Protein Alignment HDAC10 and HDAC1

DIOPT Version :10

• Sequence 1: NP_114408.3
• Gene: HDAC10 / 83933
• HGNCID: 18128
• Length: 669
• Species: Homo sapiens
• Sequence 2: NP_647918.2
• Gene: HDAC1 / 38565
• FlyBaseID: FBgn0015805
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 319
• Identity: 82/319 - (25%)
• Similarity: 138/319 - (43%)
• Gaps: 58/319 - (18%)

Human    27 RPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEE----LQALS 87
            :|.|:....:.|...||.::.......:|:.:|:...||.|||..:|..:.....|    :|..:
  Fly    29 KPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYVRFLRSIRPDNMSEYNKQMQRFN 93

Human    88 -GQ----FDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG----------HHGQ 137
             |:    ||.:|      ...:|:||           |:|...:.|.:...          ||.:
  Fly    94 VGEDCPVFDGLY------EFCQLSAG-----------GSVAAAVKLNKQASEICINWGGGLHHAK 141

Human   138 RAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRF 202
            ::.|:|||..|::.:......:.|  .|:|.:|.|||||.|::..|.....|:..|:|:|  |.:
  Fly   142 KSEASGFCYVNDIVLGILELLKYH--QRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKY--GEY 202

Human   203 WPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSA 267
            :|  ...|...:|.|:|..:.||:|... ||.:..|.:.|:.::..:...|.|..|::..|.||.
  Fly   203 FP--GTGDLRDIGAGKGKYYAVNIPLRD-GMDDDAYESIFVPIISKVMETFQPAAVVLQCGADSL 264

Human   268 IGDPEGQMQAT----PEC--FAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQT 320
            .||..|....|    .:|  |.....|..::.||       |||.:.::  |.|.|.:|
  Fly   265 TGDRLGCFNLTVKGHGKCVEFVKKYNLPFLMVGG-------GGYTIRNV--SRCWTYET 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC10	NP_114408.3	Histone deacetylase	1..323		82/319 (26%)
		HDAC10	18..354	CDD:212546	82/319 (26%)
		Substrate specificity. /evidence=ECO:0000250|UniProtKB:F1QCV2	21..24
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	361..387
		Arginase_HDAC	<562..634	CDD:450134
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:450134	82/319 (26%)