidence=ECO:0000255	251..281		25/29 (86%)
		ANK repeat	286..314	CDD:293786	25/27 (93%)
		ANK 5. /evidence=ECO:0000255	286..312		24/25 (96%)
		ANK repeat	316..347	CDD:293786	24/30 (80%)
		ANK 6. /evidence=ECO:0000255	316..345		23/28 (82%)
		ANK repeat	349..380	CDD:293786	28/30 (93%)
		ANK 7. /evidence=ECO:0000255	349..378		26/28 (93%)
		ANK 9. /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8	382..403		15/20 (75%)
		Pat_PNPLA9	480..793	CDD:132851	296/312 (95%)
		GXGXXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	485..490		4/4 (100%)
		GXSXG. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	517..521		3/3 (100%)
		DGA/G. /evidence=ECO:0000255|PROSITE-ProRule:PRU01161	652..654		1/1 (100%)
		Calmodulin-binding (1-9-14 motif). /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8	677..686		7/8 (88%)
		Calmodulin-binding (IQ motif). /evidence=ECO:0000250|UniProtKB:A0A3L7I2I8	748..759		10/10 (100%)
Pla2g6	XP_006242059.1	ANKYR	139..444	CDD:440430	270/304 (89%)
		ANK repeat	156..186	CDD:293786	25/29 (86%)
		ANK repeat	188..220	CDD:293786	29/31 (94%)
		ANK repeat	222..254	CDD:293786	27/31 (87%)
		ANK repeat	256..285	CDD:293786	27/28 (96%)
		ANK repeat	323..351	CDD:293786	25/27 (93%)
		ANK repeat	353..384	CDD:293786	24/30 (80%)
		ANK repeat	386..417	CDD:293786	28/30 (93%)
		Pat_PNPLA9	542..855	CDD:132851	296/312 (95%)